Juan Antonio Moreno
YOU?
Author Swipe
View article: Molecular Mechanisms of the Microbiota–Gut–Brain Axis in the Onset and Progression of Stroke
Molecular Mechanisms of the Microbiota–Gut–Brain Axis in the Onset and Progression of Stroke Open
The bidirectional relationship between the brain and gut microbiota has led to the concept of the microbiota–gut–brain axis. It refers to a system of bilateral communication that integrates neuronal, immunological, and metabolic signals, w…
View article: Direct In-Sample Sequencing of the 3′ Transcriptome Expands the Capabilities of Optical Pooled Screens
Direct In-Sample Sequencing of the 3′ Transcriptome Expands the Capabilities of Optical Pooled Screens Open
We present a platform that directly sequences single guide RNAs and endogenous 3′UTRs in fixed cells while simultaneously measuring protein abundance and cellular morphology. We demonstrate platform capability by performing optical pooled …
View article: Increased tumor necrosis factor-receptor superfamily plasma levels are associated with early renal or retinal involvement in intermediate hyperglycemia
Increased tumor necrosis factor-receptor superfamily plasma levels are associated with early renal or retinal involvement in intermediate hyperglycemia Open
BACKGROUND Diabetes and its associated microvascular complications, such as nephropathy and retinopathy, significantly impact global health. These complications often begin in the prediabetic stage, emphasizing the importance of early dete…
View article: Association between subclinical haemolysis and periprocedural outcomes in patients undergoing transcatheter aortic valve replacement
Association between subclinical haemolysis and periprocedural outcomes in patients undergoing transcatheter aortic valve replacement Open
Pre-procedural haemolysis might be present in TAVI candidates and is associated with increased peri-procedural and 30-day complications. Pre-procedural haemolysis may serve as a marker of elevated procedural risk.
View article: Adaptations of mitochondrial, autophagy and nutrient sensing pathways in the liver from long-lived mice overexpressing CYB5R3 are sex-dependent and involve inter-organ responses
Adaptations of mitochondrial, autophagy and nutrient sensing pathways in the liver from long-lived mice overexpressing CYB5R3 are sex-dependent and involve inter-organ responses Open
Cytochrome b 5 reductase 3 (CYB5R3) overexpression mimics several metabolic benefits of calorie restriction, with sex- and tissue-specific effects. This study aimed to investigate how CYB5R3 overexpression impacts hepatic metabolism in you…
View article: Oxidative stress and inflammation on metabolic abnormalities and renal involvement in prediabetic subjects across Europe
Oxidative stress and inflammation on metabolic abnormalities and renal involvement in prediabetic subjects across Europe Open
These results highlight the important associations of oxidative stress and inflammation with metabolic abnormalities linked to the prediabetic state and its complications such as fatty liver and renal involvement. Although these results ne…
View article: Prevalence and factors linked to renal involvement in prediabetes patients across Europe in the ePREDICE trial
Prevalence and factors linked to renal involvement in prediabetes patients across Europe in the ePREDICE trial Open
View article: Oxidative stress and inflammation on metabolic abnormalities and renal involvement in prediabetic subjects across Europe
Oxidative stress and inflammation on metabolic abnormalities and renal involvement in prediabetic subjects across Europe Open
Background: Studying the mechanisms involved in the transition from prediabetes to diabetes and its associated complications, such as kidney disease, is a growing challenge. This study focuses on identifying valuable biomarkers for the ear…
View article: Prevalence and factors associated with renal involvement in subjects with prediabetes across Europe.The ePREDICE trial
Prevalence and factors associated with renal involvement in subjects with prediabetes across Europe.The ePREDICE trial Open
This sub-analysis of the ePREDICE trial, investigated the prevalence and determinants of renal complications, specifically glomerular hyperfiltration, albuminuria, and reduced kidney function, in individuals with prediabetes (PD). The coho…
