José Javier Conesa
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View article: Two photon-responsive gold nanocapsules enable targeted photothermal hyperthermia of chemoresistant melanoma: injection-route-dependent efficacy and renal evidence of fragment clearance
Two photon-responsive gold nanocapsules enable targeted photothermal hyperthermia of chemoresistant melanoma: injection-route-dependent efficacy and renal evidence of fragment clearance Open
Gold–polymer nanocapsules enable image-guided, intratumoural photothermal therapy of melanoma. Intrinsic properties allow for two-photon luminescence imaging prior to local heating.
View article: Author response: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
Author response: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin Open
Full text Figures and data Peer review Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Appendix 1 Data availability References Article and author information Metrics Abstract Epithelial intercel…
View article: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin Open
Epithelial intercellular adhesion molecule (ICAM)-1 is apically polarized, interacts with, and guides leukocytes across epithelial barriers. Polarized hepatic epithelia organize their apical membrane domain into bile canaliculi and ducts, …
View article: Author Response: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
Author Response: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin Open
Epithelial Intercellular Adhesion Molecule (ICAM)-1 is apically polarized, interacts with and guides leukocytes across epithelial barriers. Polarized hepatic epithelia organize their apical membrane domain into bile canaliculi and ducts, w…
View article: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin Open
Epithelial Intercellular Adhesion Molecule (ICAM)-1 is apically polarized, interacts with and guides leukocytes across epithelial barriers. Polarized hepatic epithelia organize their apical membrane domain into bile canaliculi and ducts, w…
View article: Joint Public Review: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
Joint Public Review: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin Open
Epithelial Intercellular Adhesion Molecule (ICAM)-1 is apically polarized, interacts with and guides leukocytes across epithelial barriers. Polarized hepatic epithelia organize their apical membrane domain into bile canaliculi and ducts, w…
View article: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin Open
Epithelial Intercellular Adhesion Molecule (ICAM)-1 is apically polarized, interacts with and guides leukocytes across epithelial barriers. Polarized hepatic epithelia organize their apical membrane domain into bile canaliculi and ducts, w…
View article: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin Open
Epithelial intercellular adhesion molecule (ICAM)-1 is apically polarized, interacts with, and guides leukocytes across epithelial barriers. Polarized hepatic epithelia organize their apical membrane domain into bile canaliculi and ducts, …
View article: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin Open
Epithelial Intercellular Adhesion Molecule (ICAM)-1 is apically polarized, interacts with and guides leukocytes across epithelial barriers. Polarized hepatic epithelia organize their apical membrane domain into bile canaliculi and ducts, w…
View article: Growth hormone remodels the 3D-structure of the mitochondria of inflammatory macrophages and promotes metabolic reprogramming
Growth hormone remodels the 3D-structure of the mitochondria of inflammatory macrophages and promotes metabolic reprogramming Open
Introduction Macrophages are a heterogeneous population of innate immune cells that support tissue homeostasis through their involvement in tissue development and repair, and pathogen defense. Emerging data reveal that metabolism may contr…
View article: Interplay between septins and ubiquitin-mediated xenophagy during <i>Shigella</i> entrapment
Interplay between septins and ubiquitin-mediated xenophagy during <i>Shigella</i> entrapment Open
Septins are cytoskeletal proteins implicated in numerous cellular processes including cytokinesis and morphogenesis. In the case of infection by Shigella flexneri, septins assemble into cage-like structures that entrap cytosolic bac…
View article: Septins and K63 ubiquitin chains are present in separate bacterial microdomains during autophagy of entrapped <i>Shigella</i>
Septins and K63 ubiquitin chains are present in separate bacterial microdomains during autophagy of entrapped <i>Shigella</i> Open
During host cell invasion, Shigella escapes to the cytosol and polymerizes actin for cell-to-cell spread. To restrict cell-to-cell spread, host cells employ cell-autonomous immune responses including antibacterial autophagy and septin cage…
View article: Septins and K63 chains form separate bacterial microdomains during autophagy of entrapped<i>Shigella</i>
Septins and K63 chains form separate bacterial microdomains during autophagy of entrapped<i>Shigella</i> Open
During host cell invasion, Shigella escapes to the cytosol and polymerizes actin for cell-to-cell spread. To restrict cell-to-cell spread, host cells employ cell-autonomous immune responses including antibacterial autophagy and septin cage…
View article: Growth hormone remodels the 3D-structure of the mitochondria of inflammatory macrophages and promotes metabolic reprogramming
Growth hormone remodels the 3D-structure of the mitochondria of inflammatory macrophages and promotes metabolic reprogramming Open
Macrophages are a heterogeneous population of innate immune cells that support tissue homeostasis through their involvement in tissue development and repair, and pathogen defense. Emerging data reveal that metabolism may control macrophage…
View article: ScipionTomo: Towards cryo-electron tomography software integration, reproducibility, and validation
