José Ramón González‐Juanatey
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View article: Advanced electronic consultation between primary care and cardiology: impact of tele-echocardiography and event-based electrocardiographic monitoring
Advanced electronic consultation between primary care and cardiology: impact of tele-echocardiography and event-based electrocardiographic monitoring Open
Background Electronic consultation (e-consultation) has proven effective in optimising communication between primary care and cardiology, reducing waiting times and unnecessary face-to-face referrals. Integrating remote diagnostic tools ma…
View article: Combined SGLT2i and GLP1ra therapy reduces all-cause mortality in people with diabetes, with greater benefit in women
Combined SGLT2i and GLP1ra therapy reduces all-cause mortality in people with diabetes, with greater benefit in women Open
View article: Impact of dapagliflozin on key pathophysiological pathways underlying chronic heart failure progression: the DAPA-MODA biomarker study
Impact of dapagliflozin on key pathophysiological pathways underlying chronic heart failure progression: the DAPA-MODA biomarker study Open
Dapagliflozin favorably modulates several key pathophysiological pathways involved in chronic HF progression, with differential effects among biomarkers by acting particularly on those that are elevated at baseline.
View article: Epigenetic regulation of electromechanical continuity might determine phenotypic heterogeneity in SCN5A mutation carriers in Brugada syndrome
Epigenetic regulation of electromechanical continuity might determine phenotypic heterogeneity in SCN5A mutation carriers in Brugada syndrome Open
Brugada syndrome (BrS) is an inherited cardiac disorder characterized by electrical disturbances. Pathogenic variants in the SCN5A gene are implicated in 25-30% of probands. Although loss-of-function mutations in SCN5A gene drive clinical …
View article: Carvedilol versus flecainide treatment in idiopathic ventricular extrasystoles and tachycardias (CARFLECT IV) trial: Rationale and design
Carvedilol versus flecainide treatment in idiopathic ventricular extrasystoles and tachycardias (CARFLECT IV) trial: Rationale and design Open
This study will be the first clinical trial focused on adults with INVA. The information it provides may influence the choice of pharmacological therapy for the treatment of these arrhythmias.
View article: The Polypill (Acetyl Salicylic Acid, Atorvastatin, and Ramipril) Paradigm Shift in Secondary Prevention: Global Expert Delphi Consensus
The Polypill (Acetyl Salicylic Acid, Atorvastatin, and Ramipril) Paradigm Shift in Secondary Prevention: Global Expert Delphi Consensus Open
Background: The SECURE trial demonstrated that the cardiovascular (CV)-polypill (acetylsalicylic acid [ASA] + atorvastatin + ramipril) reduces CV mortality by 33% in patients with acute myocardial infarction compared to standard care. The …
View article: Effects of GLP-1 agonists on 10-year cardiovascular risk reduction in primary prevention: A 44-week open label prospective study
Effects of GLP-1 agonists on 10-year cardiovascular risk reduction in primary prevention: A 44-week open label prospective study Open
clinicaltrials.gov Identifier: NCT05136287.
View article: Continuity of primary care and its impact on prognosis in patients with heart failure referred for cardiology consultation
Continuity of primary care and its impact on prognosis in patients with heart failure referred for cardiology consultation Open
Objective To assess the prognostic impact of continuity of care (COC), defined as care provided by the same primary care physician (PCP), in patients with heart failure (HF) referred for cardiology consultation. Methods We analyzed all pat…
View article: Soluble guanylate cyclase stimulation improves cardiac function and mitochondrial activity in a rat model of early-stage heart failure with preserved ejection fraction
Soluble guanylate cyclase stimulation improves cardiac function and mitochondrial activity in a rat model of early-stage heart failure with preserved ejection fraction Open
View article: Concomitant Diabetes and Atrial Fibrillation: Epicardial Fat and Macrophage‐Related Mechanisms
Concomitant Diabetes and Atrial Fibrillation: Epicardial Fat and Macrophage‐Related Mechanisms Open
Type 2 diabetes mellitus (T2DM) is present in 25% of patients with atrial fibrillation (AF), the most prevalent arrhythmia in the world. This concomitant disorder enhances thromboembolic events, length of hospital stay after AF ablation, r…
View article: Cost-effectiveness of the CV-polypill strategy versus standard care for secondary cardiovascular prevention in Spain: an analysis based on the SECURE trial
Cost-effectiveness of the CV-polypill strategy versus standard care for secondary cardiovascular prevention in Spain: an analysis based on the SECURE trial Open
View article: Semaglutide Modulates Proinflammatory Epicardial Adipogenesis With Paracrine Effects on hiPSC-Atrial Cardiomyocytes
Semaglutide Modulates Proinflammatory Epicardial Adipogenesis With Paracrine Effects on hiPSC-Atrial Cardiomyocytes Open
View article: Single-chamber pacemakers: with or without leads? Cost-effectiveness and cost-utility analyses
Single-chamber pacemakers: with or without leads? Cost-effectiveness and cost-utility analyses Open
Leadless pacemakers have fewer complications than conventional pacemakers and, although the device itself is more expensive, the leadless pacemaker is more cost-effective in around 90% of cases.
