Jorge H. Capdevila
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View article: Supplementary Data from The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production
Supplementary Data from The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production Open
This file contains the primer sequence of CYP2C9* variants (Supplementary Table S1); the SNPs genotyped in the BioVU NSCLC study (Supplementary Table S2); quality control measures of SNPs in the BioVU NSCLC study (Supplementary Table S3); …
View article: Supplementary Data from The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production
Supplementary Data from The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production Open
This file contains the primer sequence of CYP2C9* variants (Supplementary Table S1); the SNPs genotyped in the BioVU NSCLC study (Supplementary Table S2); quality control measures of SNPs in the BioVU NSCLC study (Supplementary Table S3); …
View article: Data from The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production
Data from The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production Open
Increased expression of cytochrome P450 CYP2C9, together with elevated levels of its products epoxyeicosatrienoic acids (EET), is associated with aggressiveness in cancer. Cytochrome P450 variants CYP2C9*2 and CYP2C9*3 encode proteins with…
View article: Data from The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production
Data from The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production Open
Increased expression of cytochrome P450 CYP2C9, together with elevated levels of its products epoxyeicosatrienoic acids (EET), is associated with aggressiveness in cancer. Cytochrome P450 variants CYP2C9*2 and CYP2C9*3 encode proteins with…
View article: Supplementary Figure Legend from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer
Supplementary Figure Legend from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer Open
PDF file - 68K
View article: Data from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer
Data from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer Open
Non–small cell lung cancer (NSCLC) not amenable to surgical resection has a high mortality rate, due to the ineffectiveness and toxicity of chemotherapy. Thus, there remains an urgent need of efficacious drugs that can combat this disease.…
View article: Supplementary Figure Legend from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer
Supplementary Figure Legend from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer Open
PDF file - 68K
View article: Supplementary Figure 1 from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer
Supplementary Figure 1 from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer Open
PDF file - 24K, Analysis of p60.5 and KrasLA2 tumor cells.
View article: Supplementary Figure 1 from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer
Supplementary Figure 1 from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer Open
PDF file - 24K, Analysis of p60.5 and KrasLA2 tumor cells.
View article: Supplementary Figure 2 from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer
Supplementary Figure 2 from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer Open
PDF file - 99K, Analysis of human GFP-A549 NSCLC tumor cells.
View article: Supplementary Figure 3 from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer
Supplementary Figure 3 from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer Open
PDF file - 40K, Treatment of athymic mice orthotopically injected with human GFP-A549 cells with Bezafibrate.
View article: Supplementary Figure 3 from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer
Supplementary Figure 3 from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer Open
PDF file - 40K, Treatment of athymic mice orthotopically injected with human GFP-A549 cells with Bezafibrate.
View article: Data from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer
Data from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer Open
Non–small cell lung cancer (NSCLC) not amenable to surgical resection has a high mortality rate, due to the ineffectiveness and toxicity of chemotherapy. Thus, there remains an urgent need of efficacious drugs that can combat this disease.…
View article: Supplementary Figure 2 from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer
Supplementary Figure 2 from PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer Open
PDF file - 99K, Analysis of human GFP-A549 NSCLC tumor cells.
View article: Thematic Review Series: Living History of Lipids The arachidonic acid monooxygenase: from biochemical curiosity to physiological/pathophysiological significance
Thematic Review Series: Living History of Lipids The arachidonic acid monooxygenase: from biochemical curiosity to physiological/pathophysiological significance Open
The initial studies of the metabolism of arachidonic acid (AA) by the cytochrome P450 (P450) hemeproteins sought to: a) elucidate the roles for these enzymes in the metabolism of endogenous pools of the FA, b) identify the P450 isoforms in…
View article: High-fat diet-induced obesity and insulin resistance in CYP4a14<sup>−/−</sup> mice is mediated by 20-HETE
High-fat diet-induced obesity and insulin resistance in CYP4a14<sup>−/−</sup> mice is mediated by 20-HETE Open
20-Hydroxyeicosatetraenoic acid (20-HETE) has been shown to positively correlate with body mass index, hyperglycemia, and plasma insulin levels. This study seeks to identify a causal relationship between 20-HETE and obesity-driven insulin …
View article: <i>Cyp2c44</i>gene disruption is associated with increased hematopoietic stem cells: implication in chronic hypoxia-induced pulmonary hypertension
<i>Cyp2c44</i>gene disruption is associated with increased hematopoietic stem cells: implication in chronic hypoxia-induced pulmonary hypertension Open
We have recently demonstrated that disruption of the murine cytochrome P-450 2c44 gene ( Cyp2c44) exacerbates chronic hypoxia-induced pulmonary artery remodeling and hypertension in mice. Subsequently, we serendipitously found that Cyp2c44…
View article: 20-HETE Signals Through G-Protein–Coupled Receptor GPR75 (G <sub>q</sub> ) to Affect Vascular Function and Trigger Hypertension
20-HETE Signals Through G-Protein–Coupled Receptor GPR75 (G <sub>q</sub> ) to Affect Vascular Function and Trigger Hypertension Open
Rationale: 20-Hydroxyeicosatetraenoic acid (20-HETE), one of the principle cytochrome P450 eicosanoids, is a potent vasoactive lipid whose vascular effects include stimulation of smooth muscle contractility, migration, and proliferation, a…
View article: Abstract 44: Hexyl-benzyl-biguanide (HBB) potently and selectively inhibits CYP3A4 epoxygenase activity and inhibits EET stabilization of mitochondrial respiration in ER+HER2- breast cancer cells, inducing glycolysis and pyruvate biosynthesis
Abstract 44: Hexyl-benzyl-biguanide (HBB) potently and selectively inhibits CYP3A4 epoxygenase activity and inhibits EET stabilization of mitochondrial respiration in ER+HER2- breast cancer cells, inducing glycolysis and pyruvate biosynthesis Open
Cytochrome P450 3A4 (CYP3A4) promotes ER+HER2- breast cancer cell proliferation and survival, in part, by biosynthesis of epoxyeicosatrienoic acids (EETs). EETs are known to regulate mitochondrial function in non-transformed cells, but the…
View article: <i>Cyp2c44</i> Gene Disruption Exacerbated Pulmonary Hypertension and Heart Failure in Female but Not Male Mice
<i>Cyp2c44</i> Gene Disruption Exacerbated Pulmonary Hypertension and Heart Failure in Female but Not Male Mice Open
Epoxyeicosatrienoicacids (EETs), synthesized from arachidonic acid by epoxygenases of the CYP2C and CYP2J gene subfamilies, contribute to hypoxic pulmonary vasoconstriction (HPV) in mice. Despite their roles in HPV, it is controversial whe…
View article: 20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice
20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice Open
Male and female homozygous 129/Sv mice carrying four copies of the human cytochrome P450 4A11 gene (CYP4A11) under control of its native promoter (B-129/Sv-4A11(+/+)) develop hypertension (142 ± 8 versus 113 ± 7 mm Hg systolic blood pressu…