Jormay Lim
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View article: Multiplexed, scalable analog recording of gene regulation dynamics over weeks using intracellular protein tapes
Multiplexed, scalable analog recording of gene regulation dynamics over weeks using intracellular protein tapes Open
Gene expression is constantly regulated by gene regulatory networks that consist of multiple regulatory components to mediate cellular functions. An ideal tool for analyzing gene regulation processes would provide simultaneous measurements…
View article: ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain
ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain Open
Accumulating evidence has shown transcranial low-intensity ultrasound can be potentially a non-invasive neural modulation tool to treat brain diseases. However, the underlying mechanism remains elusive and the majority of studies on animal…
View article: Author response: ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain
Author response: ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Accumulating evidence has shown…
View article: Low intensity ultrasound enhances cisplatin uptake <i>in vitro</i> by cochlear hair cells
Low intensity ultrasound enhances cisplatin uptake <i>in vitro</i> by cochlear hair cells Open
Drug delivery to the inner ear has been challenging due to the blood-labyrinth barrier. Intracochlear drug delivery is an invasive alternative with less pharmacokinetic variables. In this study, the effect of low intensity ultrasound on dr…
View article: Editorial: Phosphorylation-Dependent Peptidyl-Prolyl Cis/Trans Isomerase PIN1
Editorial: Phosphorylation-Dependent Peptidyl-Prolyl Cis/Trans Isomerase PIN1 Open
EDITORIAL article Front. Cell Dev. Biol., 27 November 2020 | https://doi.org/10.3389/fcell.2020.620418
View article: The responses of nucleus pulposus cells to pressure and ultrasound stimulation
The responses of nucleus pulposus cells to pressure and ultrasound stimulation Open
A cellular stimulation device with a pressurized chamber is developed to investigate the effect of ultrasound and pressure fluctuation on nucleus pulposus (NP) cells. The pressurized chamber is designed to emulate the in vivo environment o…
View article: ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain
ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain Open
Accumulating evidence has shown transcranial low-intensity ultrasound can be potentially a non-invasive neural modulation tool to treat brain diseases. However, the underlying mechanism remains elusive, because the majority of studies on a…
View article: Piezoelectric stimulation by ultrasound facilitates chondrogenesis of mesenchymal stem cells
Piezoelectric stimulation by ultrasound facilitates chondrogenesis of mesenchymal stem cells Open
A cellular stimulation device utilizing an AT-cut quartz coverslip mounted on an ultrasonic live imaging chamber is developed to investigate the effect of piezoelectric stimulation. Two types of chambers deliver ultrasound at intensities r…
View article: Design of an ultrasound chamber for cellular excitation and observation
Design of an ultrasound chamber for cellular excitation and observation Open
In this work, a design of integrating ultrasonic transduction with live cell imaging chamber is introduced. The principle of a metal-incident-glass-output acoustic path was used to deliver a uniform energy profile into the imaging/incubati…
View article: Regulator of G Protein Signaling Protein 12 (Rgs12) Controls Mouse Osteoblast Differentiation via Calcium Channel/Oscillation and Gαi-ERK Signaling
Regulator of G Protein Signaling Protein 12 (Rgs12) Controls Mouse Osteoblast Differentiation via Calcium Channel/Oscillation and Gαi-ERK Signaling Open
Bone homeostasis intimately relies on the balance between osteoblasts (OBs) and osteoclasts (OCs). Our previous studies have revealed that regulator of G protein signaling protein 12 (Rgs12), the largest protein in the Rgs super family, is…