José M. Pumar
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View article: Predicting Stroke Etiology with Radiomics: A Retrospective Study
Predicting Stroke Etiology with Radiomics: A Retrospective Study Open
Background/Objectives: The composition of the thrombus is not taken into account in the etiology determination of patients with acute ischemic stroke (AIS); however, it varies depending on the origin of the thrombus, as atherothrombotic th…
View article: Predicting Stroke Etiology with Radiomics: A Retrospective Study
Predicting Stroke Etiology with Radiomics: A Retrospective Study Open
Background/Objectives: The composition of the thrombus is not taken into account in the etiology defemination of patients with acute ischemic stroke (AIS), however, it varies depending on the origin of the thrombus, as atherothrombotic thr…
View article: Is Personalized Mechanical Thrombectomy Based on Clot Characteristics Feasible? A Radiomics Model Using NCECT to Predict FPE in AIS Patients Undergoing Thromboaspiration
Is Personalized Mechanical Thrombectomy Based on Clot Characteristics Feasible? A Radiomics Model Using NCECT to Predict FPE in AIS Patients Undergoing Thromboaspiration Open
Background/Objectives: In patients with acute ischemic stroke (AIS), the first pass effect (FPE) refers to the complete recanalization of an occluded vessel (TICI = 2C/3) with a single thrombectomy attempt. Achieving complete vessel recana…
View article: Is Personalized Mechanical Thrombectomy Based on Clot Characteristics Feasible? A Radiomics Model Using NCECT to Predict FPE in AIS Patients Undergoing Thromboaspiration
Is Personalized Mechanical Thrombectomy Based on Clot Characteristics Feasible? A Radiomics Model Using NCECT to Predict FPE in AIS Patients Undergoing Thromboaspiration Open
Background/Objectives: In patients with acute ischemic stroke (AIS), the first pass effect (FPE) refers to the complete recanalization of an occluded vessel (TICI = 2C/3) with a single thrombectomy attempt. Achieving complete vessel recana…
View article: Precision Medicine for Blood Glutamate Grabbing in Ischemic Stroke
Precision Medicine for Blood Glutamate Grabbing in Ischemic Stroke Open
Glutamate grabbers, such as glutamate oxaloacetate transaminase (GOT), have been proposed to prevent excitotoxicity secondary to high glutamate levels in stroke patients. However, the efficacy of blood glutamate grabbing by GOT could be de…
View article: Technical success, procedural safety, and efficacy of the Silk Vista Baby in the treatment of cerebral aneurysms over a mid-to-long-term follow-up
Technical success, procedural safety, and efficacy of the Silk Vista Baby in the treatment of cerebral aneurysms over a mid-to-long-term follow-up Open
Background Long-term follow-up of cerebral aneurysms treated with the Silk Vista Baby (SVB) flow diverter is lacking. This study aimed to assess the technical success, procedural safety, and efficacy of the SVB (Balt, Montmorency, France) …
View article: Systemic biomarker associated with poor outcome after futile reperfusion
Systemic biomarker associated with poor outcome after futile reperfusion Open
Background Successful recanalization does not lead to complete tissue reperfusion in a considerable percentage of ischemic stroke patients. This study aimed to identify biomarkers associated with futile recanalization. Leukoaraiosis predic…
View article: Differential blood-based biomarkers of subcortical and deep brain small vessel disease
Differential blood-based biomarkers of subcortical and deep brain small vessel disease Open
Background: Cerebral small vessel disease is the most common cause of lacunar strokes (LS). Understanding LS pathogenesis is vital for predicting disease severity, prognosis, and developing therapies. Objectives: To research molecular prof…
View article: How Can Radiomics Help the Clinical Management of Patients with Acute Ischemic Stroke?
How Can Radiomics Help the Clinical Management of Patients with Acute Ischemic Stroke? Open
Acute ischemic stroke (AIS) is the loss of neurological function due to a sudden reduction in cerebral blood flow and is a leading cause of disability and death worldwide. The field of radiological imaging has experienced growth in recent …
View article: How Can Radiomics Help the Clinical Management of Patients with Acute Ischemic Stroke?
