Bernd Neumaier
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View article: Radiochemical methods in production of radionuclides at a cyclotron
Radiochemical methods in production of radionuclides at a cyclotron Open
Extensive use of radiochemical methods has been made over decades in radionuclide development work at different cyclotrons at the Forschungszentrum Jülich. In this article, a brief overview of the methods used in investigations on nuclear …
View article: [18F]R91150: A promising candidate for 5-HT2A-PET imaging
[18F]R91150: A promising candidate for 5-HT2A-PET imaging Open
View article: Fully Automated Cassette-Based Synthesis of [18F]T807 on a Trasis AllinOne module
Fully Automated Cassette-Based Synthesis of [18F]T807 on a Trasis AllinOne module Open
View article: 73/75Se-Labeling by preparation of Se-N-bonded 1,2,5-selendiazoles
73/75Se-Labeling by preparation of Se-N-bonded 1,2,5-selendiazoles Open
View article: Preparation of Aliphatic Sulfamoyl [18F]Fluorides ([18F]ASAFs) Using the "Minimalist Green" Approach
Preparation of Aliphatic Sulfamoyl [18F]Fluorides ([18F]ASAFs) Using the "Minimalist Green" Approach Open
View article: Radiosynthesis and stability evaluation of [18F]sulfonimidoyl fluorides
Radiosynthesis and stability evaluation of [18F]sulfonimidoyl fluorides Open
View article: Preliminary First-in-Human Pharmacokinetic Evaluation, Dosimetry and Safety of 7-[<sup>18</sup>F]-Fluorotryptophan as PET Imaging Agent to Visualize Serotonin Synthesis in the Brain
Preliminary First-in-Human Pharmacokinetic Evaluation, Dosimetry and Safety of 7-[<sup>18</sup>F]-Fluorotryptophan as PET Imaging Agent to Visualize Serotonin Synthesis in the Brain Open
Tryptophan (Trp) is the precursor for serotonin synthesis and other biologically relevant metabolites. We evaluated the novel radiotracer 7-[ 18 F]Fluorotryptophan (7-[ 18 F]FTrp) to assess its biodistribution, dosimetry, and potential for…
View article: Cross-section measurements of the 93Nb(p,n)93mMo reaction up to 17 MeV
Cross-section measurements of the 93Nb(p,n)93mMo reaction up to 17 MeV Open
The nuclear reaction cross-sections of the 93 Nb(p,n) 93m Mo process were measured in three experiments up to 17 MeV proton energy by using the stacked target foil technique. The target stacks were irradiated at the cyclotron JSW BC 1710 a…
View article: An overview of production routes of the non-standard positron emitter <sup>86g</sup>Y with emphasis on a comparative analysis of the <sup>86</sup>Sr(p,n)- and <sup>86</sup>Sr(d,2n)-reactions
An overview of production routes of the non-standard positron emitter <sup>86g</sup>Y with emphasis on a comparative analysis of the <sup>86</sup>Sr(p,n)- and <sup>86</sup>Sr(d,2n)-reactions Open
A very brief overview of the hitherto investigated production routes of 86g Y is given, and a comparative analysis of its production via the two low-energy reactions, namely (p,n) and (d,2n) on 96.4 % enriched 86 Sr as target material, is …
View article: Fully Automated Production of (((S)-1-Carboxy-5-(6-([18F]fluoro)-2-methoxynicotinamido)pentyl)carbamoyl)-l-glutamic Acid ([18F]JK-PSMA-7)
Fully Automated Production of (((S)-1-Carboxy-5-(6-([18F]fluoro)-2-methoxynicotinamido)pentyl)carbamoyl)-l-glutamic Acid ([18F]JK-PSMA-7) Open
Background: The radiotracer [18F]JK-PSMA-7, a prostate cancer imaging agent for positron emission tomography (PET), was previously synthesized by indirect radiofluorination using an 18F-labeled active ester as a prosthetic group, which had…
View article: Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity
Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity Open
View article: Do you know your PSMA-tracer? Variability in the biodistribution of different PSMA ligands and its potential impact on defining PSMA-positivity prior to PSMA-targeted therapy
