Jörg Schwender
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View article: Resolving cofactor imbalance in triacylglycerol biosynthesis in oilseeds through glycolytic shunts: a modeling study
Resolving cofactor imbalance in triacylglycerol biosynthesis in oilseeds through glycolytic shunts: a modeling study Open
During seed development, carbohydrates are rapidly converted into triacylglycerols (TAGs), with glycolysis and the oxidative pentose phosphate pathway (OPPP) traditionally considered key sources of acetyl-CoA, ATP, NADH, and NADPH for fatt…
View article: The target of rapamycin kinase is a positive regulator of plant fatty acid and lipid synthesis
The target of rapamycin kinase is a positive regulator of plant fatty acid and lipid synthesis Open
In eukaryotes, target of rapamycin (TOR), a conserved protein sensor kinase, integrates diverse environmental cues, including growth factor signals, energy availability, and nutritional status, to direct cell growth. In plants, TOR is acti…
View article: Development of vegetative oil sorghum: From lab‐to‐field
Development of vegetative oil sorghum: From lab‐to‐field Open
Summary Biomass crops engineered to accumulate energy‐dense triacylglycerols (TAG or ‘vegetable oils’) in their vegetative tissues have emerged as potential feedstocks to meet the growing demand for renewable diesel and sustainable aviatio…
View article: Mechanical forces orchestrate the metabolism of the developing oilseed rape embryo
Mechanical forces orchestrate the metabolism of the developing oilseed rape embryo Open
Summary The initial free expansion of the embryo within a seed is at some point inhibited by its contact with the testa, resulting in its formation of folds and borders. Although less obvious, mechanical forces appear to trigger and accele…
View article: Creating yellow seed <i>Camelina sativa</i> with enhanced oil accumulation by <scp>CRISPR</scp>‐mediated disruption of <i>Transparent Testa 8</i>
Creating yellow seed <i>Camelina sativa</i> with enhanced oil accumulation by <span>CRISPR</span>‐mediated disruption of <i>Transparent Testa 8</i> Open
Summary Camelina ( Camelina sativa L.), a hexaploid member of the Brassicaceae family, is an emerging oilseed crop being developed to meet the increasing demand for plant oils as biofuel feedstocks. In other Brassicas, high oil content can…
View article: Commentary: Duckweeds as model organisms for metabolic studies
Commentary: Duckweeds as model organisms for metabolic studies Open
Duckweeds have many practical applications, for example in human nutrition, as animal feed, in the production of bioplastics or vaccines, and phytoremediation (Acosta et al., 2021). Under most conditions, they reproduce asexually which pro…
View article: Mechanisms of metabolic adaptation in the duckweed Lemna gibba: an integrated metabolic, transcriptomic and flux analysis
Mechanisms of metabolic adaptation in the duckweed Lemna gibba: an integrated metabolic, transcriptomic and flux analysis Open
Background Duckweeds are small, rapidly growing aquatic flowering plants. Due to their ability for biomass production at high rates they represent promising candidates for biofuel feedstocks. Duckweeds are also excellent model organisms be…
View article: Walking the ‘design–build–test–learn’ cycle: flux analysis and genetic engineering reveal the pliability of plant central metabolism
Walking the ‘design–build–test–learn’ cycle: flux analysis and genetic engineering reveal the pliability of plant central metabolism Open
This article is a Commentary on Morley et al . (2023), 239 : 1834–1851.