ScipionTomo: Towards cryo-electron tomography software integration, reproducibility, and validation Open
View article: Multiphoton imaging of melanoma 3D models with plasmonic nanocapsules
Multiphoton imaging of melanoma 3D models with plasmonic nanocapsules Open
We report the synthesis of plasmonic nanocapsules and the cellular responses they induce in 3D melanoma models for their perspective use as a photothermal therapeutic agent. The wall of the nanocap- sules is composed of polyelectrolytes. T…
View article: Multiphoton imaging of melanoma 3D models with plasmonic nanocapsules
Multiphoton imaging of melanoma 3D models with plasmonic nanocapsules Open
Dataset of https://www.sciencedirect.com/science/article/pii/S1742706122000617?via%3Dihub#fig0001
View article: Multiphoton imaging of melanoma 3D models with plasmonic nanocapsules
Multiphoton imaging of melanoma 3D models with plasmonic nanocapsules Open
Dataset of https://www.sciencedirect.com/science/article/pii/S1742706122000617?via%3Dihub#fig0001
View article: Multiphoton imaging of melanoma 3D models with plasmonic nanocapsules
Multiphoton imaging of melanoma 3D models with plasmonic nanocapsules Open
View article: Structural analysis of receptors and actin polarity in platelet protrusions
Structural analysis of receptors and actin polarity in platelet protrusions Open
Significance Platelet activation induces reorganization of the cell and the formation of cellular protrusions, pseudopodia. These processes are accompanied by remodeling of the actin cytoskeleton and the activation of platelet integrins, w…
View article: <i>Scipion</i> for tomography: an expansion of the <i>Scipion</i> software framework towards integration, reproducibility and validation in cryo-electron tomography
<i>Scipion</i> for tomography: an expansion of the <i>Scipion</i> software framework towards integration, reproducibility and validation in cryo-electron tomography Open
View article: Calcite as a Precursor of Hydroxyapatite in the Early Biomineralization of Differentiating Human Bone-Marrow Mesenchymal Stem Cells
Calcite as a Precursor of Hydroxyapatite in the Early Biomineralization of Differentiating Human Bone-Marrow Mesenchymal Stem Cells Open
Biomineralization is the process by which living organisms generate organized mineral crystals. In human cells, this phenomenon culminates with the formation of hydroxyapatite, which is a naturally occurring mineral form of calcium apatite…
View article: Outside Front Cover: (Biotechnology Journal 3/2021)
Outside Front Cover: (Biotechnology Journal 3/2021) Open
The cover image is based on the Research Article Multimodal Imaging and Soft X-Ray Tomography of Fluorescent Nanodiamonds in Cancer Cells by Philipp Reineck et al., https://doi.org/10.1002/biot.202000289.
View article: Algorithmic robustness to preferred orientations in single particle analysis by CryoEM
Algorithmic robustness to preferred orientations in single particle analysis by CryoEM Open
The presence of preferred orientations in single particle analysis (SPA) by cryo-Electron Microscopy (cryoEM) is currently one of the hurdles preventing many structural analyses from yielding high-resolution structures. Although the existe…
View article: Correlative 3D cryo X-ray imaging reveals intracellular location and effect of designed antifibrotic protein–nanomaterial hybrids
Correlative 3D cryo X-ray imaging reveals intracellular location and effect of designed antifibrotic protein–nanomaterial hybrids Open
A novel 3D cryo correlative approach locates designed therapeutic protein–nanomaterial hybrids in whole cells with high specificity and resolution. Detection of treatment-induced morphological changes, crucial for pre-clinical studies, are…
View article: Multiphoton Imaging of Melanoma 3D Models with Plasmonic Nanocapsules
Multiphoton Imaging of Melanoma 3D Models with Plasmonic Nanocapsules Open
View article: Four-Dimensional Characterization of the <i>Babesia divergens</i> Asexual Life Cycle, from the Trophozoite to the Multiparasite Stage
Four-Dimensional Characterization of the <i>Babesia divergens</i> Asexual Life Cycle, from the Trophozoite to the Multiparasite Stage Open
Babesiosis is a disease caused by intraerythrocytic Babesia parasites, which possess many clinical features that are similar to those of malaria. This worldwide disease is increasing in frequency and geographical range and has a significan…
View article: Four-dimensional characterization of the<i>Babesia divergens</i>asexual life cycle: from the trophozoite to the multiparasite stage
Four-dimensional characterization of the<i>Babesia divergens</i>asexual life cycle: from the trophozoite to the multiparasite stage Open
Babesia is an apicomplexan parasite of significance that causes the disease known as babesiosis in domestic and wild animals and in humans worldwide. Babesia infects vertebrate hosts and reproduces asexually by a form of binary fission wit…
View article: Multiparametric analysis of the effectiveness of cisplatin on cutaneous squamous carcinoma cells using two different types of adjuvants
Multiparametric analysis of the effectiveness of cisplatin on cutaneous squamous carcinoma cells using two different types of adjuvants Open
The objective of this study was to regulate the cytotoxicity of cisplatin (cisPt) minimizing its adverse effects. For this purpose, the lowest cisPt concentration needed to obtain a significant positive response in cutaneous squamous cell …
View article: <i>Trypanosoma brucei</i>ultra-structure cell modifications caused by knockdown of the ribonuclease Rrp44/Dis3
<i>Trypanosoma brucei</i>ultra-structure cell modifications caused by knockdown of the ribonuclease Rrp44/Dis3 Open
Rrp44/Dis3 is an essential protein conserved in all eukaryotes that functions in the maturation of many different RNA precursors and RNA surveillance. The Trypanosoma brucei Rrp44/Dis3 homologue (TbRRP44) is required for maturation of pre-…