Jorge Alberto Cortés
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View article: Olutasidenib for mutated IDH1 acute myeloid leukemia: final five-year results from the phase 2 pivotal cohort
Olutasidenib for mutated IDH1 acute myeloid leukemia: final five-year results from the phase 2 pivotal cohort Open
NCT02719574.
View article: Dosing patterns of ponatinib in patients with chronic-Phase chronic myeloid leukemia and effect on treatment: Analysis of specialty pharmacy data in the United States
Dosing patterns of ponatinib in patients with chronic-Phase chronic myeloid leukemia and effect on treatment: Analysis of specialty pharmacy data in the United States Open
Introduction Ponatinib, the only BCR::ABL1 TKI with no contraindicated mutations, has been evaluated in patients (pts) with chronic-phase chronic myeloid leukemia (CP-CML) in two large, global, phase 2 studies. The PACE study (NCT01207440)…
View article: Prediction Score for Identification of ESBL Producers in Urinary Infections Overestimates Risk in High-ESBL-Prevalence Setting
Prediction Score for Identification of ESBL Producers in Urinary Infections Overestimates Risk in High-ESBL-Prevalence Setting Open
Background/Objectives: Urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase (ESBL) Enterobacterales have become more frequent. Therefore, strategies for assessing the risks posed by ESBL-producing infections have been…
View article: Clinical Outcomes of Critically Ill Patients with Candida spp. Peritonitis: A Retrospective Cohort Study
Clinical Outcomes of Critically Ill Patients with Candida spp. Peritonitis: A Retrospective Cohort Study Open
Introduction/objectives: Peritonitis resulting from Candida spp. is common among critically ill patients and has been associated with adverse clinical outcomes. This study aimed to determine the effects of isolates of Candida species in pa…
View article: Epidemiological Genomics of Klebsiella pneumoniae isolates from hospitals across Colombia
Epidemiological Genomics of Klebsiella pneumoniae isolates from hospitals across Colombia Open
Klebsiella pneumoniae is one of the most important nosocomial pathogens worldwide. In Colombia, K. pneumoniae has been identified as the second most frequent microbial etiologic agent of healthcare-associated infections. We conducted a pro…
View article: A deep dive into the surgical and pharmacological considerations of obesity in chronic myeloid leukemia: a narrative review
A deep dive into the surgical and pharmacological considerations of obesity in chronic myeloid leukemia: a narrative review Open
Background/Objectives The rising prevalence of obesity presents significant challenges in managing chronic myeloid leukemia (CML). Bariatric surgery alters the bioavailability of oral medications, necessitating tailored treatment strategie…
View article: Knowledge for a thriving ocean
Knowledge for a thriving ocean Open
Geopolitical shifts are fracturing global agendas, sidelining Sustainable Development Goals as well as climate and biodiversity commitments. This is especially risky for the ocean, a key climate regulator and biodiversity hub that has the …
View article: Cost-effectiveness analysis of second-line medical therapies in acromegaly: a real-life study
Cost-effectiveness analysis of second-line medical therapies in acromegaly: a real-life study Open
Introduction Acromegaly is an uncommon disease with important comorbidity and economic cost. Although the pharmacological cost of second-line treatment for refractory acromegaly has been theoretically analyzed, real-life studies are needed…
View article: Key success factors in clinical trial operation of the smallpox vaccine LC16m8 against mpox in Colombia
Key success factors in clinical trial operation of the smallpox vaccine LC16m8 against mpox in Colombia Open
In 2023, the Japan Institute for Health Security (JIHS) and the Universidad Nacional de Colombia (UNAL) conducted a successful clinical trial of the LC16m8 mpox vaccine in Colombia. The joint Japan-Colombia research team categorized the tr…
View article: Multiplex PCR Pneumonia Panel in Critically Ill Patients Did Not Modify Mortality: A Cohort Study
Multiplex PCR Pneumonia Panel in Critically Ill Patients Did Not Modify Mortality: A Cohort Study Open
In critically ill patients, identification of the pathogen may allow for the timely adjustment of antibiotics and improved outcomes. Background/Objectives: The aim of the study was to assess whether performing a multiplex PCR pneumonia pan…
View article: FungiCAP Survey: Insights Into Physicians' Knowledge, Attitudes and Practices in Antifungal Prescriptions in Colombia
FungiCAP Survey: Insights Into Physicians' Knowledge, Attitudes and Practices in Antifungal Prescriptions in Colombia Open
Introduction The main objective of this study was to evaluate the knowledge, attitudes, and practices of physicians related to the prescription of antifungals in a Latin American country. Materials and Methods A close survey of Colombian p…
View article: Impact of Antibiotic Therapy with Ceftazidime Avibactam vs. Best Available Therapy in Adult Patients with Bacteremia Caused by Carbapenem-Resistant Enterobacterales
Impact of Antibiotic Therapy with Ceftazidime Avibactam vs. Best Available Therapy in Adult Patients with Bacteremia Caused by Carbapenem-Resistant Enterobacterales Open
