Jörgen Isgaard
YOU?
Author Swipe
View article: Running in mice increases the expression of brain hemoglobin-related genes interacting with the GH/IGF-1 system
Running in mice increases the expression of brain hemoglobin-related genes interacting with the GH/IGF-1 system Open
The beneficial effects of exercise are partly mediated via local or systemic functions of the insulin-like growth factor-1 (IGF-1) system. As IGF-1 increases local brain hemoglobin beta (Hbb) transcripts, we hypothesized that exercise coul…
View article: Exercise and health-related quality of life and work-related outcomes in primary care patients with anxiety disorders – A randomized controlled study
Exercise and health-related quality of life and work-related outcomes in primary care patients with anxiety disorders – A randomized controlled study Open
HI Exercise improves HR-QoL and work ability in anxiety patients, especially when combined with antidepressants.
View article: A Nonlinear Relation between Body Mass Index and Long-Term Poststroke Functional Outcome—The Importance of Insulin Resistance, Inflammation, and Insulin-like Growth Factor-Binding Protein-1
A Nonlinear Relation between Body Mass Index and Long-Term Poststroke Functional Outcome—The Importance of Insulin Resistance, Inflammation, and Insulin-like Growth Factor-Binding Protein-1 Open
Both high serum insulin-like growth factor-binding protein-1 (s-IGFBP-1) and insulin resistance (IR) are associated with poor functional outcome poststroke, whereas overweight body mass index (BMI; 25–30) is related to fewer deaths and fav…
View article: Serum IGFBP-1 Concentration as a Predictor of Outcome after Ischemic Stroke—A Prospective Observational Study
Serum IGFBP-1 Concentration as a Predictor of Outcome after Ischemic Stroke—A Prospective Observational Study Open
Insulin-like growth factor-binding protein-1 (IGFBP-1) regulates insulin-like growth factor-I (IGF-I) bioactivity, and is a central player in normal growth, metabolism, and stroke recovery. However, the role of serum IGFBP-1 (s-IGFBP-1) af…
View article: Growth Hormone Increases BDNF and mTOR Expression in Specific Brain Regions after Photothrombotic Stroke in Mice
Growth Hormone Increases BDNF and mTOR Expression in Specific Brain Regions after Photothrombotic Stroke in Mice Open
Aims. We have shown that growth hormone (GH) treatment poststroke increases neuroplasticity in peri-infarct areas and the hippocampus, improving motor and cognitive outcomes. We aimed to explore the mechanisms of GH treatment by investigat…
View article: Circulating granulocyte colony-stimulating factor and functional outcome after ischemic stroke: an observational study
Circulating granulocyte colony-stimulating factor and functional outcome after ischemic stroke: an observational study Open
Objectives: While granulocyte colony-stimulating factor (G-CSF) has shown beneficial effects in experimental ischemic stroke (IS), these effects have not been reproduced clinically. Small-to-medium-sized observational studies have reported…
View article: Insulin-Like Growth Factor-II and Ischemic Stroke—A Prospective Observational Study
Insulin-Like Growth Factor-II and Ischemic Stroke—A Prospective Observational Study Open
Insulin-like growth factor-II (IGF-II) regulates prenatal brain development, but the role in adult brain function and injury is unclear. Here, we determined whether serum levels of IGF-II (s-IGF-II) are associated with mortality and functi…
View article: Myocardial expression of somatotropic axis, adrenergic signalling, and calcium handling genes in heart failure with preserved ejection fraction and heart failure with reduced ejection fraction
Myocardial expression of somatotropic axis, adrenergic signalling, and calcium handling genes in heart failure with preserved ejection fraction and heart failure with reduced ejection fraction Open
Aims Limited data are available regarding cardiac expression of molecules involved in heart failure (HF) pathophysiology. The majority of the studies have focused on end‐stage HF with reduced ejection fraction (HFrEF) without comparison wi…
View article: Growth Hormone and Neuronal Hemoglobin in the Brain—Roles in Neuroprotection and Neurodegenerative Diseases
Growth Hormone and Neuronal Hemoglobin in the Brain—Roles in Neuroprotection and Neurodegenerative Diseases Open
In recent years, evidence for hemoglobin (Hb) synthesis in both animal and human brains has been accumulating. While circulating Hb originating from cerebral hemorrhage or other conditions is toxic, there is also substantial production of …
View article: Metabolic Effects of Cortisone Acetate vs Hydrocortisone in Patients With Secondary Adrenal Insufficiency
Metabolic Effects of Cortisone Acetate vs Hydrocortisone in Patients With Secondary Adrenal Insufficiency Open
Context Pharmacokinetic properties of cortisone acetate (CA) and hydrocortisone (HC) differ because CA needs to be converted into cortisol to become active. Objective This work analyzed the metabolic consequences of switching CA to an equi…
View article: Growth Hormone Treatment Promotes Remote Hippocampal Plasticity after Experimental Cortical Stroke
Growth Hormone Treatment Promotes Remote Hippocampal Plasticity after Experimental Cortical Stroke Open
Cognitive impairment is common after stroke, and disturbances in hippocampal function are often involved, even in remote non-hippocampal injuries. In terms of hippocampal function, growth hormone (GH) is known to affects plasticity and cog…
View article: Relationship between Levels of Pre-Stroke Physical Activity and Post-Stroke Serum Insulin-Like Growth Factor I
Relationship between Levels of Pre-Stroke Physical Activity and Post-Stroke Serum Insulin-Like Growth Factor I Open
Physical activity (PA) and insulin-like growth factor I (IGF-I) have beneficial effects for patients who have suffered an ischemic stroke (stroke). However, the relationship between the levels of PA and IGF-I after stroke has not been expl…
View article: Growth Hormone Promotes Motor Function after Experimental Stroke and Enhances Recovery-Promoting Mechanisms within the Peri-Infarct Area
Growth Hormone Promotes Motor Function after Experimental Stroke and Enhances Recovery-Promoting Mechanisms within the Peri-Infarct Area Open
Motor impairment is the most common and widely recognised clinical outcome after stroke. Current clinical practice in stroke rehabilitation focuses mainly on physical therapy, with no pharmacological intervention approved to facilitate fun…
View article: Circulating levels of vascular endothelial growth factor and post‐stroke long‐term functional outcome
Circulating levels of vascular endothelial growth factor and post‐stroke long‐term functional outcome Open
High 3-month s-VEGF is independently associated with poor 2-year functional outcome but not with 3-month outcome.
