José Augusto Sgarbi
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View article: Thyroid antibody status, thyroid function, and the risk of coronary heart disease and stroke: an individual participant data analysis from 14 cohorts
Thyroid antibody status, thyroid function, and the risk of coronary heart disease and stroke: an individual participant data analysis from 14 cohorts Open
Objective The association of thyroid peroxidase antibodies (TPOAb) status with cardiovascular disease (CVD) risk, independent of thyroid function, remains unclear. We aimed to determine whether positive TPOAb is associated with increased C…
View article: The Metabolic Vulnerability Index (MVX) in Subclinical Thyroid Disorders and Euthyroidism: A Cross-Sectional Exploratory Analysis from the ELSA-Brasil Study
The Metabolic Vulnerability Index (MVX) in Subclinical Thyroid Disorders and Euthyroidism: A Cross-Sectional Exploratory Analysis from the ELSA-Brasil Study Open
Background: Recently, a new biomarker index that reflects inflammation and protein energy malnutrition has emerged as a predictor of mortality in cardiovascular diseases. The metabolic vulnerability index (MVX) derives from blood-based inf…
View article: Associations Between Subclinical Thyroid Dysfunction and Cardiovascular Risk Factors According to Age and Sex
Associations Between Subclinical Thyroid Dysfunction and Cardiovascular Risk Factors According to Age and Sex Open
Context Subclinical thyroid dysfunction (ScTD), comprising subclinical hypothyroidism (SHypo) and subclinical hyperthyroidism (SHyper), has been associated with increased risk for cardiovascular events. Objective To assess associations bet…
View article: Branched-Chain Amino Acids, Alanine, and Thyroid Function: A Cross-Sectional, Nuclear Magnetic Resonance (NMR)-Based Approach from ELSA-Brasil
Branched-Chain Amino Acids, Alanine, and Thyroid Function: A Cross-Sectional, Nuclear Magnetic Resonance (NMR)-Based Approach from ELSA-Brasil Open
The association of thyroid function with essential and non-essential amino acids is understudied, despite their common metabolic roles. Thus, our aim was to evaluate the association of thyroid function with the levels of branched-chain ami…
View article: Associations of TSH, free T3, free T4, and conversion ratio with incident hypertension: results from the prospective Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
Associations of TSH, free T3, free T4, and conversion ratio with incident hypertension: results from the prospective Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) Open
Low FT4 levels may be a mild risk factor for incident hypertension in euthyroid individuals and persons with subclinical thyroid dysfunction.
View article: Editorial: The thyroid and Covid-19, volume II
Editorial: The thyroid and Covid-19, volume II Open
EDITORIAL article Front. Endocrinol., 27 November 2023Sec. Thyroid Endocrinology Volume 14 - 2023 | https://doi.org/10.3389/fendo.2023.1331452
View article: Potential Determinants of Thyroid Peroxidase Antibodies and Mortality Risk: Results From the ELSA-Brasil Study
Potential Determinants of Thyroid Peroxidase Antibodies and Mortality Risk: Results From the ELSA-Brasil Study Open
Context The presence of thyroid peroxidase antibodies (TPOAbs) may be considered as an indicator of adverse health outcomes. Objective We aimed to investigate the potential determinants of TPOAb levels and to analyze the association betwee…
View article: The optimal healthy ranges of thyroid function defined by the risk of cardiovascular disease and mortality: systematic review and individual participant data meta-analysis
The optimal healthy ranges of thyroid function defined by the risk of cardiovascular disease and mortality: systematic review and individual participant data meta-analysis Open
BACKGROUND Reference intervals of thyroid-stimulating hormone (TSH) and free thyroxine (FT4) are statistically defined by the 2·5-97·5th percentiles, without accounting for potential risk of clinical outcomes. We aimed to define the optima…
View article: The Relationship between Type 1 Diabetes Mellitus, TNF-α, and IL-10 Gene Expression
The Relationship between Type 1 Diabetes Mellitus, TNF-α, and IL-10 Gene Expression Open
Type 1 diabetes mellitus (T1DM) is one of the major chronic diseases in children worldwide. This study aimed to investigate interleukin-10 (IL-10) gene expression and tumor necrosis factor-alpha (TNF-α) in T1DM. A total of 107 patients wer…
View article: Editorial: New insights in thyroid and Covid-19
Editorial: New insights in thyroid and Covid-19 Open
EDITORIAL article Front. Endocrinol., 23 December 2022Sec. Thyroid Endocrinology Volume 13 - 2022 | https://doi.org/10.3389/fendo.2022.1112695
View article: Thyroid-Stimulating Hormone and Thyroid Hormones and Incidence of Diabetes: Prospective Results of the Brazilian Longitudinal Study of Adult Health (ELSA-BRASIL)
Thyroid-Stimulating Hormone and Thyroid Hormones and Incidence of Diabetes: Prospective Results of the Brazilian Longitudinal Study of Adult Health (ELSA-BRASIL) Open
Background: There are conflicting data regarding the association of thyroid function with incident diabetes. We prospectively investigated thyrotropin (TSH), free thyroxine (fT4), free triiodothyronine (fT3), and its conversion ratio (fT3:…
View article: Incorporating Baseline Outcome Data in Individual Participant Data Meta-Analysis of Non-randomized Studies
Incorporating Baseline Outcome Data in Individual Participant Data Meta-Analysis of Non-randomized Studies Open
