Jörn Dengjel
YOU?
Author Swipe
View article: POLYamine treatment in elderly patients with Coronary Artery Disease (POLYCAD): study protocol for a Danish randomised, double-blind, placebo-controlled trial of spermidine treatment versus placebo
POLYamine treatment in elderly patients with Coronary Artery Disease (POLYCAD): study protocol for a Danish randomised, double-blind, placebo-controlled trial of spermidine treatment versus placebo Open
ClinicalTrials.gov identifier NCT06186102 (first posted 12 June 2023). Participant enrolment began on 4 January 2024, and trial completion is anticipated in August 2026.
View article: Defective chaperone-mediated autophagy in the retinal pigment epithelium of age-related macular degeneration patients
Defective chaperone-mediated autophagy in the retinal pigment epithelium of age-related macular degeneration patients Open
Autophagy is one of the main intracellular recycling systems and its impairment is considered a primary hallmark of the aging process. Defective macroautophagy in the retinal pigment epithelium (RPE) has been described in age-related macul…
View article: Decorin Evokes a Pro‐Lysosomal Pathway in Lymphatic Endothelial Cells
Decorin Evokes a Pro‐Lysosomal Pathway in Lymphatic Endothelial Cells Open
The lymphatic system is critical to the body's immune and circulatory system, and lymphangiogenesis, the development of new lymphatic vessels from pre‐existing ones, is a significant process capitalized upon by cancer during tumorigenesis.…
View article: Exploration of the proxiOME of large subunit ribosomal proteins reveals Acl1 and Bcl1 as cooperating dedicated chaperones of Rpl1
Exploration of the proxiOME of large subunit ribosomal proteins reveals Acl1 and Bcl1 as cooperating dedicated chaperones of Rpl1 Open
The eukaryotic ribosome consists of four ribosomal RNAs (rRNAs) and around 80 ribosomal proteins (r-proteins). Most r-proteins, due to their extensive interactions with rRNA, contain highly basic regions, which can predispose them to aggre…
View article: A novel accessory gene product of tick-borne Dhori-Orthomyxovirus, encoded by overlooked spliced transcripts of RNA segment 6
A novel accessory gene product of tick-borne Dhori-Orthomyxovirus, encoded by overlooked spliced transcripts of RNA segment 6 Open
Dhori virus (DHOV) ( Orthomyxoviridae, genus: Thogotovirus) is a tick-borne virus with a segmented, negative-sense RNA genome. Thogotoviruses can be divided into two clades, Thogoto-like and Dhori-like viruses, which differ in their coding…
View article: MIRO2-mediated mitochondrial transfer from cancer cells induces cancer-associated fibroblast differentiation
MIRO2-mediated mitochondrial transfer from cancer cells induces cancer-associated fibroblast differentiation Open
Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment that commonly support cancer development and progression. Here we show that different cancer cells transfer mitochondria to fibroblasts in cocultures and…
View article: Isolation of bacterial extracellular vesicles from raw samples using a portable microstructured electrochemical device
Isolation of bacterial extracellular vesicles from raw samples using a portable microstructured electrochemical device Open
Bacterial extracellular vesicles (EVs) are nanosized vesicles released by both Gram-negative and Gram-positive bacteria, playing critical roles in microbial communication, host-pathogen interactions, and immune modulation. Despite their si…
View article: O-mannosylation and protein maturation check-points represent therapeutic opportunities in BRAF fusion protein oncogenesis
O-mannosylation and protein maturation check-points represent therapeutic opportunities in BRAF fusion protein oncogenesis Open
Fusions between protein-coding genes are common oncogenic drivers across cancers, typically pairing a proto-oncogene with partner that does not independently drive cancer. In all therapeutically actionable fusions, the proto-oncogene is th…
View article: Quantification of SnRK1.1 response through analysis of its intracellular distribution
Quantification of SnRK1.1 response through analysis of its intracellular distribution Open
Maintaining energy homeostasis is a major challenge for plants facing changes in growth conditions. The Sucrose non-Fermenting 1 (SNF1) Related Kinase 1 (SnRK1) complex is a central player in securing cell energy homeostasis. The α-subunit…
