Jose M. Carmena
YOU?
Author Swipe
View article: Dopamine D1 receptor activation in the striatum is sufficient to drive reinforcement of anteceding cortical patterns
Dopamine D1 receptor activation in the striatum is sufficient to drive reinforcement of anteceding cortical patterns Open
Timed dopamine signals underlie reinforcement learning, favoring neural activity patterns that drive behaviors with positive outcomes. In the striatum, dopamine activates five dopamine receptors (D1R-D5R), which are differentially expresse…
View article: Distinct neural representations during a brain–machine interface and manual reaching task in motor cortex, prefrontal cortex, and striatum
Distinct neural representations during a brain–machine interface and manual reaching task in motor cortex, prefrontal cortex, and striatum Open
Although brain–machine interfaces (BMIs) are directly controlled by the modulation of a select local population of neurons, distributed networks consisting of cortical and subcortical areas have been implicated in learning and maintaining …
View article: Invariant neural dynamics drive commands to control different movements
Invariant neural dynamics drive commands to control different movements Open
It has been proposed that the nervous system has the capacity to generate a wide variety of movements because it reuses some invariant code. Previous work has identified that dynamics of neural population activity are similar during differ…
View article: Distinct neural representations during a brain-machine interface and manual reaching task in motor cortex, prefrontal cortex, and striatum
Distinct neural representations during a brain-machine interface and manual reaching task in motor cortex, prefrontal cortex, and striatum Open
Although brain-machine interfaces (BMIs) are directly controlled by the modulation of a select local population of neurons, distributed networks consisting of cortical and subcortical areas have been implicated in learning and maintaining …
View article: Zippi_Shvartsman_et_al_2023_bmi_manual_files
Zippi_Shvartsman_et_al_2023_bmi_manual_files Open
Included files:Each file includes LFP (local field potential) data for both animals (‘h’, ‘y’) during a particular type of task control (‘bmi’ or ‘manual’) and time-locked to 500ms before or after a particular event in the task (‘go_cue’ o…
View article: Zippi_Shvartsman_et_al_2023_baseline_files
Zippi_Shvartsman_et_al_2023_baseline_files Open
Included files:Each file includes LFP (local field potential) data for both animals (‘h’, ‘y’) during rest periods for each day (‘baseline’) without any time-locking (500ms segments were randomly selected from baseline in our analyses). Se…
View article: A neural model of proximity to reward
A neural model of proximity to reward Open
Throughout learning, refinement of cortical activity in cortex, a process termed “credit assignment”, underlies the refinement of behavioral actions leading to reward. While previous research shows striatum’s role in linking behavior to re…
View article: Left hemisphere dominance for bilateral kinematic encoding in the human brain
Left hemisphere dominance for bilateral kinematic encoding in the human brain Open
Neurophysiological studies in humans and nonhuman primates have revealed movement representations in both the contralateral and ipsilateral hemispheres. Inspired by clinical observations, we ask if this bilateral representation differs for…
View article: Selective modulation of cortical population dynamics during neuroprosthetic skill learning
Selective modulation of cortical population dynamics during neuroprosthetic skill learning Open
Datasets analyzed in Zippi, You, et al., 2022 to study cortical population dynamics during neuroprosthetic skill learning in populations of neurons whose activity serves as direct input to a brain-machine interface decoder (direct subpopul…
View article: Author response: Left hemisphere dominance for bilateral kinematic encoding in the human brain
Author response: Left hemisphere dominance for bilateral kinematic encoding in the human brain Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Neurophys…
View article: Hybrid dedicated and distributed coding in PMd/M1 provides separation and interaction of bilateral arm signals
Hybrid dedicated and distributed coding in PMd/M1 provides separation and interaction of bilateral arm signals Open
Pronounced activity is observed in both hemispheres of the motor cortex during preparation and execution of unimanual movements. The organizational principles of bi-hemispheric signals and the functions they serve throughout motor planning…
View article: Skilled independent control of individual motor units via a non-invasive neuromuscular–machine interface
Skilled independent control of individual motor units via a non-invasive neuromuscular–machine interface Open
