Explanipedia

Effectiveness and implementation of an inpatient mental health care pathway at an epilepsy center: A prospective service evaluation Open

R. Michaelis, Dorothea Hölscher, Katharina Braun, Sabine Schlömer, Wenke Grönheit , et al. · 2025

Objectives This hybrid study assessed the implementation and clinical effectiveness of a structured mental health care workflow for epilepsy. Methods Eligible inpatients were screened systematically. Patients with scores above cutoff score…

Explanations for Medical Diagnosis Predictions Based on Argumentation Schemes Open

Felix Liedeker, Olivia Sanchez-Graillet, Christian Brandt, Jörg Wellmer, Philipp Cimiano · 2025

As (explainable) artificial intelligence becomes increasingly integrated into high-stakes domains like healthcare, it is paramount to understand what makes explanations effective and convincing. In this work, we propose an approach that in…

Changes in brain network dynamics during functional/dissociative seizures: An exploratory pilot study on EEG microstates Open

Domantė Kučikienė, Johannes Jungilligens, Stefan Wolking, Yvonne Weber, Jörg Wellmer , et al. · 2025

The pathophysiology of functional/dissociative seizures (FDS), also known as psychogenic nonepileptic seizures, remains incompletely understood. Current theories suggest that ictal changes in self-awareness and behavioural control are like…

Introducing the Concept of Error Vectors to Improve Source Localization Results of Epileptic Discharges Open

Kanjana Unnwongse, Carsten H. Wolters, Tim Wehner, Lawrence Kruger, Stefan Rampp , et al. · 2025

Purpose: To improve EEG source localization results of interictal epileptic discharges (IED) by applying postprocessing step to electrical source imaging (ESI). Methods: Localization error of ESI was evaluated in comparison to known source…

Respiratory modulations of cortical excitability and interictal spike timing in focal epilepsy: a case report Open

Daniel S. Kluger, Tim Erdbrügger, Christina Stier, Malte B. Höltershinken, Omid Abbasi , et al. · 2025

Background Brain activity in focal epilepsy is marked by a pronounced excitation-inhibition (E:I) imbalance and interictal epileptiform discharges (IEDs) observed in periods between recurrent seizures. As a marker of E:I balance, aperiodic…

The role of the precuneus in dissociative seizures: A structural neuroimaging study Open

Leonie Helmstaedter, Stoyan Popkirov, Jörg Wellmer, Corinna Seliger, Johannes Jungilligens · 2025

The neurobiology and neuropsychology of dissociative seizures is increasingly well understood, but a gap remains in understanding the neurobiological underpinnings of one of its core features: dissociation. As a transdiagnostic phenomenon,…

Multimodal tele-epileptology: Challenges on the way to interoperable medical data Open

Sigrid Mues, Alexandria R. Ebert, M. Kämmerer, Marjolein N. T. Kremers, Ulrich Sliwka , et al. · 2025

Genuine interoperability of medical data remains the desired goal for multi modal data exchange.

Heartbeat evoked potentials and autonomic arousal during dissociative seizures: insights from electrophysiology and neuroimaging Open

Vera Flasbeck, Johannes Jungilligens, Isabell Lemke, Jule Beckers, Hilal Öztürk , et al. · 2024

Introduction Dissociative seizures often occur in the context of dysregulated affective arousal and entail dissociative symptoms such as a disintegration of bodily awareness. However, the interplay between affective arousal and changes in …

A multicenter randomized controlled feasibility trial of a digital self‐management intervention for adults with epilepsy Open

R. Michaelis, Susanne Knake, Felix Rosenow, Wenke Grönheit, Hajo M. Hamer , et al. · 2024

Objective Self‐management interventions may enhance health‐related quality of life (HRQoL) in epilepsy. However, several barriers often impair their implementation in the real world. Digital interventions may help to overcome some of these…

Defining benchmark outcomes for mesial temporal lobe epilepsy surgery: A global multicenter analysis of 1119 cases Open

Richard Drexler, Franz Ricklefs, Sharona Ben‐Haim, Anna Rada, Friedrich G. Wörmann , et al. · 2024

Objective Benchmarking has been proposed to reflect surgical quality and represents the highest standard reference values for desirable results. We sought to determine benchmark outcomes in patients after surgery for drug‐resistant mesial …

Standardized hierarchical adaptive Lp regression for noise robust focal epilepsy source reconstructions Open

Joonas Lahtinen, Alexandra Koulouri, Stefan Rampp, Jörg Wellmer, Carsten H. Wolters , et al. · 2023

The proposed standardized methodology, especially when employing the L1-norm, could serve as a valuable assessment tool in surgical decision-making.