Background/Objectives: Carbapenem-resistant Enterobacterales (CRE) infection is associated with a higher mortality rate. The purpose of this study was to evaluate the effect of ceftazidime avibactam (CZA) for treating bacteremia caused by …
View article: Effect of Inadequate Treatment in Adult Patients with Community-Acquired Acute Pyelonephritis Due to Enterobacterales Under Empirical Management with Cefazolin
Effect of Inadequate Treatment in Adult Patients with Community-Acquired Acute Pyelonephritis Due to Enterobacterales Under Empirical Management with Cefazolin Open
Background/Objectives: First-generation cephalosporins are used in some countries, primarily in Latin America and other low-resource regions, as a first-line or alternative empirical treatment for patients with acute pyelonephritis (AP). T…
View article: P-2243. Multiplex PCR Pneumonia Panel in Critically Ill Patients Did Not Modify Mortality. A Cohort Study
P-2243. Multiplex PCR Pneumonia Panel in Critically Ill Patients Did Not Modify Mortality. A Cohort Study Open
Background Severe pneumonia is a common cause of Intensive Care Unit (ICU) admissions. In critically ill patients, identification of the pathogen may allow timely adjustment of antibiotics and, therefore improve outcomes. The aim of this s…
View article: Decoding mpox: a systematic review and meta-analysis of the transmission and severity parameters of the 2022–2023 global outbreak
Decoding mpox: a systematic review and meta-analysis of the transmission and severity parameters of the 2022–2023 global outbreak Open
Introduction The 2022–2023 mpox outbreak has been the largest in history. We aim to synthesise the key epidemiological parameters related to the dynamics, transmission, and severity of mpox (incubation period, serial interval, generation t…
View article: COVID-19 mortality among solid organ transplant recipients and candidates before specific vaccine availability in Colombia
COVID-19 mortality among solid organ transplant recipients and candidates before specific vaccine availability in Colombia Open
Introduction: Coronavirus disease 2019 (COVID-19) is a life-threatening disease that was declared a pandemic in March 2020. Organ transplant recipients are vulnerable to infection and complications from COVID-19. The objective of this stud…
View article: Effect of Inappropriate Treatment in Hospitalized Patients with Pyelonephritis Treated with Cefuroxime: A Cohort Study
Effect of Inappropriate Treatment in Hospitalized Patients with Pyelonephritis Treated with Cefuroxime: A Cohort Study Open
The aim of this study was to evaluate the effect of inappropriate therapy in adult patients with community-acquired pyelonephritis caused by Escherichia coli receiving empirical treatment with cefuroxime during hospital stay and readmissio…
View article: Emergence of cryptic species and clades of <i>Meyerozyma guilliermondii</i> species complex exhibiting limited <i>in vitro</i> susceptibility to antifungals in patients with candidemia
Emergence of cryptic species and clades of <i>Meyerozyma guilliermondii</i> species complex exhibiting limited <i>in vitro</i> susceptibility to antifungals in patients with candidemia Open
Members of the Meyerozyma guilliermondii species complex are able to cause superficial and life-threatening systemic infections with low susceptibility to azoles and echinocandins. We tested 130 bloodstream M. guilliermondii complex isolat…
View article: Mortality Caused by Candida auris Bloodstream Infections in Comparison with Other Candida Species, a Multicentre Retrospective Cohort
Mortality Caused by Candida auris Bloodstream Infections in Comparison with Other Candida Species, a Multicentre Retrospective Cohort Open
Candida auris is an emerging pathogen considered to be critical in the World Health Organization fungal organisms list. The study aims to determine the mortality and hospital stays attributed to Candida auris (C. auris) compared to other C…
View article: Risk factors associated with acute kidney injury in a cohort of hospitalized patients with COVID-19
Risk factors associated with acute kidney injury in a cohort of hospitalized patients with COVID-19 Open
Background Patients with COVID-19 have a high incidence of acute kidney injury (AKI), which is associated with mortality. The objective of the study was to determine the factors associated with AKI in patients with COVID-19. Methodology A …
View article: Interventions to Improve Antibiotic Use in Hospitals with Different Levels of Complexity in Colombia: Findings from a Before-and-After Study and Suggestions for the Future
Interventions to Improve Antibiotic Use in Hospitals with Different Levels of Complexity in Colombia: Findings from a Before-and-After Study and Suggestions for the Future Open
Background: In the collaborative efforts to control bacterial antimicrobial resistance (AMR), the challenge for many low- and middle-income countries currently lies in the adequate design and successful implementation and operation of diff…
View article: Effect of bloodstream infection on survival in COVID-19 patients admitted to an intensive care unit in Colombia: a matched cohort analysis
Effect of bloodstream infection on survival in COVID-19 patients admitted to an intensive care unit in Colombia: a matched cohort analysis Open
BSI in patients with COVID-19 in ICU increases in-hospital mortality to 28 days. Other risk factors for mortality were IMV and age.