View article: Accelerating the development of a sustainable bioenergy portfolio through stable isotopes
Accelerating the development of a sustainable bioenergy portfolio through stable isotopes Open
Bioenergy could help limit global warming to 2°C above pre‐industrial levels while supplying almost a fourth of the world's renewable energy needs by 2050. However, the deployment of bioenergy raises concerns that adoption at meaningful sc…
View article: <scp>CYCLIN‐DEPENDENT KINASE</scp> 8 positively regulates oil synthesis by activating <scp>WRINKLED1</scp> transcription
<span>CYCLIN‐DEPENDENT KINASE</span> 8 positively regulates oil synthesis by activating <span>WRINKLED1</span> transcription Open
Summary CYCLIN‐DEPENDENT KINASE 8 (CDK8), a component of the kinase module of the Mediator complex in Arabidopsis, is involved in many processes, including flowering, plant defense, drought, and energy stress responses. Here, we investigat…
View article: Additional file 1 of Mechanisms of metabolic adaptation in the duckweed Lemna gibba: an integrated metabolic, transcriptomic and flux analysis
Additional file 1 of Mechanisms of metabolic adaptation in the duckweed Lemna gibba: an integrated metabolic, transcriptomic and flux analysis Open
Additional file 1: Table S1. Increase in fronds area (cm2) during culture time (hours). Means and standard deviations represented three independent replicates. Table S2. Metabolite analysis by Liquid Chromatography / Mass Spectrometry. See…
View article: Engineering triacylglycerol accumulation in duckweed (<i>Lemna japonica</i>)
Engineering triacylglycerol accumulation in duckweed (<i>Lemna japonica</i>) Open
Summary Duckweeds are amongst the fastest growing of higher plants, making them attractive high‐biomass targets for biofuel feedstock production. Their fronds have high rates of fatty acid synthesis to meet the demand for new membranes, bu…
View article: An expanded role for the transcription factor WRINKLED1 in the biosynthesis of triacylglycerols during seed development
An expanded role for the transcription factor WRINKLED1 in the biosynthesis of triacylglycerols during seed development Open
The transcription factor WRINKLED1 ( WRI1 ) is known as a master regulator of fatty acid synthesis in developing oilseeds of Arabidopsis thaliana and other species. WRI1 is known to directly stimulate the expression of many fatty acid bios…
View article: Purple acid phosphatase2 stimulates a futile cycle of lipid synthesis and degradation, and mitigates the negative growth effects of triacylglycerol accumulation in vegetative tissues
Purple acid phosphatase2 stimulates a futile cycle of lipid synthesis and degradation, and mitigates the negative growth effects of triacylglycerol accumulation in vegetative tissues Open
Summary Storage lipids (mostly triacylglycerols, TAGs) serve as an important energy and carbon reserve in plants, and hyperaccumulation of TAG in vegetative tissues can have negative effects on plant growth. Purple acid phosphatase2 (PAP2)…
View article: Elucidation of Triacylglycerol Overproduction in the C4 Bioenergy Crop Sorghum bicolor by Constraint-Based Analysis
Elucidation of Triacylglycerol Overproduction in the C4 Bioenergy Crop Sorghum bicolor by Constraint-Based Analysis Open
Upregulation of triacylglycerols (TAGs) in vegetative plant tissues such as leaves has the potential to drastically increase the energy density and biomass yield of bioenergy crops. In this context, constraint-based analysis has the promis…
View article: Cellular Plasticity in Response to Suppression of Storage Proteins in the <i>Brassica napus</i> Embryo
Cellular Plasticity in Response to Suppression of Storage Proteins in the <i>Brassica napus</i> Embryo Open
The tradeoff between protein and oil storage in oilseed crops has been tested here in oilseed rape (Brassica napus) by analyzing the effect of suppressing key genes encoding protein storage products (napin and cruciferin). The pheno…
View article: Modeling Plant Metabolism: From Network Reconstruction to Mechanistic Models
Modeling Plant Metabolism: From Network Reconstruction to Mechanistic Models Open
Mathematical modeling of plant metabolism enables the plant science community to understand the organization of plant metabolism, obtain quantitative insights into metabolic functions, and derive engineering strategies for manipulation of …
