Joris Hoeks
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View article: The association between clock gene polymorphisms and type 2 diabetes: A systematic review and meta-analysis
The association between clock gene polymorphisms and type 2 diabetes: A systematic review and meta-analysis Open
Specific polymorphisms in circadian genes, including CRY2, MTNR1B, CLOCK, and PER3, were associated with glycemic parameters and type 2 diabetes risk. These associations may be influenced by lifestyle and environmental factors, and interve…
View article: Effect of timed exercise interventions on patient-reported outcome measures: A systematic review
Effect of timed exercise interventions on patient-reported outcome measures: A systematic review Open
Background Exercising at a specific time of day has the potential to mitigate the negative effects of disrupted circadian rhythms caused by irregular work and sleep schedules on the development of chronic diseases. Afternoon/evening exerci…
View article: Delayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle
Delayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle Open
Exercise is fundamental to healthy aging, yet the degree to which it mitigates age-related molecular changes and how varying physical fitness levels influence the molecular response to exercise with age remain unclear. To address this, we …
View article: Amount and timing of physical activity in relation to sleep quality in the general middle-aged Dutch population: A cross-sectional analysis
Amount and timing of physical activity in relation to sleep quality in the general middle-aged Dutch population: A cross-sectional analysis Open
Differences in sleep quality are unlikely to be biological mechanisms underlying the previously shown associations between timing of physical activity and metabolic health.
View article: Cold acclimation with shivering improves metabolic health in adults with overweight or obesity
Cold acclimation with shivering improves metabolic health in adults with overweight or obesity Open
View article: The effect of altered sleep timing on glycaemic outcomes: Systematic review of human intervention studies
The effect of altered sleep timing on glycaemic outcomes: Systematic review of human intervention studies Open
Aims Alterations in sleep timing can lead to disturbances in glycaemic control, although the evidence is inconsistent. Therefore, this systematic review summarizes results from human intervention studies of altered sleep timing on glycaemi…
View article: Plasma triacylglycerol length and saturation level mark healthy aging groups in humans
Plasma triacylglycerol length and saturation level mark healthy aging groups in humans Open
View article: Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T
Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T Open
NADH and NAD+ act as electron donors and acceptors and NAD+ was shown to stimulate mitochondrial biogenesis and metabolic health. We here develop a non-invasive Phosphorous Magnetic Resonance Spectroscopy (31
View article: Plasma triacylglycerol length and saturation level mark healthy aging groups in humans
Plasma triacylglycerol length and saturation level mark healthy aging groups in humans Open
Complex lipids, essential components in biological processes, exhibit conserved age-related changes that alter membrane properties, cellular functions, and are implicated as biomarkers and contributors to longevity and age-related diseases…
View article: The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis
The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis Open
Our results demonstrate that ATR-127 is a highly effective, novel β2- and β3-ARs agonist holding great therapeutic promise for the treatment of obesity and its comorbidities, whilst potentially limiting cardiovascular complications. As suc…
View article: A conserved complex lipid signature marks human muscle aging and responds to short-term exercise
A conserved complex lipid signature marks human muscle aging and responds to short-term exercise Open
View article: The effect of preprandial versus postprandial physical activity on glycaemia: Meta-analysis of human intervention studies
The effect of preprandial versus postprandial physical activity on glycaemia: Meta-analysis of human intervention studies Open
This meta-analysis aims to investigate the effect of preprandial physical activity (PA) versus postprandial PA on glycaemia in human intervention studies. Medline and Embase.com were searched until February 2023 for intervention studies in…
View article: Exercise training modifies skeletal muscle clock gene expression but not 24‐hour rhythmicity in substrate metabolism of men with insulin resistance
Exercise training modifies skeletal muscle clock gene expression but not 24‐hour rhythmicity in substrate metabolism of men with insulin resistance Open
Twenty‐four hour rhythmicity in whole‐body substrate metabolism, skeletal muscle clock gene expression and mitochondrial respiration is compromised upon insulin resistance. With exercise training known to ameliorate insulin resistance, our…
View article: The impact of prolonged fasting on 24h energy metabolism and its 24h rhythmicity in healthy, lean males: A randomized cross-over trial
