Explanipedia

Bis- and Azabis(oxazoline)–Copper–Tungstophosphate Immobilized on Mesoporous Silica: Preparation and Use as Catalyst in Enantioselective Cyclopropanation Open

Daniela Mansilla, Luis R. Pizzio, José A. Mayoral, José M. Fraile, M. Rosario Torviso · 2025

Tungstophosphoric acid (TPA) has been supported on mesoporous silicas prepared using urea as the pore forming agent. The amount of urea (20, 30, or 40% w/w) influences the silica specific surface area (SBET), total pore volume (Vp), and av…

Origin of the Urease Inhibition of <i>Metschnikowia pulcherrima</i> Extracts: Comparative Assays with Synthetic Pulcherriminic Acid and Cyclo-dileucine Open

Rosa Aligué, Sergio Atarés, Vicente Dorado, Inés Jimeno, Ignasi Salaet , et al. · 2024

The objective of this work was to determine whether pulcherriminic acid was responsible for the urease inhibition activity of the extracts of the yeast Metschnikowia pulcherrima. Pulcherriminic acid was synthesized through a seven-step pat…

Collagen-Laponite Nanoclay Hydrogels for Tumor Spheroid Growth Open

Pilar Alamán‐Díez, Carlos Borau, Pedro Enrique Guerrero, H. Amaveda, M. Mora , et al. · 2024

The extracellular matrix (ECM) plays an important regulatory role in the development and progression of tumoral tissue. Its functions and properties are crucial in determining tumor cell behavior such as invasion, migration, and malignancy…

Corrigendum to “Laponite for biomedical applications: An ophthalmological perspective” [Mater. Today Bio 24 (2024) 100935] Open

María Jesús Rodrigo, M. J. Cardiel, José M. Fraile, José A. Mayoral, Luís E. Pablo , et al. · 2024

[This corrects the article DOI: 10.1016/j.mtbio.2023.100935.].

Sulfonic Resins as Catalysts for the Oxidation of Alcohols with H2O2/KBr Open

Vicente Dorado, Clara I. Herrerı́as, José M. Fraile · 2024

Sulfonic resins can replace homogeneous sulfonic acids in the oxidation of alcohols with the H2O2/KBr system. The performance of different resins was tested with methyl 9(10)-hydroxystearate, a secondary fatty alcohol. The structural featu…

Laponite for biomedical applications: An ophthalmological perspective Open

María Jesús Rodrigo, M. J. Cardiel, José M. Fraile, José A. Mayoral, Luís E. Pablo , et al. · 2023

Clay minerals have been applied in biomedicine for thousands of years. Laponite is a nanostructured synthetic clay with the capacity to retain and progressively release drugs. In recent years there has been a resurgence of interest in Lapo…

Catalytic hydrolysis of epoxyfatty esters with solid sulfonic acids Open

Vicente Dorado, Clara I. Herrerı́as, José M. Fraile · 2023

Collagen-Laponite Nanoclay Hydrogels for Tumor Spheroid Growth Open

Pilar Alamán‐Díez, Carlos Borau, Pedro Enrique Guerrero, H. Amaveda, M. Mora , et al. · 2023

The extracellular matrix (ECM) plays an important regulatory role in the development and progression of tumoral tissue. Its functions and properties are crucial in determining tumor cell behavior such as invasion, migration, and malignancy…

Simple metal-free oxidative cleavage of 1,2-diols Open

Vicente Dorado, Clara I. Herrerı́as, José M. Fraile · 2023

New insights into the interaction of triethylphosphine oxide with silica surface: exchange between different surface species Open

Elísabet Pires, José M. Fraile · 2022

TEPO adsorbed on silica shows a single signal, due to mobility, and three types of adsorption modes, physisorption, chemisorption through one H-bond and through two H-bonds, as demonstrated by 31 P solid state NMR at different surface cove…

Synthesis of hydroxyfatty esters by sequential epoxidation-hydrogenolysis: Solvent effects Open