View article: CYB5R3 overexpression exhibits sexual dimorphism: Mitochondrial and metabolic adaptations in transgenic female mice during calorie restriction
CYB5R3 overexpression exhibits sexual dimorphism: Mitochondrial and metabolic adaptations in transgenic female mice during calorie restriction Open
There is a pressing need to develop new strategies for enhancing health in the elderly and preventing the rise in age-related diseases. Calorie restriction without malnutrition (CR) stands among the different antiaging interventions. Lifel…
View article: Cytochrome <i>b</i><sub>5</sub> reductase 3 overexpression and dietary nicotinamide riboside supplementation promote distinctive mitochondrial alterations in distal convoluted tubules of mouse kidneys during aging
Cytochrome <i>b</i><sub>5</sub> reductase 3 overexpression and dietary nicotinamide riboside supplementation promote distinctive mitochondrial alterations in distal convoluted tubules of mouse kidneys during aging Open
The kidney undergoes structural and physiological changes with age, predominantly studied in glomeruli and proximal tubules. However, limited knowledge is available about the impact of aging and anti‐aging interventions on distal tubules. …
View article: WCN24-2179 EXPECTED RENAL FUNCTION IN POST-KIDNEY TRANSPLANTATION NOT ACHIEVED DUE TO RENAL ARTERY STENOSIS. A CASE REPORT
WCN24-2179 EXPECTED RENAL FUNCTION IN POST-KIDNEY TRANSPLANTATION NOT ACHIEVED DUE TO RENAL ARTERY STENOSIS. A CASE REPORT Open
Transplant renal artery stenosis (TRAS) is a well-recognized vascular complication after kidney transplant. It occurs most frequently in the first 6 months after kidney transplant, and is one of the major causes of graft loss and premature…
View article: Semaglutide Improves Liver Steatosis and De Novo Lipogenesis Markers in Obese and Type-2-Diabetic Mice with Metabolic-Dysfunction-Associated Steatotic Liver Disease
Semaglutide Improves Liver Steatosis and De Novo Lipogenesis Markers in Obese and Type-2-Diabetic Mice with Metabolic-Dysfunction-Associated Steatotic Liver Disease Open
Metabolic-dysfunction-associated steatotic liver disease (MASLD) is a prevalent clinical condition associated with elevated morbidity and mortality rates. Patients with MASLD treated with semaglutide, a glucagon-like peptide-1 receptor ago…
View article: Tweak/Fn14 system is involved in rhabdomyolysis-induced acute kidney injury
Tweak/Fn14 system is involved in rhabdomyolysis-induced acute kidney injury Open
Spanish Ministry of Science and Innovation, ISCIII and Junta de Andalucía.
View article: Intravascular hemolysis triggers <scp>NAFLD</scp> characterized by a deregulation of lipid metabolism and lipophagy blockade
Intravascular hemolysis triggers <span>NAFLD</span> characterized by a deregulation of lipid metabolism and lipophagy blockade Open
Intravascular hemolysis is a common feature of different clinical entities, including sickle cell disease and malaria. Chronic hemolytic disorders are associated with hepatic damage; however, it is unknown whether heme disturbs lipid metab…
View article: Effect of Immunosuppressive Treatments on Kidney Outcomes After Gross Hematuria-Related Acute Kidney Injury in Older Patients With IgA Nephropathy
Effect of Immunosuppressive Treatments on Kidney Outcomes After Gross Hematuria-Related Acute Kidney Injury in Older Patients With IgA Nephropathy Open
View article: #4392 TWEAK/FN14 SYSTEM IS INVOLVED IN RHABDOMYOLYSIS-INDUCED ACUTE KIDNEY INJURY
#4392 TWEAK/FN14 SYSTEM IS INVOLVED IN RHABDOMYOLYSIS-INDUCED ACUTE KIDNEY INJURY Open
Background and Aims Rhabdomyolysis is a pathological syndrome associated with massive and severe skeletal muscle injury. A common complication of rhabdomyolysis is acute kidney injury (AKI), a process that increases mortality of these pati…
View article: POS1038 NAD+ BOOSTERS AS A NOVEL ANTI-INFLAMMATORY TOOL IN RHEUMATOID ARTHRITIS PATIENTS
POS1038 NAD+ BOOSTERS AS A NOVEL ANTI-INFLAMMATORY TOOL IN RHEUMATOID ARTHRITIS PATIENTS Open
View article: Preclinical Characterization of Pharmacologic <scp>NAD</scp><sup>+</sup> Boosting as a Promising Therapeutic Approach in Rheumatoid Arthritis
Preclinical Characterization of Pharmacologic <span>NAD</span><sup>+</sup> Boosting as a Promising Therapeutic Approach in Rheumatoid Arthritis Open