How Can Radiomics Help the Clinical Management of Patients with Acute Ischemic Stroke? Open
Acute ischemic stroke (AIS) is the loss of neurological function due to a sudden reduction in cerebral blood flow and is a leading cause of disability and death worldwide. In recent years, the field of radiological imaging has experienced …
View article: Perfusion-weighted software written in Python for DSC-MRI analysis
Perfusion-weighted software written in Python for DSC-MRI analysis Open
Introduction Dynamic susceptibility-weighted contrast-enhanced (DSC) perfusion studies in magnetic resonance imaging (MRI) provide valuable data for studying vascular cerebral pathophysiology in different rodent models of brain diseases (s…
View article: Influence of Temperature Chronobiology on Stroke Outcome
Influence of Temperature Chronobiology on Stroke Outcome Open
The circadian system regulates numerous physiological variables, including body temperature. Additionally, a circadian patter has been described in stroke onset. Considering this, we hypothesised that the chronobiology of temperature may h…
View article: Surrogate biomarkers of outcome for wake-up ischemic stroke
Surrogate biomarkers of outcome for wake-up ischemic stroke Open
View article: Thrombectomy aspiration post-market study in acute stroke with the Q aspiration catheter: the TAPAS study
Thrombectomy aspiration post-market study in acute stroke with the Q aspiration catheter: the TAPAS study Open
Background The Q Aspiration Catheter (MIVI Neuro) has demonstrated greater aspiration flow rates and ingestion forces compared with conventional catheters in vitro. The safety and performance of the Q Catheter was assessed using a direct a…
View article: Antihyperthermic Treatment in the Management of Malignant Infarction of the Middle Cerebral Artery
Antihyperthermic Treatment in the Management of Malignant Infarction of the Middle Cerebral Artery Open
Malignant infarction of the middle cerebral artery (m-MCA) is a complication of ischemic stroke. Since hyperthermia is a predictor of poor outcome, and antihyperthermic treatment is well tolerated, our main aim was to analyze whether the s…
View article: The Smoking Paradox in Stroke Patients Under Reperfusion Treatment Is Associated With Endothelial Dysfunction
The Smoking Paradox in Stroke Patients Under Reperfusion Treatment Is Associated With Endothelial Dysfunction Open
Objective This study aimed to explore the association between smoking habit and the serum levels of soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK), in relation with the functional outcome of patients with acute ische…
View article: Surrogate biomarkers of outcome for wake-up ischemic stroke
Surrogate biomarkers of outcome for wake-up ischemic stroke Open
Background: Wake-up ischemic stroke (IS) has been usually excluded from acute stroke therapy options for being outside of the safe treatment window. We identified risk factors, and clinical or molecular biomarkers that could be therapeutic…
View article: <scp>sTWEAK</scp> is a leukoaraiosis biomarker associated with neurovascular angiopathy
<span>sTWEAK</span> is a leukoaraiosis biomarker associated with neurovascular angiopathy Open
Objective Leukoaraiosis (LA) refers to white matter lesions of undetermined etiology associated with the appearance and worsening of vascular pathologies. The aim is to confirm an increased frequency and intensity of LA in symptomatic pati…
View article: Five-Years Angiographic Follow-Up of Wide-Neck Intracranial Aneurysms Treated With LEO Plus Stent
Five-Years Angiographic Follow-Up of Wide-Neck Intracranial Aneurysms Treated With LEO Plus Stent Open
Background: This study aimed to evaluate the angiographic and clinical outcome, with an emphasis on long-term follow-up, of the LEO Plus stent for wide-neck intracranial aneurysms treated in a single center. Methods: We retrospectively exa…
View article: Calcified cerebral embolism: a 9-case series and review of the literature
Calcified cerebral embolism: a 9-case series and review of the literature Open
CCE is more frequent than previously thought and, although the condition continues to be underdiagnosed, it is of considerable prognostic relevance in the aetiological study of stroke.
