Jorgelina M. Calandria
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View article: <scp>ELV</scp> ‐ <scp>N34</scp> , <scp>RvD6</scp> ‐Isomer, or <scp>NPD1</scp> Halt Replication of <scp>SARS</scp> ‐ <scp>CoV</scp> ‐2 Omicron BA.5 Virus in Human Lung and Nasal Cells
<span>ELV</span> ‐ <span>N34</span> , <span>RvD6</span> ‐Isomer, or <span>NPD1</span> Halt Replication of <span>SARS</span> ‐ <span>CoV</span> ‐2 Omicron BA.5 Virus in Human Lung and Nasal Cells Open
Current vaccines rely on the sequence of Spike (S) protein to induce immunity against the severe acute respiratory coronavirus‐2 (SARS‐CoV‐2) virus. Because of the high mutation rate of the viral S protein, new mutant strains are developed…
View article: Elovanoid-N34 modulates TXNRD1 key in protection against oxidative stress-related diseases
Elovanoid-N34 modulates TXNRD1 key in protection against oxidative stress-related diseases Open
The thioredoxin (TXN) system is an NADPH + H + /FAD redox-triggered effector that sustains homeostasis, bioenergetics, detoxifying drug networks, and cell survival in oxidative stress-related diseases. Elovanoid (ELV)-N34 is an endogenousl…
View article: Elovanoid-N34 is a homeostatic switch that modulates TXNRD1 for cell survival
Elovanoid-N34 is a homeostatic switch that modulates TXNRD1 for cell survival Open
The thioredoxin (TRX) system is an NADP/FAD redox-triggered effector that sustains oxidative stress homeostatic environment, bioenergetics, and detoxifying drug networks. The bioactive lipid Elovanoid (ELV)-N34, derived from omega-3 fatty …
View article: Targeting Phospholipase D Pharmacologically Prevents Phagocytic Function Loss of Retinal Pigment Epithelium Cells Exposed to High Glucose Levels
Targeting Phospholipase D Pharmacologically Prevents Phagocytic Function Loss of Retinal Pigment Epithelium Cells Exposed to High Glucose Levels Open
We previously described the participation of canonical phospholipase D isoforms (PLD1 and PLD2) in the inflammatory response of retinal pigment epithelium (RPE) cells exposed to high glucose concentrations (HG). Here, we studied the role o…
View article: New Retinal Pigment Epithelial Cell Model to Unravel Neuroprotection Sensors of Neurodegeneration in Retinal Disease
New Retinal Pigment Epithelial Cell Model to Unravel Neuroprotection Sensors of Neurodegeneration in Retinal Disease Open
Retinal pigment epithelial (RPE) cells sustain photoreceptor integrity, and when this function is disrupted, retinal degenerations ensue. Herein, we characterize a new cell line from human RPE that we termed ABC . These cells remarkably re…
View article: cRel and Wnt5a/Frizzled 5 Receptor-Mediated Inflammatory Regulation Reveal Novel Neuroprotectin D1 Targets for Neuroprotection
cRel and Wnt5a/Frizzled 5 Receptor-Mediated Inflammatory Regulation Reveal Novel Neuroprotectin D1 Targets for Neuroprotection Open
Wnt5a triggers inflammatory responses and damage via NFkB/p65 in retinal pigment epithelial (RPE) cells undergoing uncompensated oxidative stress (UOS) and in experimental ischemic stroke. We found that Wnt5a-Clathrin-mediated uptake leads…
View article: AMPK modulation ameliorates dominant disease phenotypes of CTRP5 variant in retinal degeneration
AMPK modulation ameliorates dominant disease phenotypes of CTRP5 variant in retinal degeneration Open
Late-onset retinal degeneration (L-ORD) is an autosomal dominant disorder caused by a missense substitution in CTRP5 . Distinctive clinical features include sub-retinal pigment epithelium (RPE) deposits, choroidal neovascularization, and R…
View article: Elovanoids downregulate canonical SARS-CoV-2 cell-entry mediators and enhance protective signaling in human alveolar cells
Elovanoids downregulate canonical SARS-CoV-2 cell-entry mediators and enhance protective signaling in human alveolar cells Open
The pro-homeostatic lipid mediators elovanoids (ELVs) attenuate cell binding and entrance of the SARS-CoV-2 receptor-binding domain (RBD) in human primary alveoli cells in culture. We uncovered that very-long-chain polyunsaturated fatty ac…
View article: Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke
Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke Open
Ring finger protein 146 (Iduna) facilitates DNA repair and protects against cell death induced by NMDA receptor-mediated glutamate excitotoxicity or by cerebral ischemia. Neuroprotectin D1 (NPD1), a docosahexaenoic acid (DHA)-derived lipid…