Objective We analyzed NAD + metabolism in patients with rheumatoid arthritis (RA), its association with disease activity and clinical outcomes of RA, and the therapeutic potential of pharmacologic NAD + boosting. Methods Our study included…
View article: Editorial: NRF2 signaling pathway: New insights in the field of reno-cardiovascular health
Editorial: NRF2 signaling pathway: New insights in the field of reno-cardiovascular health Open
EDITORIAL article Front. Pharmacol., 17 April 2023Sec. Renal Pharmacology Volume 14 - 2023 | https://doi.org/10.3389/fphar.2023.1193005
View article: P-2 DE NOVO LIPOGENESIS MARKERS ARE INVOLVED IN METABOLIC ASSOCIATED FATTY LIVER DISEASE PROGRESSION IN BTBR OB/OB MICE
P-2 DE NOVO LIPOGENESIS MARKERS ARE INVOLVED IN METABOLIC ASSOCIATED FATTY LIVER DISEASE PROGRESSION IN BTBR OB/OB MICE Open
Introduction and Objectives: The new recommendations suggesting changing the current nomenclature from Non-Alcoholic Fatty Liver Disease (NAFLD) to Metabolic associated fatty liver disease (MAFLD) are primarily aimed at improving the under…
View article: TWEAK/Fn14 System is Involved in Rhabdomyolysis-Induced Acute Kidney Injury
TWEAK/Fn14 System is Involved in Rhabdomyolysis-Induced Acute Kidney Injury Open
View article: Assessment of waste sludge from chemical industry as sulphate-based additive in cements
Assessment of waste sludge from chemical industry as sulphate-based additive in cements Open
View article: Cardiovascular-related proteomic changes in ECFCs exposed to the serum of COVID-19 patients
Cardiovascular-related proteomic changes in ECFCs exposed to the serum of COVID-19 patients Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection significantly affects the cardiovascular system, causing vascular damage and thromboembolic events in critical patients. Endothelial dysfunction represents one of the f…
View article: Role of Toll‐like receptor 4 in intravascular hemolysis‐mediated injury
Role of Toll‐like receptor 4 in intravascular hemolysis‐mediated injury Open
Massive intravascular hemolysis is a common characteristic of several pathologies. It is associated with the release of large quantities of heme into the circulation, promoting injury in vulnerable organs, mainly kidney, liver, and spleen.…
View article: The Role of Non-Coding RNAs in Kidney Diseases
The Role of Non-Coding RNAs in Kidney Diseases Open
Renal diseases include different pathologies, such as acute kidney injury (AKI), chronic kidney disease (CKD), end-stage renal disease (ESRD), diabetic nephropathy (DN), kidney cancer, polycystic kidney disease, etc [...]
View article: Serum microRNAs targeting ACE2 and RAB14 genes distinguish asymptomatic from critical COVID-19 patients
Serum microRNAs targeting ACE2 and RAB14 genes distinguish asymptomatic from critical COVID-19 patients Open
View article: Silica nanoparticles induce neurotoxicity in striatum region by activating oxidative stress and apoptosis-related gene expression in adult male rats: Possible involvement of Nrf2/HO-1 and apoptotic pathways
Silica nanoparticles induce neurotoxicity in striatum region by activating oxidative stress and apoptosis-related gene expression in adult male rats: Possible involvement of Nrf2/HO-1 and apoptotic pathways Open
Extensive use of silica nanoparticles (SiNPs) in biomedical and industrial fields has increased the risk of exposure, resulting in concerns about their safety. However, information regarding their neurotoxic effects through different pathw…
View article: Post-COVID Complications after Pressure Ulcer Surgery in Patients with Spinal Cord Injury Associate with Creatine Kinase Upregulation in Adipose Tissue
Post-COVID Complications after Pressure Ulcer Surgery in Patients with Spinal Cord Injury Associate with Creatine Kinase Upregulation in Adipose Tissue Open
The risk of complications following surgical procedures is significantly increased in patients with SARS-CoV-2 infection. However, the mechanisms underlying these correlations are not fully known. Spinal cord injury (SCI) patients who unde…
View article: The serum of COVID-19 asymptomatic patients up-regulates proteins related to endothelial dysfunction and viral response in circulating angiogenic cells ex-vivo
The serum of COVID-19 asymptomatic patients up-regulates proteins related to endothelial dysfunction and viral response in circulating angiogenic cells ex-vivo Open