Heartbeat evoked potentials and autonomic arousal during dissociative seizures Open

Vera Flasbeck, Johannes Jungilligens, Jule Beckers, Jörg Wellmer, Stoyan Popkirov · 2023

Dissociative seizures often occur in the context of dysregulated affective arousal and entail dissociative symptoms such as a disintegration of bodily awareness. However, the interplay between affective arousal and changes in interoceptive…

Dissociative seizures in the emergency room: room for improvement Open

Ozan Cengiz, Johannes Jungilligens, R. Michaelis, Jörg Wellmer, Stoyan Popkirov · 2023

Background Dissociative seizures, also known as functional or psychogenic non-epileptic seizures, account for 11%–27% of all emergency seizure presentations. Misdiagnosis as epileptic seizures is common and leads to ineffective and potenti…

Respiratory modulations of cortical excitability and interictal spike timing in focal epilepsy - a case report Open

Daniel S. Kluger, Tim Erdbrügger, Christina Stier, Malte B. Höltershinken, Omid Abbasi , et al. · 2023

Summary Brain activity in focal epilepsy is marked by a pronounced excitation-inhibition (E:I) imbalance and interictal epileptiform discharges (IEDs) observed in periods between recurrent seizures. As a marker of E:I balance, aperiodic ne…

Validating EEG source imaging using intracranial electrical stimulation Open

Kanjana Unnwongse, Stefan Rampp, Tim Wehner, Annika Kowoll, Yaroslav Parpaley , et al. · 2022

Electrical source imaging is used in presurgical epilepsy evaluation and in cognitive neurosciences to localize neuronal sources of brain potentials recorded on EEG. This study evaluates the spatial accuracy of electrical source imaging fo…

Teaching distinguishing semiological features improves diagnostic accuracy of seizure-like events by emergency physicians Open

Wenke Grönheit, Vanessa Behrens, Tatjana Liakina, Christoph Kellinghaus, Soheyl Noachtar , et al. · 2022

Background Misdiagnosis of seizure-like events (SLE) in emergency situations is common. Here, we evaluate whether a single, video-based lesson highlighting distinguishing semiological features can improve the diagnostic accuracy of emergen…

Brain tumor related epilepsy: pathophysiological approaches and rational management of antiseizure medication Open

Sabine Seidel, Tim Wehner, Dorothea Miller, Jörg Wellmer, Uwe Schlegel , et al. · 2022

Point-of-Care Testing Using a Neuropsychology Pocketcard Set: A Preliminary Validation Study Open

Emily Bellartz, Milena Pertz, Johannes Jungilligens, Ilka Kleffner, Jörg Wellmer , et al. · 2022

Neurocognitive screening instruments usually require printed sheets and additional accessories, and can be unsuitable for low-threshold use during ward rounds or emergency workup, especially in patients with motor impairments. Here, we tes…

A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies Open

Christine Strippel, Marisol Herrera-Rivero, Mareike Wendorff, Anja Tietz, Frauke Degenhardt , et al. · 2022

Autoimmune neurological syndromes (AINS) with autoantibodies against the 65 kDa isoform of the glutamic acid decarboxylase (GAD65) present with limbic encephalitis, including temporal lobe seizures or epilepsy, cerebellitis with ataxia, an…

Cortical thickness in default mode network hubs correlates with clinical features of dissociative seizures Open

Lada Zelinski, Ibai Díez, David L. Perez, Sonja A. Kotz, Jörg Wellmer , et al. · 2022

Validating EEG, MEG and Combined MEG and EEG Beamforming for an Estimation of the Epileptogenic Zone in Focal Cortical Dysplasia Open

Frank Neugebauer, Marios Antonakakis, Kanjana Unnwongse, Yaroslav Parpaley, Jörg Wellmer , et al. · 2022