Do you know your PSMA-tracer? Variability in the biodistribution of different PSMA ligands and its potential impact on defining PSMA-positivity prior to PSMA-targeted therapy Open
View article: [18F]R91150: Improved radiosynthesis and in vivo evaluation as imaging probe for 5-HT2A receptors
[18F]R91150: Improved radiosynthesis and in vivo evaluation as imaging probe for 5-HT2A receptors Open
Serotonergic 5-HT2A receptors in the cortex and other forebrain structures have been linked to cognitive, emotional and memory processes. In addition, dysfunction or altered expression of these receptors is associated with neuro…
View article: Preparation and Preclinical Evaluation of 18F-Labeled Olutasidenib Derivatives for Non-Invasive Detection of Mutated Isocitrate Dehydrogenase 1 (mIDH1)
Preparation and Preclinical Evaluation of 18F-Labeled Olutasidenib Derivatives for Non-Invasive Detection of Mutated Isocitrate Dehydrogenase 1 (mIDH1) Open
Mutations of isocitrate dehydrogenase 1 (IDH1) are key biomarkers for glioma classification, but current methods for detection of mutated IDH1 (mIDH1) require invasive tissue sampling and cannot be used for longitudinal studies. Positron e…
View article: Cerebellar Metabolic Connectivity during Treadmill Walking before and after Unilateral Dopamine Depletion in Rats
Cerebellar Metabolic Connectivity during Treadmill Walking before and after Unilateral Dopamine Depletion in Rats Open
Compensatory changes in brain connectivity keep motor symptoms mild in prodromal Parkinson’s disease. Studying compensation in patients is hampered by the steady progression of the disease and a lack of individual baseline controls. Furthe…
View article: Excitation functions of 72Ge(p,xn)72,71As reactions from threshold up to 45 MeV for production of the non-standard positron emitter 72As
Excitation functions of 72Ge(p,xn)72,71As reactions from threshold up to 45 MeV for production of the non-standard positron emitter 72As Open
View article: Excitation functions and isomeric cross-section ratios of (d,xn) reactions on $$^{86}$$Sr
Excitation functions and isomeric cross-section ratios of (d,xn) reactions on $$^{86}$$Sr Open
View article: Repeated caffeine intake suppresses cerebral grey matter responses to chronic sleep restriction in an A1 adenosine receptor-dependent manner: a double-blind randomized controlled study with PET-MRI
Repeated caffeine intake suppresses cerebral grey matter responses to chronic sleep restriction in an A1 adenosine receptor-dependent manner: a double-blind randomized controlled study with PET-MRI Open
Evidence has shown that both sleep loss and daily caffeine intake can induce changes in grey matter (GM). Caffeine is frequently used to combat sleepiness and impaired performance caused by insufficient sleep. It is unclear (1) whether dai…
View article: Radiosynthesis and Preclinical Evaluation of <i>m</i>-[<sup>18</sup>F]FET and [<sup>18</sup>F]FET-OMe as Novel [<sup>18</sup>F]FET Analogs for Brain Tumor Imaging
Radiosynthesis and Preclinical Evaluation of <i>m</i>-[<sup>18</sup>F]FET and [<sup>18</sup>F]FET-OMe as Novel [<sup>18</sup>F]FET Analogs for Brain Tumor Imaging Open
O-([18F]Fluoroethyl)-l-tyrosine ([18F]FET) is actively transported into the brain and cancer cells by LAT1 and possibly other amino acid transporters, which enables brain tumor imaging by positron emission tomo…
View article: 8-Bicycloalkyl-CPFPX derivatives as potent and selective tools for in vivo imaging of the A1 adenosine receptor
8-Bicycloalkyl-CPFPX derivatives as potent and selective tools for in vivo imaging of the A1 adenosine receptor Open
Imaging of the A1 adenosine receptor (A1R) by positron emission tomography (PET) with 8-cyclopentyl-3-(3-[18F]fluoropropyl)-1-propyl-xanthine ([18F]CPFPX) has been widely used in preclinical and …
View article: Improved Tau PET SUVR Quantification in 4-Repeat Tau Phenotypes with [<sup>18</sup>F]PI-2620
Improved Tau PET SUVR Quantification in 4-Repeat Tau Phenotypes with [<sup>18</sup>F]PI-2620 Open