View article: Factors Predicting Myocardial Recovery After Hospitalization for De Novo Heart Failure with Reduced Left Ventricular Ejection Fraction: Results from the COMFE Registry
Factors Predicting Myocardial Recovery After Hospitalization for De Novo Heart Failure with Reduced Left Ventricular Ejection Fraction: Results from the COMFE Registry Open
Background/Objectives: Patients hospitalized for de novo heart failure with reduced ejection fraction (HFrEF) may experience improvement in left ventricular function, a phenomenon associated with improved morbidity and mortality outcomes. …
View article: Endocardial ablation of ganglionated plexus for the treatment of carotid sinus syndrome
Endocardial ablation of ganglionated plexus for the treatment of carotid sinus syndrome Open
Introduction Carotid sinus syndrome (CSS), characterized by exaggerated vagal responses leading to asystolic pauses with carotid sinus massage (CSM), often necessitates pacemaker implantation. This study investigates cardioneuroablation (C…
View article: Combined therapy of SGLT2i and GLP1ra reduces all-cause mortality in diabetic patients with a higher impact on women
Combined therapy of SGLT2i and GLP1ra reduces all-cause mortality in diabetic patients with a higher impact on women Open
Background Combined therapy, sodium-glucose cotransporter 2 inhibitors (SGLT2i), and glucagon-like peptide-1 receptor agonists (GLP1ra), regarding monotherapy reduce causes of mortality in patients with diabetes. However, it might differ b…
View article: NT-proBNP in Acute De Novo Heart Failure: A Key Biomarker for Predicting Myocardial Recovery—COMFE Registry
NT-proBNP in Acute De Novo Heart Failure: A Key Biomarker for Predicting Myocardial Recovery—COMFE Registry Open
This study aims to analyze whether NT-proBNP at admission and discharge in de novo heart failure (HF) with reduced ejection fraction (HFrEF) is associated with myocardial recovery. This is a prospective observational study in two centers. …
View article: Patient-Centered Risk Prediction, Prevention, and Intervention Platform (TIMELY) to Support the Continuum of Care in Coronary Artery Disease Using eHealth and Artificial Intelligence: Protocol for a Randomized Controlled Trial
Patient-Centered Risk Prediction, Prevention, and Intervention Platform (TIMELY) to Support the Continuum of Care in Coronary Artery Disease Using eHealth and Artificial Intelligence: Protocol for a Randomized Controlled Trial Open
Background Cardiac rehabilitation (CR) programs have shown promising results in tertiary prevention. However, achieving sustained behavioral changes remains a challenge. Objective The TIMELY project aims to develop and evaluate a personali…
View article: Sex Differences in Acute Coronary Syndromes: A Scoping Review Across the Care Continuum
Sex Differences in Acute Coronary Syndromes: A Scoping Review Across the Care Continuum Open
Introduction: Optimal diagnosis and management of acute coronary syndrome (ACS) is essential to improve clinical outcomes and prognosis. Sex disparities in ACS care have been reported in the literature, but evidence gaps remain. This revie…
View article: Unsupervised clustering based coronary artery segmentation
Unsupervised clustering based coronary artery segmentation Open
Background The acquisition of 3D geometries of coronary arteries from computed tomography coronary angiography (CTCA) is crucial for clinicians, enabling visualization of lesions and supporting decision-making processes. Manual segmentatio…
View article: Effects of anti-inflammatory therapy in acute heart failure: a systematic review and meta-analysis
Effects of anti-inflammatory therapy in acute heart failure: a systematic review and meta-analysis Open
View article: Coronary sinus unroofing associated with congenitally corrected transposition of the great arteries: a case report
