Jörg Zimmermann
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View article: Resistive Plate Chamber detector construction and certification: state-of-the-art facilities at the Max Planck Institute for Physics, in partnership with industrial partners
Resistive Plate Chamber detector construction and certification: state-of-the-art facilities at the Max Planck Institute for Physics, in partnership with industrial partners Open
Resistive Plate Chambers (RPCs) featuring 1 mm gas volumes combined with high-pressure phenolic laminate (HPL) electrodes provide excellent timing resolution down to a few hundred picoseconds, along with spatial resolution on the order of …
View article: The Photophysical Properties of the Protonation States of SYPRO® Orange in Aqueous Solution
The Photophysical Properties of the Protonation States of SYPRO® Orange in Aqueous Solution Open
SYPRO® Orange (SyO) is a zwitterionic dye that is used for protein gel staining, for thermal melt assays of proteins, and as a marker for misfolded proteins. However, while widely utilized, much of SyOs’ photophysics remains unexplored. We…
View article: Integrative Analysis of miRNA Expression Profiles Reveals Distinct and Common Molecular Mechanisms Underlying Broad Diagnostic Groups of Severe Mental Disorders
Integrative Analysis of miRNA Expression Profiles Reveals Distinct and Common Molecular Mechanisms Underlying Broad Diagnostic Groups of Severe Mental Disorders Open
Micro RNAs (miRNAs) play a crucial role as regulators of various biological processes and have been implicated in the pathogenesis of mental disorders such as schizophrenia and bipolar disorders. In this study, we investigate the expressio…
View article: Machine learning models for predicting severe COVID-19 outcomes in hospitals
Machine learning models for predicting severe COVID-19 outcomes in hospitals Open
The aim of this observational retrospective study is to improve early risk stratification of hospitalized Covid-19 patients by predicting in-hospital mortality, transfer to intensive care unit (ICU) and mechanical ventilation from electron…
View article: Machine learning models for predicting severe COVID-19 outcomes in hospitals
Machine learning models for predicting severe COVID-19 outcomes in hospitals Open
The aim of this observational retrospective study is to improve early risk stratification of hospitalized Covid-19 patients by predicting in-hospital mortality, transfer to intensive care unit (ICU) and mechanical ventilation from electron…
View article: Patterns of convergent somatic hypermutations in the adaptive immune response of Mus musculus
Patterns of convergent somatic hypermutations in the adaptive immune response of Mus musculus Open
We analyzed a dataset of 964 clonally unrelated murine antibodies for which structures have been deposited in the PDB. 454 of the 964 antibodies have gapless germline assignments and do not have excessive numbers of computationally identif…
View article: Direct Observation of Peptide Hydrogel Self-Assembly
Direct Observation of Peptide Hydrogel Self-Assembly Open
The characterization of self-assembling molecules presents significant experimental challenges, especially when associated with phase separation or precipitation. Transparent window infrared (IR) spectroscopy leverages site-specific probes…
View article: Direct observation of peptide hydrogel self-assembly
Direct observation of peptide hydrogel self-assembly Open
To facilitate the characterization of phase-transitioning molecules, site-specific non-perturbative infrared probes are leveraged for continuous observation of the self-assembly of fibrils in a peptide hydrogel following stopped-flow initi…
View article: Direct Observation of Peptide Hydrogel Self-Assembly
Direct Observation of Peptide Hydrogel Self-Assembly Open
The characterization of self-assembling molecules presents significant experimental challenges, especially when associated with phase separation or precipitation. Transparent window infrared (IR) spectroscopy leverages site-specific probes…
View article: Structure and Dynamics of Stacking Interactions in an Antibody Binding Site
Structure and Dynamics of Stacking Interactions in an Antibody Binding Site Open
For years, antibodies (Abs) have been used as a paradigm for understanding how protein structure contributes to molecular recognition. However, with the ability to evolve Abs that recognize specific chromophores, they also have great poten…
View article: Cover Image, Volume 180B, Number 2, March 2019
Cover Image, Volume 180B, Number 2, March 2019 Open
The cover image is based on the Research Article A longitudinal approach to biological psychiatric research: The PsyCourse study by Monika Budde et al., DOI: 10.1002/ajmg.b.32639.
View article: A Peroxygenase from <i>Chaetomium globosum</i> Catalyzes the Selective Oxygenation of Testosterone
A Peroxygenase from <i>Chaetomium globosum</i> Catalyzes the Selective Oxygenation of Testosterone Open
Unspecific peroxygenases (UPO, EC 1.11.2.1) secreted by fungi open an efficient way to selectively oxyfunctionalize diverse organic substrates, including less‐activated hydrocarbons, by transferring peroxide‐borne oxygen. We investigated a…
View article: Adaptive Mutations Alter Antibody Structure and Dynamics during Affinity Maturation
Adaptive Mutations Alter Antibody Structure and Dynamics during Affinity Maturation Open
While adaptive mutations can bestow new functions on proteins via the introduction or optimization of reactive centers, or other structural changes, a role for the optimization of protein dynamics also seems likely but has been more diffic…