Vicente Dorado, Clara I. Herrerı́as, José M. Fraile · 2021

Monitoring New Long-Lasting Intravitreal Formulation for Glaucoma with Vitreous Images Using Optical Coherence Tomography Open

María Jesús Rodrigo, Amaya Pérez del Palomar, Alberto Montolío, Silvia Méndez-Martínez, Manuel Subías , et al. · 2021

Intravitreal injection is the gold standard therapeutic option for posterior segment pathologies, and long-lasting release is necessary to avoid reinjections. There is no effective intravitreal treatment for glaucoma or other optic neuropa…

Functionalization of Porous Cellulose with Glyoxyl Groups as a Carrier for Enzyme Immobilization and Stabilization Open

Sandro Martins de Oliveira, Susana Velasco‐Lozano, Alejandro H. Orrego, Javier Rocha‐Martín, Sonia Moreno‐Pérez , et al. · 2021

The functionalization of the internal surface of macroporous carriers with glyoxyl groups has proven to highly stabilize a large variety of enzymes through multipoint covalent immobilization. In this work, we have translated the surface ch…

Monitoring New Long-Lasting Intravitreal Formulation for Glaucoma with Vitreous Images Using Optical Coherence Tomography Open

María Jesús Rodrigo, Amaya Pérez del Palomar, Alberto Montolío, Silvia Méndez-Martínez, Manuel Subías , et al. · 2020

Intravitreal injection is the gold standard therapeutic option for posterior segment pathologies, and long-lasting release is necessary to avoid reinjections. There is no effective intravitreal treatment for glaucoma or other optic neuropa…

Dexamethasone delivery to the ocular posterior segment by sustained-release Laponite formulation Open

Esther Prieto, M. J. Cardiel, Eugenio Vispe, M IDOIPE, Elena García‐Martín , et al. · 2020

This paper presents a novel nanoformulation for sustained-release delivery of dexamethasone (DEX) to the ocular posterior segment using a Laponite (LAP) carrier-DEX/LAP 1:10 w w^-1 formulation; 10 mg ml^-1. In vivo ocul…

Comparison of Chemical and Enzymatic Methods for the Transesterification of Waste Fish Oil Fatty Ethyl Esters with Different Alcohols Open

Beatriz Hernanz Angulo, José M. Fraile, L. Briones, Clara I. Herrerı́as · 2020

Fatty acid esters of 2-ethyl-1-hexanol (EH), 2-hexyl-1-decanol (HD), and isopropanol have been obtained from a mixture of ethyl esters obtained as a fish oil byproduct. Homogeneous base catalysis with alkaline hydroxides and alkoxides has …

Synthesis of fatty ketoesters by tandem epoxidation–rearrangement with heterogeneous catalysis Open

Vicente Dorado, Lena Gil, José A. Mayoral, Clara I. Herrerı́as, José M. Fraile · 2020

Fatty ketoesters are obtained from unsaturated fatty esters in a tandem two-step process with a combination of two heterogeneous catalysts, without intermediate purification and with maximum productivity of the catalysts through recycling …

Study of interactions between Brønsted acids and triethylphosphine oxide in solution by <sup>31</sup>P NMR: evidence for 2 : 1 species Open

Elísabet Pires, José M. Fraile · 2020

³¹P chemical shift of TEPO–acid 1 : 1 species correlates with pK_a. The evolution at higher molar ratios indicate a second TEPO–acid interaction.

Sulfonated Hydrothermal Carbons from Cellulose and Glucose as Catalysts for Glycerol Ketalization Open

Pablo S. Fernández, José M. Fraile, Enrique García‐Bordejé, Elísabet Pires · 2019

Solketal is one of the most used glycerol-derived solvents. Its production via heterogeneous catalysis is crucial for avoiding important product losses typically found in the aqueous work-up in homogeneous catalysis. In this work, we prese…

Catalytic routes for the synthesis of high added value products from fatty esters Open

Vicente Dorado, José M. Fraile, Clara I. Herrerı́as · 2018

Resumen del póster presentado al ICIQ - INTECAT School, celebrado en Tarragona (España) del 11 al 13 de diciembre de 2018.