View article: Interaction with AK2A links AIFM1 to cellular energy metabolism
Interaction with AK2A links AIFM1 to cellular energy metabolism Open
Apoptosis-inducing factor 1 (AIFM1) is a flavoprotein essential for mitochondrial function and biogenesis. Its interaction with MIA40/CHCHD4, the central component of the mitochondrial disulfide relay, accounts for some, but not all, aspec…
View article: Combination of in vivo and in vitro phosphoproteomics determines the PP2A target repertoire on proteome scale
Combination of in vivo and in vitro phosphoproteomics determines the PP2A target repertoire on proteome scale Open
Dynamics of protein phosphorylation are regulated by the interplay of kinases and phosphatases. Current mass spectrometry-based phosphoproteomic approaches are extremely powerful in identifying and quantifying tens of thousands of phosphos…
View article: The Developing Retina Undergoes Mitochondrial Remodeling via PINK1/PRKN-dependent Mitophagy
The Developing Retina Undergoes Mitochondrial Remodeling via PINK1/PRKN-dependent Mitophagy Open
Mitophagy, the selective degradation of mitochondria, is essential for retinal ganglion cell (RGC) differentiation and retinal homeostasis. However, the specific mitophagy pathways involved and their temporal dynamics during retinal develo…
View article: TORC1 autonomously controls its spatial partitioning via the Rag GTPase tether Tco89
TORC1 autonomously controls its spatial partitioning via the Rag GTPase tether Tco89 Open
The eukaryotic target of rapamycin complex 1 (TORC1) kinase is a homeostatic regulator of growth, integrating nutritional cues at the endolysosomal compartment. Amino acids activate mammalian TORC1 (mTORC1) through the Rag GTPases that rec…
View article: Antagonist actions of CMK-1/CaMKI and TAX-6/calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli
Antagonist actions of CMK-1/CaMKI and TAX-6/calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli Open
Thermal nociception in Caenorhabditis elegans is regulated by the Ca² + /calmodulin-dependent protein kinase CMK-1, but its downstream effectors have remained unclear. Here, we combined in vitro kinase assays with mass-spectrometry-based p…
View article: Author response: Antagonist actions of CMK-1/CaMKI and TAX-6/calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli
Author response: Antagonist actions of CMK-1/CaMKI and TAX-6/calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli Open
View article: Mitotic phosphorylation of Lamin B1 rod domain by ULK1 and Aurora A/PLK1 promotes spindle function
Mitotic phosphorylation of Lamin B1 rod domain by ULK1 and Aurora A/PLK1 promotes spindle function Open
The coil-coil rod domain mediating the lateral assembly of lamin filaments has been reported to undergo phosphorylation by proteomic approaches, but the functional implications of these modifications are currently unknown. Here, we report …
View article: A new method to quantify the spatiotemporal localization of SnRK1.1
A new method to quantify the spatiotemporal localization of SnRK1.1 Open
Maintaining energy homeostasis is a major challenge for plants in the current context of climate change. The Sucrose-non fermenting 1 (SNF1)-related kinase 1 (SnRK1) complex, a member of the SNF1-AMP-activated protein kinase (AMPK)-SnRK1 f…
View article: Antagonist actions of CMK-1/CaMKI and TAX-6/Calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli
Antagonist actions of CMK-1/CaMKI and TAX-6/Calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli Open
Response decrease following repeated exposure to innocuous or noxious stimuli is a conserved adaptation phenomenon often referred to as habituation. Impaired nociceptive habituation is associated with several pain conditions in human, but …
View article: Author response: Antagonist actions of CMK-1/CaMKI and TAX-6/Calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli
Author response: Antagonist actions of CMK-1/CaMKI and TAX-6/Calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli Open
View article: The developing retina undergoes mitochondrial remodeling via PINK1/PRKN-dependent mitophagy
The developing retina undergoes mitochondrial remodeling via PINK1/PRKN-dependent mitophagy Open
