Jose K. James
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View article: Experience With an Optical Character Recognition Search Application for Review of Outside Medical Records
Experience With an Optical Character Recognition Search Application for Review of Outside Medical Records Open
Electronic health records (EHRs) have been widely adopted in medical practice, yet clinicians often struggle to find important clinical information, owing to factors such as "note bloat"1. Outside medical records (OMRs) are often cluttered…
View article: Review article: An overview of exosomes in biology and their potential applications in regenerative medicine
Review article: An overview of exosomes in biology and their potential applications in regenerative medicine Open
Extracellular vesicles (EVs), commonly acknowledged as Exosomes, are tiny, single-membrane, secreted organelles that range in size from 40 to 150 nm. They are noticeably abundant in various proteins, lipids, nucleic acids, and glycoconjuga…
View article: Deep generative models of LDLR protein structure to predict variant pathogenicity
Deep generative models of LDLR protein structure to predict variant pathogenicity Open
The complex structure and function of low density lipoprotein receptor (LDLR) makes classification of protein-coding missense variants challenging. Deep generative models, including Evolutionary model of Variant Effect (EVE), Evolutionary …
View article: Demographic Trends in Emergency Department Visits for Psychiatric Concerns During the COVID-19 Pandemic
Demographic Trends in Emergency Department Visits for Psychiatric Concerns During the COVID-19 Pandemic Open
In this multisite study, total ED visits declined during the pandemic; however, psychiatric visits declined less than nonpsychiatric visits. Black patients experienced a greater increase in psychiatric emergencies than other demographic gr…
View article: Phyla-specific Correlated Dynamics in Tropomyosin
Phyla-specific Correlated Dynamics in Tropomyosin Open
Tropomyosin (Tpm) is a continuous α-helical coiled-coil homodimer that regulates actinomyosin interactions in muscle. We examined extended molecular simulations of four Tpms, two from the vertebrate phylum Chordata (rat and pig), and two f…
View article: A comparison of biophysical characterization techniques in predicting monoclonal antibody stability
A comparison of biophysical characterization techniques in predicting monoclonal antibody stability Open
With the rapid growth of biopharmaceutical product development, knowledge of therapeutic protein stability has become increasingly important. We evaluated assays that measure solution-mediated interactions and key molecular characteristics…