Coronary sinus unroofing associated with congenitally corrected transposition of the great arteries: a case report Open
Background Congenitally corrected transposition of the great arteries (ccTGA) is a rare congenital heart defect that is frequently associated with ventricular septal defects (VSDs) and valvular abnormalities. Advanced cardiac imaging techn…
View article: Effectiveness of the CNIC polypill in secondary cardiovascular prevention in the subgroup of patients of the NEPTUNO study using atorvastatin doses of 20 mg
Effectiveness of the CNIC polypill in secondary cardiovascular prevention in the subgroup of patients of the NEPTUNO study using atorvastatin doses of 20 mg Open
View article: Effect of age on clinical impact and mid-term denervation in patients undergoing cardioneuroablation
Effect of age on clinical impact and mid-term denervation in patients undergoing cardioneuroablation Open
Cardioneuroablation (CNA) represents a promising therapy for recurrent vasovagal syncope (VVS), extrinsically driven atrioventricular block (AVB) and sinus node dysfunction (SND). However, effectiveness in patients aged 50 and above is not…
View article: Transforming Cardiotoxicity Detection in Cancer Therapies: The Promise of MicroRNAs as Precision Biomarkers
Transforming Cardiotoxicity Detection in Cancer Therapies: The Promise of MicroRNAs as Precision Biomarkers Open
Cardiotoxicity (CDTX) is a critical side effect of many cancer therapies, leading to increased morbidity and mortality if not addressed. Early detection of CDTX is essential, and while echocardiographic measures like global longitudinal st…
View article: Delay in cardiology consultation after primary care physician referrals in heart failure: Clinical implications
Delay in cardiology consultation after primary care physician referrals in heart failure: Clinical implications Open
Aims To investigate the association between the elapsed time to cardiology care following a primary care physician (PCP) referral and 1 year outcomes among patients with heart failure (HF). Methods Data from electronic medical records at o…
View article: Endocardial ablation of ganglionated plexus for the treatment of carotid sinus syndrome
Endocardial ablation of ganglionated plexus for the treatment of carotid sinus syndrome Open
Introduction Carotid sinus syndrome (CSS), characterized by exaggerated vagal responses leading to asystolic pauses with carotid sinus massage (CSM), often necessitates pacemaker implantation. This study investigates cardioneuroablation (C…
View article: Cost–Utility Analysis of PCSK9 Inhibitors and Quality of Life: A Two-Year Multicenter Non-Randomized Study
Cost–Utility Analysis of PCSK9 Inhibitors and Quality of Life: A Two-Year Multicenter Non-Randomized Study Open
The primary objective of this study was to conduct a cost–utility analysis of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in real-world, comparing their use with standard care for managing cardiovascular disease. A mul…
View article: Ramipril After Transcatheter Aortic Valve Implantation in Patients Without Reduced Ejection Fraction: The RASTAVI Randomized Clinical Trial
Ramipril After Transcatheter Aortic Valve Implantation in Patients Without Reduced Ejection Fraction: The RASTAVI Randomized Clinical Trial Open
Background Patients with aortic stenosis may continue to have an increased risk of heart failure, arrhythmias, and death after successful transcatheter aortic valve implantation. Renin‐angiotensin system inhibitors may be beneficial in thi…
View article: Colchicine in acutely decompensated heart failure: the COLICA trial
Colchicine in acutely decompensated heart failure: the COLICA trial Open
Background and Aims Acute heart failure (AHF) promotes inflammatory activation, which is associated with worse outcomes. Colchicine has proven effective in other cardiovascular conditions characterized by inflammatory activation, but has n…