View article: An Expanded Role for WRINKLED1 Metabolic Control Based on Combined Phylogenetic and Biochemical Analyses
An Expanded Role for WRINKLED1 Metabolic Control Based on Combined Phylogenetic and Biochemical Analyses Open
During triacylglycerol biosynthesis in developing oilseeds of Arabidopsis thaliana , fatty acid production is regulated by the seed-specific transcription factor WRINKLED1 (WRI1). WRI1 is known to directly stimulate the expression of fatty…
View article: Role of cellular architecture in protein re-balancing of the Brassica napus embryo
Role of cellular architecture in protein re-balancing of the Brassica napus embryo Open
The trade-off between protein and oil storage in oilseed crops has been tested here in oilseed rape (Brassica napus) by analyzing the effect of suppressing key genes encoding protein storage products (napin, cruciferin). The phenotypic out…
View article: WRINKLED1 Regulates BIOTIN ATTACHMENT DOMAIN-CONTAINING Proteins that Inhibit Fatty Acid Synthesis
WRINKLED1 Regulates BIOTIN ATTACHMENT DOMAIN-CONTAINING Proteins that Inhibit Fatty Acid Synthesis Open
WRINKLED1 (WRI1) is a transcriptional activator that binds to a conserved sequence (designated as AW box) boxes in the promoters of many genes from central metabolism and fatty acid (FA) synthesis, resulting in their transcription. BIOTIN …
View article: Expression of a Lychee <i>PHOSPHATIDYLCHOLINE:DIACYLGLYCEROL CHOLINEPHOSPHOTRANSFERASE</i> with an <i>Escherichia coli CYCLOPROPANE SYNTHASE</i> Enhances Cyclopropane Fatty Acid Accumulation in Camelina Seeds
Expression of a Lychee <i>PHOSPHATIDYLCHOLINE:DIACYLGLYCEROL CHOLINEPHOSPHOTRANSFERASE</i> with an <i>Escherichia coli CYCLOPROPANE SYNTHASE</i> Enhances Cyclopropane Fatty Acid Accumulation in Camelina Seeds Open
Cyclopropane fatty acids (CPAs) are useful feedstocks for biofuels and bioproducts such as lubricants and biodiesel. Our goal is to identify factors that can facilitate the accumulation of CPA in seed triacylglycerol (TAG) storage oil. We …
View article: BIOTIN ATTACHMENT DOMAIN-CONTAINING proteins, inhibitors of ACCase, are regulated by WRINKLED1
BIOTIN ATTACHMENT DOMAIN-CONTAINING proteins, inhibitors of ACCase, are regulated by WRINKLED1 Open
WRINKLED1 (WRI1) is a transcriptional activator that binds to AW boxes in the promoters of many genes from central metabolism and FA synthesis, resulting in their transcription. BIOTIN ATTACHMENT DOMAIN-CONTAINING (BADC) proteins are homol…
View article: The role of alanine and aspartate aminotransferases in C<sub>4</sub> photosynthesis
The role of alanine and aspartate aminotransferases in C<sub>4</sub> photosynthesis Open
Alanine and aspartate are essential transfer metabolites for C 4 species of the NAD ‐malic enzyme and phosphoenolpyruvate carboxykinase subtype. To some degree both amino acids are also part of the metabolite shuttle in NADP ‐malic enzyme …
View article: Identification of bottlenecks in the accumulation of cyclic fatty acids in camelina seed oil
Identification of bottlenecks in the accumulation of cyclic fatty acids in camelina seed oil Open
Summary Modified fatty acids ( mFA ) have diverse uses; for example, cyclopropane fatty acids ( CPA ) are feedstocks for producing coatings, lubricants, plastics and cosmetics. The expression of mFA ‐producing enzymes in crop and model pla…
View article: Mathematical models of plant metabolism
Mathematical models of plant metabolism Open
View article: Increase of Rapeseed Oil Yield Using a Systems Biology Approach
Increase of Rapeseed Oil Yield Using a Systems Biology Approach Open
This project aims to develop the knowledge and skills required for obtaining increased amounts of plant oils for the production of biofuel. The systems-oriented analysis of the developing seed has a clear focus on storage metabolism and ca…
View article: Quantitative Multilevel Analysis of Central Metabolism in Developing Oilseeds of Oilseed Rape during in Vitro Culture
Quantitative Multilevel Analysis of Central Metabolism in Developing Oilseeds of Oilseed Rape during in Vitro Culture Open
Seeds provide the basis for many food, feed, and fuel products. Continued increases in seed yield, composition, and quality require an improved understanding of how the developing seed converts carbon and nitrogen supplies into storage. Cu…