Mitophagy, the selective degradation of mitochondria, is essential for retinal ganglion cell (RGC) differentiation and retinal homeostasis. However, the specific mitophagy pathways involved and their temporal dynamics during retinal develo…
View article: Antagonist actions of CMK-1/CaMKI and TAX-6/calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli
Antagonist actions of CMK-1/CaMKI and TAX-6/calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli Open
Thermal nociception in Caenorhabditis elegans is regulated by the Ca² + /calmodulin-dependent protein kinase CMK-1, but its downstream effectors have remained unclear. Here, we combined in vitro kinase assays with mass-spectrometry-based p…
View article: Antagonist actions of CMK-1/CaMKI and TAX-6/Calcineurin along the C. elegans thermal avoidance circuit orchestrate nociceptive habituation
Antagonist actions of CMK-1/CaMKI and TAX-6/Calcineurin along the C. elegans thermal avoidance circuit orchestrate nociceptive habituation Open
Habituation is a conserved physiological phenomenon, during which responses decrease following repeated exposure to innocuous or noxious stimuli. Impaired nociceptive habituation is associated with several pain conditions in human, but the…
View article: Author response: Antagonist actions of CMK-1/CaMKI and TAX-6/Calcineurin along the C. elegans thermal avoidance circuit orchestrate nociceptive habituation
Author response: Antagonist actions of CMK-1/CaMKI and TAX-6/Calcineurin along the C. elegans thermal avoidance circuit orchestrate nociceptive habituation Open
View article: Multi-omics analysis of keratinocytes reveals dermokine-dependent regulation of cell-cell adhesion via p120
Multi-omics analysis of keratinocytes reveals dermokine-dependent regulation of cell-cell adhesion via p120 Open
Summary Loss of keratinocyte differentiation is a leading cause in several skin diseases and needs to be controlled in adult homeostasis by for instance growth factors and proteases. Among them, we studied the role of isoform-rich dermokin…
View article: Hypoxia-induced conversion of sensory Schwann cells into repair cells is regulated by HDAC8
Hypoxia-induced conversion of sensory Schwann cells into repair cells is regulated by HDAC8 Open
After a peripheral nerve injury, Schwann cells (SCs), the myelinating glia of the peripheral nervous system, convert into repair cells that foster axonal regrowth, and then remyelinate or re-ensheath regenerated axons, thereby ensuring fun…
View article: A New Method to Quantify the Spatiotemporal Localization of Snrk1.1
A New Method to Quantify the Spatiotemporal Localization of Snrk1.1 Open
View article: Interactors and neighbors of ULK1 complex members
Interactors and neighbors of ULK1 complex members Open
The ULK1 kinase complex plays a crucial role in autophagosome biogenesis. To identify interactors or regulators of ULK1 complex assembly influencing autophagosome biogenesis, we performed an interaction proteomics screen. Employing both af…
View article: Targeted proteomics addresses selectivity and complexity of protein degradation by autophagy
Targeted proteomics addresses selectivity and complexity of protein degradation by autophagy Open
Macroautophagy/autophagy is a constitutively active catabolic lysosomal degradation pathway, often found dysregulated in human diseases. It is often considered to act in a cytoprotective manner and is commonly upregulated in cells undergoi…
View article: The mTOR pathway controls phosphorylation of BRAF at T401
The mTOR pathway controls phosphorylation of BRAF at T401 Open
BRAF serves as a gatekeeper of the RAS/RAF/MEK/ERK pathway, which plays a crucial role in homeostasis. Since aberrant signalling of this axis contributes to cancer and other diseases, it is tightly regulated by crosstalk with the PI3K/AKT/…
View article: Selective autophagy of ribosomes balances a tradeoff between starvation survival and growth resumption
Selective autophagy of ribosomes balances a tradeoff between starvation survival and growth resumption Open
In environments with fluctuating nutrient abundance, organisms must survive periods of starvation, yet quickly resume growth upon food encounter. A tradeoff between these objectives is well-documented in microbes, where it is caused by the…