The impact of prolonged fasting on 24h energy metabolism and its 24h rhythmicity in healthy, lean males: A randomized cross-over trial Open
View article: SIRT3 overexpression in rat muscle does not ameliorate peripheral insulin resistance
SIRT3 overexpression in rat muscle does not ameliorate peripheral insulin resistance Open
Reduced expression of the NAD + -dependent deacetylase, SIRT3, has been associated with insulin resistance and metabolic dysfunction in humans and rodents. In this study, we investigated whether specific overexpression of SIRT3 in vivo in …
View article: Invasive and noninvasive markers of human skeletal muscle mitochondrial function
Invasive and noninvasive markers of human skeletal muscle mitochondrial function Open
Mitochondria are organelles that fuel cellular energy requirements by ATP formation via aerobic metabolism. Given the wide variety of methods to assess skeletal muscle mitochondrial capacity, we tested how well different invasive and nonin…
View article: A metabolomic signature of decelerated physiological aging in human plasma
A metabolomic signature of decelerated physiological aging in human plasma Open
View article: PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans
PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans Open
View article: Twenty-four hour rhythmicity in mitochondrial network connectivity and mitochondrial respiration; a study in human skeletal muscle biopsies of young lean and older individuals with obesity
Twenty-four hour rhythmicity in mitochondrial network connectivity and mitochondrial respiration; a study in human skeletal muscle biopsies of young lean and older individuals with obesity Open
View article: Physiological and molecular mechanisms of cold-induced improvements in glucose homeostasis in humans beyond brown adipose tissue
Physiological and molecular mechanisms of cold-induced improvements in glucose homeostasis in humans beyond brown adipose tissue Open
Exposure to low ambient temperatures has previously been demonstrated to markedly improve glucose homeostasis in both rodents and humans. Although the brown adipose tissue is key in mediating these beneficial effects in rodents, its contri…
View article: Effect of β2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial
Effect of β2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial Open
β 2 -agonist treatment improves skeletal muscle glucose uptake and whole-body glucose homeostasis in rodents, likely via mTORC2-mediated signalling. However, human data on this topic is virtually absent. We here investigate the effects of …
View article: Divergent remodeling of the skeletal muscle metabolome over 24 h between young, healthy men and older, metabolically compromised men
Divergent remodeling of the skeletal muscle metabolome over 24 h between young, healthy men and older, metabolically compromised men Open
View article: Skeletal muscle mitochondrial inertia is associated with carnitine acetyltransferase activity and physical function in humans
Skeletal muscle mitochondrial inertia is associated with carnitine acetyltransferase activity and physical function in humans Open
BACKGROUNDAt the onset of exercise, the speed at which phosphocreatine (PCr) decreases toward a new steady state (PCr on-kinetics) reflects the readiness to activate mitochondrial ATP synthesis, which is secondary to Acetyl-CoA availabilit…
View article: Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism
Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism Open
View article: NAD+ to assess health in aging humans
NAD+ to assess health in aging humans Open
The molecular changes that occur in aging cells prime the organism for age-related disease. One of the changes that occur with age, extensively documented in mice, is the decline of nicotinamide adenine dinucleotide (NAD +) [1]. Discovered…
View article: Three weeks of time-restricted eating improves glucose homeostasis in adults with type 2 diabetes but does not improve insulin sensitivity: a randomised crossover trial
Three weeks of time-restricted eating improves glucose homeostasis in adults with type 2 diabetes but does not improve insulin sensitivity: a randomised crossover trial Open
View article: A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes
A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes Open
View article: Erratum. Effects of the SGLT2 Inhibitor Dapagliflozin on Energy Metabolism in Patients With Type 2 Diabetes: A Randomized, Double-Blind Crossover Trial. Diabetes Care 2021;44:1334–1343
Erratum. Effects of the SGLT2 Inhibitor Dapagliflozin on Energy Metabolism in Patients With Type 2 Diabetes: A Randomized, Double-Blind Crossover Trial. Diabetes Care 2021;44:1334–1343 Open
View article: Healthy aging and muscle function are positively associated with NAD+ abundance in humans
Healthy aging and muscle function are positively associated with NAD+ abundance in humans Open
View article: The influence of bright and dim light on substrate metabolism, energy expenditure and thermoregulation in insulin-resistant individuals depends on time of day
The influence of bright and dim light on substrate metabolism, energy expenditure and thermoregulation in insulin-resistant individuals depends on time of day Open