View article: Initial Experience Performing Mechanical Thrombectomy With the CatchView Mini Device for Distal M2 Segment Middle Cerebral Artery Occlusions
Initial Experience Performing Mechanical Thrombectomy With the CatchView Mini Device for Distal M2 Segment Middle Cerebral Artery Occlusions Open
Background: Mechanical thrombectomy (MT) has become the standard of care for acute ischemic stroke due to large vessel occlusion; however, its safety and efficacy in patients with distal strokes remains unclear. In this study, we investiga…
View article: EP63 The TAPAS study: thrombectomy aspiration post-market study in acute stroke
EP63 The TAPAS study: thrombectomy aspiration post-market study in acute stroke Open
Introduction The Q Aspiration catheter design has shown increased aspiration force in bench studies1. The objective of this first clinical study was to assess safety and performance of the Q™ Catheter in a real-world setting. Th…
View article: Characterization of a Temporal Profile of Biomarkers as an Index for Ischemic Stroke Onset Definition
Characterization of a Temporal Profile of Biomarkers as an Index for Ischemic Stroke Onset Definition Open
Background and purpose: Stroke is a dynamic process in terms of molecular mechanisms, with prominent glutamate-mediated excitotoxicity at the onset of symptoms followed by IL-6-mediated inflammation. Our aim was to study a serum glutamate/…
View article: Treatment of Intracranial Aneurysms Using the New Silk Vista Flow Diverter: Safety Outcomes at Short-Term Follow-Up
Treatment of Intracranial Aneurysms Using the New Silk Vista Flow Diverter: Safety Outcomes at Short-Term Follow-Up Open
Background: Flow diverters are widely used as the first endovascular treatment option for complex brain aneurysms due to their high percentage of occlusion and low morbi-mortality. The Silk Vista device is a new generation of flow diverter…
View article: Neurological Instability in Ischemic Stroke: Relation with Outcome, Latency Time, and Molecular Markers
Neurological Instability in Ischemic Stroke: Relation with Outcome, Latency Time, and Molecular Markers Open
View article: sTWEAK as Predictor of Stroke Recurrence in Ischemic Stroke Patients Treated With Reperfusion Therapies
sTWEAK as Predictor of Stroke Recurrence in Ischemic Stroke Patients Treated With Reperfusion Therapies Open
Aim: The purpose of this study was to investigate clinical and neuroimaging factors associated with stroke recurrence in reperfused ischemic stroke patients, as well as the influence of specific biomarkers of inflammation and endothelial d…
View article: Recanalization and rupture of a brain aneurysm completely occluded with a LEO stent nine years ago
Recanalization and rupture of a brain aneurysm completely occluded with a LEO stent nine years ago Open
View article: sTWEAK is a marker of early haematoma growth and leukoaraiosis in intracerebral haemorrhage
sTWEAK is a marker of early haematoma growth and leukoaraiosis in intracerebral haemorrhage Open
Objective To study the association between early growth of haematoma with biomarkers of endothelial dysfunction such as leukoaraiosis (LA) and the soluble tumour necrosis factor-like weak inducer of apoptosis (sTWEAK) in patients with intr…
View article: Letter by Rodríguez-Castro et al Regarding Article, “Embolic Stroke of Undetermined Source and Symptomatic Nonstenotic Carotid Disease”
Letter by Rodríguez-Castro et al Regarding Article, “Embolic Stroke of Undetermined Source and Symptomatic Nonstenotic Carotid Disease” Open
View article: The presence of leukoaraiosis enhances the association between sTWEAK and hemorrhagic transformation
The presence of leukoaraiosis enhances the association between sTWEAK and hemorrhagic transformation Open
Objective To investigate whether elevated serum levels of sTWEAK (soluble tumor necrosis factor‐like inducer of apoptosis) might be involved in a higher frequency of symptomatic hemorrhagic transformation (HT) through the presence of leuko…