Jose L. Cadavid
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View article: Correction: Analysis of an engineered organoid model of pancreatic cancer identifies hypoxia as a contributing factor in determining transcriptional subtypes
Correction: Analysis of an engineered organoid model of pancreatic cancer identifies hypoxia as a contributing factor in determining transcriptional subtypes Open
View article: Analysis of an engineered organoid model of pancreatic cancer identifies hypoxia as a contributing factor in determining transcriptional subtypes
Analysis of an engineered organoid model of pancreatic cancer identifies hypoxia as a contributing factor in determining transcriptional subtypes Open
Pancreatic ductal adenocarcinoma (PDAC) is a high-mortality cancer characterized by its aggressive, treatment-resistant phenotype and a complex tumour microenvironment (TME) featuring significant hypoxia. Bulk transcriptomic analysis has i…
View article: Systems biology framework for rational design of operational conditions for<i>in vitro / in vivo</i>translation of microphysiological systems
Systems biology framework for rational design of operational conditions for<i>in vitro / in vivo</i>translation of microphysiological systems Open
Preclinical models are used extensively to study diseases and potential therapeutic treatments. Complex in vitro platforms incorporating human cellular components, known as microphysiological systems (MPS), can model cellular and microenvi…
View article: Bridging systems biology and tissue engineering: Unleashing the full potential of complex 3D <i>in vitro</i> tissue models of disease
Bridging systems biology and tissue engineering: Unleashing the full potential of complex 3D <i>in vitro</i> tissue models of disease Open
Rapid advances in tissue engineering have resulted in more complex and physiologically relevant 3D in vitro tissue models with applications in fundamental biology and therapeutic development. However, the complexity provided by these model…
View article: Single-cell analysis of an engineered organoid-based model of pancreatic cancer identifies hypoxia as a contributing factor in the determination of transcriptional subtypes
Single-cell analysis of an engineered organoid-based model of pancreatic cancer identifies hypoxia as a contributing factor in the determination of transcriptional subtypes Open
Pancreatic ductal adenocarcinoma (PDAC) is a high-mortality cancer characterized by its aggressive, treatment-resistant phenotype and a complex tumour microenvironment (TME) featuring significant hypoxia. Bulk transcriptomic analysis has i…
View article: Discovery: Transition of an Inquiry-focused Learning Program to a Virtual Platform During the COVID-19 Pandemic (Evaluation)
Discovery: Transition of an Inquiry-focused Learning Program to a Virtual Platform During the COVID-19 Pandemic (Evaluation) Open
The shift to distance learning in response to the COVID-19 pandemic has presented teachers and students with several challenges. Teachers have found themselves quickly creating distance learning materials to provide equal or greater educat…
View article: An Engineered 3D Co-culture Model of Primary Macrophages and Patient-Derived Tumour Cells to Explore Cellular Responses in the Graded Hypoxic Microenvironment of Pancreatic Cancer
An Engineered 3D Co-culture Model of Primary Macrophages and Patient-Derived Tumour Cells to Explore Cellular Responses in the Graded Hypoxic Microenvironment of Pancreatic Cancer Open
In pancreatic ductal adenocarcinoma (PDAC), tumour associated macrophages (TAMs) are a heterogeneous immune cell population that interact with cancer cells to promote malignancy, chemo-resistance, and immunosuppression. Aside from TAMs, hy…
View article: An Automation Workflow for High‐Throughput Manufacturing and Analysis of Scaffold‐Supported 3D Tissue Arrays
An Automation Workflow for High‐Throughput Manufacturing and Analysis of Scaffold‐Supported 3D Tissue Arrays Open
Patient‐derived organoids have emerged as a useful tool to model tumour heterogeneity. Scaling these complex culture models while enabling stratified analysis of different cellular sub‐populations, however, remains a challenge. One strateg…
View article: An automation workflow for high-throughput manufacturing and analysis of scaffold-supported 3D tissue arrays
An automation workflow for high-throughput manufacturing and analysis of scaffold-supported 3D tissue arrays Open
The success rate of bringing novel cancer therapies to the clinic remains extremely low due to the lack of relevant pre-clinical culture models that capture the complexity of human tumours. Patient-derived organoids have emerged as a usefu…
View article: An off-the-shelf multi-well scaffold-supported platform for tumour organoid-based tissues
An off-the-shelf multi-well scaffold-supported platform for tumour organoid-based tissues Open
Complex 3D bioengineered tumour models provide the opportunity to better capture the heterogeneity of patient tumours. Patient-derived organoids are emerging as a useful tool to study tumour heterogeneity and variation in patient responses…
View article: REVOLVER: A low-cost automated protein purifier based on parallel preparative gravity column workflows
REVOLVER: A low-cost automated protein purifier based on parallel preparative gravity column workflows Open
Protein purification is a ubiquitous procedure in biochemistry and the life sciences, and represents a key step in the protein production pipeline. The need for scalable and parallel protein purification systems is driven by the demands fo…
View article: REVOLVER: a low-cost automated protein purifier based on parallel preparative gravity column workflows
REVOLVER: a low-cost automated protein purifier based on parallel preparative gravity column workflows Open
Protein purification is a ubiquitous operation in biochemistry and life sciences and represents a key step to producing purified proteins for research (understanding how proteins work) and various applications. The need for scalable and pa…
View article: Discovery: Differential Student Impact is Evident Within an Inquiry-focused Secondary/Post-secondary Collaborative STEM Program
Discovery: Differential Student Impact is Evident Within an Inquiry-focused Secondary/Post-secondary Collaborative STEM Program Open
Introduction: Curriculum for high school students who participate in a science, technology, engineering, and math (STEM) are generally focused on delivery of knowledge in effort to ensure achievement of learning outcomes related to importa…
View article: Discovery: Virtual Implementation of Inquiry-Based Remote Learning for Secondary STEM Students During the COVID-19 Pandemic
Discovery: Virtual Implementation of Inquiry-Based Remote Learning for Secondary STEM Students During the COVID-19 Pandemic Open
View article: The life cycle of cancer-associated fibroblasts within the tumour stroma and its importance in disease outcome
The life cycle of cancer-associated fibroblasts within the tumour stroma and its importance in disease outcome Open
The tumour microenvironment (TME) determines vital aspects of tumour development, such as tumour growth, metastases and response to therapy. Cancer-associated fibroblasts (CAFs) are abundant and extremely influential in this process and in…
View article: Gels for Live Analysis of Compartmentalized Environments (GLAnCE): A Tissue Model to Probe Tumour Phenotypes at Tumour-Stroma Interfaces
Gels for Live Analysis of Compartmentalized Environments (GLAnCE): A Tissue Model to Probe Tumour Phenotypes at Tumour-Stroma Interfaces Open
The interface between a tumour and the adjacent stroma is a site of great importance for tumour development. At this site, carcinoma cells are highly proliferative, undergo invasive phenotypic changes, and directly interact with surroundin…