Jorge A. Peña Agudelo
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View article: Autophagy Upregulation in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma Uncovers a Novel Therapeutic Target
Autophagy Upregulation in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma Uncovers a Novel Therapeutic Target Open
View article: Integrated Workflow for Drug Repurposing in Glioblastoma: Computational Prediction and Preclinical Validation of Therapeutic Candidates
Integrated Workflow for Drug Repurposing in Glioblastoma: Computational Prediction and Preclinical Validation of Therapeutic Candidates Open
Background: Glioblastoma (GBM) remains a significant challenge in oncology due to its resistance to standard treatments including temozolomide. This study aimed to develop and validate an integrated model for predicting GBM sensitivity to …
View article: Predicting Treatment Outcomes in Glioblastoma: A Risk Score Model for TMZ Resistance and Immune Checkpoint Inhibition
Predicting Treatment Outcomes in Glioblastoma: A Risk Score Model for TMZ Resistance and Immune Checkpoint Inhibition Open
Glioblastoma (GBM) presents significant therapeutic challenges due to its invasive nature and resistance to standard chemotherapy, i.e., temozolomide (TMZ). This study aimed to identify gene signatures that predict poor TMZ response and hi…
View article: Targeting Foxp3 in Glioblastoma: Blockade of Tumor Intrinsic Effects Boosts Response to Chemo-Radiotherapy
Targeting Foxp3 in Glioblastoma: Blockade of Tumor Intrinsic Effects Boosts Response to Chemo-Radiotherapy Open
View article: Identification and validation of drugs for repurposing in Glioblastoma: a computational and experimental workflow
Identification and validation of drugs for repurposing in Glioblastoma: a computational and experimental workflow Open
Purpose Glioblastoma (GBM) remains a formidable challenge in oncology due to its invasiveness and resistance to treatment, i.e. surgery, radiotherapy, and chemotherapy with temozolomide. This study aimed to develop and validate an integrat…
View article: Identification and validation of drugs for repurposing in Glioblastoma: a computational and experimental workflow
Identification and validation of drugs for repurposing in Glioblastoma: a computational and experimental workflow Open
Purpose Glioblastoma (GBM) remains a formidable challenge in oncology due to its invasiveness and resistance to treatment, i.e. surgery, radiotherapy, and chemotherapy with temozolomide. This study aimed to develop and validate an integrat…
View article: GK-1 effectively reduces angiogenesis and prevents T cell exhaustion in a breast cancer murine experimental model
GK-1 effectively reduces angiogenesis and prevents T cell exhaustion in a breast cancer murine experimental model Open
Breast cancer is the leading malignancy in women worldwide, both in terms of incidence and mortality. Triple-negative breast cancer (TNBC) is the type with the worst clinical outcomes and with fewer therapeutic options than other types of …
View article: Targeting FOXP3 Tumor-Intrinsic Effects Using Adenoviral Vectors in Experimental Breast Cancer
Targeting FOXP3 Tumor-Intrinsic Effects Using Adenoviral Vectors in Experimental Breast Cancer Open
The regulatory T cell master transcription factor, Forkhead box P3 (Foxp3), has been detected in cancer cells; however, its role in breast tumor pathogenesis remains controversial. Here we assessed Foxp3 tumor intrinsic effects in experime…
View article: Mitochondrial Peptide Humanin Facilitates Chemoresistance in Glioblastoma Cells
Mitochondrial Peptide Humanin Facilitates Chemoresistance in Glioblastoma Cells Open
Humanin (HN) is a mitochondrial-derived peptide with robust cytoprotective effects in many cell types. Although the administration of HN analogs has been proposed to treat degenerative diseases, its role in the pathogenesis of cancer is po…
View article: Targeting Foxp3 Tumor Intrinsic Effects Using Adenoviral Vectors in Experimental Breast Cancer
Targeting Foxp3 Tumor Intrinsic Effects Using Adenoviral Vectors in Experimental Breast Cancer Open
Regulatory T cell master transcription factor, Forkhead box P3 (Foxp3) has been detected in cancer cells, but its role in breast tumor pathogenesis remains controversial. Here we assessed Foxp3 tumor intrinsic effects in experimental breas…
View article: Evaluation of Baculoviruses as Gene Therapy Vectors for Brain Cancer
Evaluation of Baculoviruses as Gene Therapy Vectors for Brain Cancer Open
We aimed to assess the potential of baculoviral vectors (BV) for brain cancer gene therapy. We compared them with adenoviral vectors (AdV), which are used in neuro-oncology, but for which there is pre-existing immunity. We constructed BVs …