View article: Association Between Levels of Serum Insulin-like Growth Factor I and Functional Recovery, Mortality, and Recurrent Stroke at a 7-year Follow-up
Association Between Levels of Serum Insulin-like Growth Factor I and Functional Recovery, Mortality, and Recurrent Stroke at a 7-year Follow-up Open
Background The association of serum insulin-like growth factor I (s-IGF-I) with favorable outcome after ischemic stroke (IS) beyond 2 years is unknown. We investigated whether the levels of s-IGF-I 3 months post-stroke were associated with…
View article: Growth Hormone Deficiency Is Frequent After Recent Stroke
Growth Hormone Deficiency Is Frequent After Recent Stroke Open
Introduction: The incidence of pituitary dysfunction after severe ischemic stroke is unknown, however given the increasing attention to pituitary dysfunction after neurological injuries such as traumatic brain injury, this may represent a …
View article: Growth Hormone Improves Cognitive Function After Experimental Stroke
Growth Hormone Improves Cognitive Function After Experimental Stroke Open
Background and Purpose— Cognitive impairment is a common outcome for stroke survivors. Growth hormone (GH) could represent a potential therapeutic option as this peptide hormone has been shown to improve cognition in various clinical condi…
View article: Mode of GH administration and gene expression in the female rat brain
Mode of GH administration and gene expression in the female rat brain Open
The endogenous secretion of growth hormone (GH) is sexually dimorphic in rats with females having a more even and males a more pulsatile secretion and low trough levels. The mode of GH administration, mimicking the sexually dimorphic secre…
View article: Growth Hormone Deficiency Is Associated with Worse Cardiac Function, Physical Performance, and Outcome in Chronic Heart Failure: Insights from the T.O.S.CA. GHD Study
Growth Hormone Deficiency Is Associated with Worse Cardiac Function, Physical Performance, and Outcome in Chronic Heart Failure: Insights from the T.O.S.CA. GHD Study Open
GH deficiency identifies a subgroup of CHF patients characterized by impaired functional capacity, LV remodeling and elevated NT-proBNP levels. GHD is also associated with increased all-cause mortality.
View article: Low Circulating Acute Brain-Derived Neurotrophic Factor Levels Are Associated With Poor Long-Term Functional Outcome After Ischemic Stroke
Low Circulating Acute Brain-Derived Neurotrophic Factor Levels Are Associated With Poor Long-Term Functional Outcome After Ischemic Stroke Open
Background and Purpose— Brain-derived neurotrophic factor (BDNF) plays important roles in brain plasticity and repair, and it influences stroke outcomes in animal models. Circulating BDNF concentrations are lowered in patients with traumat…
View article: Growth hormone increases ALAS2, the rate-limiting enzyme of Hbb in male rat hippocampus
Growth hormone increases ALAS2, the rate-limiting enzyme of Hbb in male rat hippocampus Open
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
View article: Welcome to Biomedicine Hub
Welcome to Biomedicine Hub Open
We are extremely excited and passionate about our new journal Biomedicine Hub . Why?
\nSimply consider how many times you have seen the phrase ‘interdisciplinary cooperation is
\nrequired’. This phrase is often used as an almost cliché sig…
View article: Serum erythropoietin and outcome after ischaemic stroke: a prospective study
Serum erythropoietin and outcome after ischaemic stroke: a prospective study Open
Objectives Erythropoietin (EPO), which is inversely associated with blood haemoglobin (Hb), exerts neuroprotective effects in experimental ischaemic stroke (IS). However, clinical treatment trials have so far been negative. Here, in patien…
View article: The T.O.S.CA. Project: Research, Education and Care
The T.O.S.CA. Project: Research, Education and Care Open
Despite recent and exponential improvements in diagnostic- therapeutic pathways, an existing “GAP†has been revealed between the “real world care†and the “optimal care†of patients with chronic heart failure (CHF). We present …