Background In non-randomized studies (NRSs) where a continuous outcome variable (e.g., depressive symptoms) is assessed at baseline and follow-up, it is common to observe imbalance of the baseline values between the treatment/exposure grou…
View article: Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil
Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil Open
The high-risk group selected mostly women, older, lower-income/education, higher BMI, waist circumference, and of hypertension, diabetes, depression, and higher levels of GlycA when compared to the ACS. The strategy chosen to define the hi…
View article: Approach to adult patients with primary hypothyroidism in some special situations: a position statement from the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism (SBEM)
Approach to adult patients with primary hypothyroidism in some special situations: a position statement from the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism (SBEM) Open
Primary hypothyroidism is a common disorder in clinical practice. The management of most cases of hypothyroidism is usually straightforward, but the best approach in some special situations may raise questions among physicians. This positi…
View article: Incidence of TPOAb over a 4-year follow-up period: results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
Incidence of TPOAb over a 4-year follow-up period: results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) Open
Based on the results of this study, the incidence of TPOAb per year and at a 4-year follow-up period are compatible with those of a country with adequate iodine intake.
View article: Management of thyroid disorders during the COVID-19 outbreak: a position statement from the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism (SBEM)
Management of thyroid disorders during the COVID-19 outbreak: a position statement from the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism (SBEM) Open
This position statement was prepared to guide endocrinologists on the best approach to managing thyroid disorders during the coronavirus disease (COVID-19) pandemic. The most frequent thyroid hormonal findings in patients with COVID-19, pa…
View article: Incidence of thyroid diseases: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
Incidence of thyroid diseases: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) Open
Universidade de São Paulo, São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil.
View article: A practical contemporary approach to decision-making on subclinical hypothyroidism
A practical contemporary approach to decision-making on subclinical hypothyroidism Open
Subclinical hypothyroidism (Shypo) is an increasingly frequent condition in common medical practice. Its diagnosis continues to pose a challenge since a series of non-thyroidal and temporary conditions can elevate serum TSH levels. In addi…
View article: Region-specific reference intervals for TSH in pregnancy: time for changes in Brazil
Region-specific reference intervals for TSH in pregnancy: time for changes in Brazil Open
Over the past few years, the diagnosis of thyroid disorders during pregnancy has emerged as one of the major focuses of debate in clinical thyroidology. Whether we should or not universally screening all pregnant women in the first trimest…
View article: Low thyroid function is not associated with an accelerated deterioration in renal function
Low thyroid function is not associated with an accelerated deterioration in renal function Open
Background Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the effect of thyroid hor…
View article: Increase in the prevalence of abdominal obesity in Brazilian schoo children (2000-2015)
Increase in the prevalence of abdominal obesity in Brazilian schoo children (2000-2015) Open
Introduction: The prevalence of overweight and obese children and adolescents is a public health concern. Few studies have critically evaluated this problem in a Brazilian population, despite the growth of community-based programs to comba…
View article: Thyroid Function Within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis
Thyroid Function Within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis Open
Higher levels of TSH within the reference range may decrease the risk of stroke, highlighting the need for further research focusing on the clinical consequences associated with differences within the reference range of thyroid function.
View article: Thyroid Function Within the Normal Range and Risk of Coronary Heart Disease
Thyroid Function Within the Normal Range and Risk of Coronary Heart Disease Open
Thyrotropin levels within the reference range are not associated with risk of CHD events or CHD mortality. This finding suggests that differences in thyroid function within the population reference range do not influence the risk of CHD. I…
View article: Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis
Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis Open
Although no overall effect of subclinical hypothyroidism on stroke could be demonstrated, an increased risk in subjects younger than 65 years and those with higher TSH concentrations was observed.
View article: Autoimmune thyroid disease: What secrets we still need to unravel?
Autoimmune thyroid disease: What secrets we still need to unravel? Open
Autoimmune thyroid disease (AITD) has been considered the prototypical and the most prevalent organ-specific autoimmune disorder, affecting 2% to 5% of iodine-sufficient population (1). This condition encompasses a clinical-pathological sp…