Sulfonated hydrothermal carbons as catalysts for organic reactions Open

José M. Fraile, José Enrique García-Bordejé, Elísabet Pires · 2018

Trabajo presentado al 8th International Symposium on Carbon for Catalysis (CarboCat), celebrado en Oporto (Portugal) del 26 al 29 de junio de 2018.

Application of Heterogeneous Catalysts in the First Steps of the Oseltamivir Synthesis Open

José M. Fraile, Carlos J. Saavedra · 2017

The first steps of oseltamivir synthesis from quinic acid involve acetalization and ester formation. These reactions are catalyzed by either acids or bases, which may be accomplished by heterogeneous catalysts. Sulfonic solids are efficien…

Síntesis de ciclopropanos funcionalizados a partir de ésteres grasos insaturados Open

Beatriz Hernanz Angulo, José M. Fraile, Clara I. Herrerı́as, José A. Mayoral · 2017

Póster presentado a la Reunión de la Sociedad Española de Catálisis: "Catálisis, confluencia interdisciplinar: modelos, catalizadores y reactores", celebrada en Barcelona (España) del 13 al 15 de julio de 2015.

Parametric study of the hydrothermal carbonization of cellulose and effect of acidic conditions Open

Enrique García‐Bordejé, Elísabet Pires, José M. Fraile · 2017

Comparison of Ta–MCM-41 and Ti–MCM-41 as catalysts for the enantioselective epoxidation of styrene with TBHP Open

Marwa Fadhli, I. Khedher, José M. Fraile · 2017

Chiral Ti–MCM-41 and Ta–MCM-41 catalysts have been prepared by grafting of Ti(O i Pr) 4 and Ta(OEt) 5 and the modification with R -(+)-diethyl l -tartrate or R -(+)-diisopropyl l -tartrate. In general, the solid catalysts are more active a…

Synthetic Transformations for the Valorization of Fatty Acid Derivatives Open

José I. Garcı́a, José M. Fraile, Clara I. Herrerı́as, Elísabet Pires · 2017

Oleochemistry is a growing field from an industrial point of view, and it is fundamental to more sustainable chemical production that is less dependent on fossil sources. From this point of view, the development of selective and efficient …

Síntesis de ésteres de isosorbide a partir de sorbitol usando P-3 catalizadores heterogéneos Open

Carlos J. Saavedra, José M. Fraile · 2017

Resumen del póster presentado a la XXI Semana Científica “Antonio González”, celebrada en La Universidad de La Laguna, Tenerife (España) del 24 al 27 de octubre de 2017.

Challenging cyclopropanation reactions on non-activated double bonds of fatty esters Open

Beatriz Hernanz Angulo, José M. Fraile, Clara I. Herrerı́as, José A. Mayoral · 2017

Cyclopropanation reactions in the chain of unsaturated fatty esters is a good strategy for the ready preparation of potential monomers for polymerization.

Mecanismo de acidólisis de modelos de lignina Open

José M. Fraile, Zoel Hormigón, José A. Mayoral, Carlos J. Saavedra, Luis Salvatella · 2017

Resumen del póster presentado a la XXXVI Reunión Bienal de la Real Sociedad Española de Química (RSEQ), celebrada en Sitges, Barcelona (España) del 25 al 29 de junio de 2017.

Estudio de despolimerización de modelos de lignina en medio ácido Open

Carlos J. Saavedra, José M. Fraile, Zoel Hormigón, José A. Mayoral, Luis Salvatella · 2017

Resumen del póster presentado a la XXI Semana Científica “Antonio González”, celebrada en La Universidad de La Laguna, Tenerife (España) del 24 al 27 de octubre de 2017.

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