MEG and EEG source analysis is frequently used for the presurgical evaluation of pharmacoresistant epilepsy patients. The source localization of the epileptogenic zone depends, among other aspects, on the selected inverse and forward appro…

Enhancing Safety in Epilepsy Surgery (EASINESS): Study Protocol for a Retrospective, Multicenter, Open Registry Open

Richard Drexler, Sharona Ben‐Haim, Christian G. Bien, Valeri Borger, Francesco Cardinale , et al. · 2021

Introduction: Optimizing patient safety and quality improvement is increasingly important in surgery. Benchmarks and clinical quality registries are being developed to assess the best achievable results for several surgical procedures and …

Validating EEG, MEG and combined MEG and EEG beamforming for an estimation of the epileptogenic zone in focal cortical dysplasia Open

Frank Neugebauer, Marios Antonakakis, Kanjana Unnwongse, Yaroslav Parpaley, Jörg Wellmer , et al. · 2021

MEG and EEG source analysis is frequently used for the presurgical evaluation of pharma-coresistant epilepsy patients. The source localization of the epileptogenic zone depends, among other aspects, on the selected inverse and forward appr…

Screening for Psychiatric Comorbidities and Psychotherapeutic Assessment in Inpatient Epilepsy Care: Preliminary Results of an Implementation Study Open

R. Michaelis, Sabine Schlömer, Anja Lindemann, Vanessa Behrens, Wenke Grönheit , et al. · 2021

Background: Anxiety and depression remain underdiagnosed in routine clinical practice in up to two thirds of epilepsy patients despite significant impact on medical and psychosocial outcome. Barriers to adequate mental health care for epil…

Factors influencing the detection of treatable epileptogenic lesions on MRI. A randomized prospective study Open

Tim Wehner, Philippe Weckesser, Steven Schulz, Annika Kowoll, Sebastian Fischer , et al. · 2021

Diagnostic challenges in patients with temporal lobe seizures and features of autoimmune limbic encephalitis Open

Fatme Seval Ismail, Marianna Spatola, Friedrich G. Woermann, Stoyan Popkirov, Johannes Jungilligens , et al. · 2021

Background and purpose Consensus criteria for autoimmune limbic encephalitis (ALE) allow for a diagnosis even without neuronal antibodies (Abs), but it remains unclear which clinical features should prompt neuronal Ab screening in temporal…

Tele-Epileptologie Ruhr: Zwischenevaluation eines telemedizinischen Modellprojektes Open

Sigrid Mues, Wenke Grönheit, Tim Wehner, Jörg Wellmer · 2021

Zusammenfassung Hintergrund Diagnose und Behandlung von Patienten mit Epilepsie oder anderen anfallsartig auftretenden Symptomen erfordert in manchen Situationen Spezialistenwissen. Um dieses auch Abteilungen ohne eigene spezialisierte Epi…

Telemedizin in der Epilepsieversorgung: Arzt-zu-Arzt-Anwendungen Open

Sigrid Mues, Hajo M. Hamer, Felix von Podewils, Ali Sotoodeh, Felix Rosenow , et al. · 2021

Zusammenfassung Hintergrund In den vergangenen 10 Jahren wurden an verschiedenen Epilepsiezentren in Deutschland (Bochum, Erlangen, Greifswald, Berlin Brandenburg, Frankfurt Rhein-Main) Projekte entwickelt, die sich mit telemedizinischen A…

Telemedizin in der Epilepsieversorgung: Arzt-zu-Arzt-Anwendungen Open

Sigrid Mues, Hajo M. Hamer, Felix von Podewils, Ali Sotoodeh, Felix Rosenow , et al. · 2021

Zusammenfassung Telemedizinische Arzt-zu-Arzt-Anwendungen in der Epilepsieversorgung können helfen, die spezielle Expertise von neurologischen oder pädiatrischen EpileptologInnen flächendeckend vorzuhalten, da sie es ermöglichen, medizinis…

External validation of automated focal cortical dysplasia detection using morphometric analysis Open

Bastian David, Judith Kröll‐Seger, Fabiane Schuch, Jan Wagner, Jörg Wellmer , et al. · 2021

Objective Focal cortical dysplasias (FCDs) are a common cause of drug‐resistant focal epilepsy but frequently remain undetected by conventional magnetic resonance imaging (MRI) assessment. The visual detection can be facilitated by morphom…

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