Objective. Brain–machine interfaces (BMIs) have the potential to augment human functions and restore independence in people with disabilities, yet a compromise between non-invasiveness and performance limits their relevance. Approach. Here…
View article: Diverse operant control of different motor cortex populations during learning
Diverse operant control of different motor cortex populations during learning Open
During motor learning, as well as during neuroprosthetic learning, animals learn to control motor cortex activity in order to generate behavior. Two different population of motor cortex neurons, intra-telencephalic (IT) and pyramidal tract…
View article: Invariant neural dynamics drive commands to control different movements
Invariant neural dynamics drive commands to control different movements Open
Summary It has been proposed that the nervous system has the capacity to generate a wide variety of movements because it re-uses some invariant code. Previous work has identified that dynamics of neural population activity are similar duri…
View article: Left Hemisphere Dominance for Bilateral Kinematic Encoding in the Human Brain
Left Hemisphere Dominance for Bilateral Kinematic Encoding in the Human Brain Open
Neurophysiological studies in humans and non-human primates have revealed movement representations in both the contralateral and ipsilateral hemisphere. Inspired by clinical observations, we ask if this bilateral representation differs for…
View article: A non-invasive brain-machine interface via independent control of individual motor units
A non-invasive brain-machine interface via independent control of individual motor units Open
Brain-machine interfaces (BMIs) have the potential to augment human functions and restore independence in people with disabilities, yet a compromise between non-invasiveness and performance limits their relevance. Here, we demonstrate a BM…
View article: Selective modulation of population dynamics during neuroprosthetic skill learning
Selective modulation of population dynamics during neuroprosthetic skill learning Open
Learning to control a brain-machine interface (BMI) is associated with the emergence of coordinated neural dynamics in populations of neurons whose activity serves as direct input to the BMI decoder (direct subpopulation). While previous w…
View article: Inferring system-level brain communication through multi-scale neural activity
Inferring system-level brain communication through multi-scale neural activity Open
Fundamental principles underlying computation in multi-scale brain networks illustrate how multiple brain areas and their coordinated activity give rise to complex cognitive functions. Whereas the population brain activity has been studied…
View article: Hybrid dedicated and distributed coding in PMd/M1 provides separation and interaction of bilateral arm signals
Hybrid dedicated and distributed coding in PMd/M1 provides separation and interaction of bilateral arm signals Open
Pronounced activity is observed in both hemispheres of the motor cortex during preparation and execution of unimanual movements. The organizational principles of bi-hemispheric signals and the functions they serve throughout motor planning…
View article: Head-mounted microendoscopic calcium imaging in dorsal premotor cortex of behaving rhesus macaque
Head-mounted microendoscopic calcium imaging in dorsal premotor cortex of behaving rhesus macaque Open
Summary A major effort is now underway across the brain sciences to identify, characterize and manipulate mesoscale neural circuits in order to elucidate the mechanisms underlying sensory perception, cognition and behavior. Optical imaging…
View article: StimDust: A wireless millimetre-scale implantable neural stimulator with ultrasonically powered bidirectional communication: Raw data
StimDust: A wireless millimetre-scale implantable neural stimulator with ultrasonically powered bidirectional communication: Raw data Open
Raw, pre-processed data for StimDust. "A wireless millimetre-scale implantable neural stimulator with ultrasonically powered bidirectional communication", as published in Nature Biomedical Engineering, 2020
View article: Flexible Modulation of Neural Variance Facilitates Neuroprosthetic Skill Learning
Flexible Modulation of Neural Variance Facilitates Neuroprosthetic Skill Learning Open
SUMMARY One hallmark of natural motor control is the brain’s ability to adapt to perturbations ranging from temporary visual-motor rotations to paresis caused by stroke. These adaptations require modifications of learned neural patterns th…
View article: A Sub-mm$^3$ Ultrasonic Free-floating Implant for Multi-mote Neural Recording
A Sub-mm$^3$ Ultrasonic Free-floating Implant for Multi-mote Neural Recording Open
A 0.8 mm$^3$ wireless, ultrasonically powered, free-floating neural recording implant is presented. The device is comprised only of a 0.25 mm$^2$ recording IC and a single piezoceramic resonator that is used for both power harvesting and d…