We used a new data-driven methodology to identify a set of reference regions that enhanced the quantification of the SUV ratio of the second-generation tau tracer 2-(2-([18F]fluoro)pyridin-4-yl)-9H-pyrrolo[2,3-b:4,5-c']dipyridin…
View article: Preserved striatal innervation maintains motor function despite severe loss of nigral dopaminergic neurons
Preserved striatal innervation maintains motor function despite severe loss of nigral dopaminergic neurons Open
Degeneration of dopaminergic neurons in the substantia nigra and their striatal axon terminals causes cardinal motor symptoms of Parkinson’s disease. In idiopathic cases, high levels of mitochondrial DNA alterations, leading to mitochondri…
View article: Radiosynthesis and In Vitro Evaluation of [11C]tozadenant as Adenosine A2A Receptor Radioligand
Radiosynthesis and In Vitro Evaluation of [11C]tozadenant as Adenosine A2A Receptor Radioligand Open
Tozadenant (4-hydroxy-N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-4-methylpiperidine-1-carboxamide) is a highly selective adenosine A2A receptor (A2AR) antagonist and a promising lead structure for the development of A2AR-selective posi…
View article: Desmethyl SuFEx-IT: SO<sub>2</sub>F<sub>2</sub>-Free Synthesis and Evaluation as a Fluorosulfurylating Agent
Desmethyl SuFEx-IT: SO<sub>2</sub>F<sub>2</sub>-Free Synthesis and Evaluation as a Fluorosulfurylating Agent Open
Access to SuFExable compounds was remarkably simplified by introduction of the solid FO2S-donor SuFEx-IT. However, the published process for preparation of this reagent relies on the use of sulfuryl fluoride (SO2F
View article: Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity
Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity Open
Dysfunctions in autophagy, a cellular mechanism for breaking down components within lysosomes, often lead to neurodegeneration. The specific mechanisms underlying neuronal vulnerability to autophagy dysfunction remain elusive. Here, we sho…
View article: Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity
Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity Open
Dysfunctions in autophagy, a highly conserved cellular mechanism responsible for the degradation of intracellular components within lysosomes, often result in neurodegeneration. The neuroprotective effect of autophagy varies across neurona…
View article: Radiochemical isolation of 45Ti using ion chromatography
Radiochemical isolation of 45Ti using ion chromatography Open
45 Ti exhibits favorable decay properties for positron emission tomography (PET) imaging and can be easily produced by the bombardment of natural scandium (Sc) by protons using the 45 Sc(p,n) 45 Ti nuclear reaction. However, separation of …
View article: A Volume‐Based Alternative for classifying ATN: Data from the Tau Propagation over Time (T‐POT) cohort
A Volume‐Based Alternative for classifying ATN: Data from the Tau Propagation over Time (T‐POT) cohort Open
Background Alzheimer’s disease (AD) is characterized by the cerebral accumulation of amyloid‐beta (A), tau (T), and progressive neurodegeneration (N). The widely used ATN system, with regard to positron emission tomography (PET) biomarkers…
View article: Editorial: Prof. Frank Rösch's legacy in the radiopharmaceutical chemistry field
Editorial: Prof. Frank Rösch's legacy in the radiopharmaceutical chemistry field Open
EDITORIAL article Front. Nucl. Med., 27 November 2023Sec. Radiopharmacy and Radiochemistry Volume 3 - 2023 | https://doi.org/10.3389/fnume.2023.1336481
View article: In Vivo Measurement of Tau Depositions in Anti-IgLON5 Disease Using [18F]PI-2620 PET
In Vivo Measurement of Tau Depositions in Anti-IgLON5 Disease Using [18F]PI-2620 PET Open
The results indicate that tau depositions in anti-IgLON5 disease can be visualized with [18F]PI-2620 and might correlate with the extent of disease. For validation, a larger longitudinal study is necessary.