José Manuel Asencio
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View article: Diagnosis and Therapy of Soft Tissue Sarcomas: Spanish Group for Research in Sarcomas (GEIS) Guidelines
Diagnosis and Therapy of Soft Tissue Sarcomas: Spanish Group for Research in Sarcomas (GEIS) Guidelines Open
Soft tissue sarcomas (STSs) are a rare and highly heterogeneous group of tumours originating from mesenchymal cells, characterized by significant clinical and biological diversity. Due to this complexity, STSs present considerable challeng…
View article: Diagnostic Delay in Soft Tissue Sarcomas: A Review
Diagnostic Delay in Soft Tissue Sarcomas: A Review Open
Background/Objectives: To review the problem of diagnostic delay in soft tissue sarcomas with the aim of identifying its causes and consequences, understanding how to clinically suspect and refer them, and evaluating the main limitations o…
View article: Ibero-American Consensus for the Management of Liver Metastases of Soft Tissue Sarcoma: Updated Review and Clinical Recommendations
Ibero-American Consensus for the Management of Liver Metastases of Soft Tissue Sarcoma: Updated Review and Clinical Recommendations Open
Liver metastases from soft tissue sarcoma (STS) (excluding gastrointestinal stromal tumors) are rare and more commonly arise from retroperitoneal and intra-abdominal primary sites. Chemotherapy remains the mainstay of treatment for dissemi…
View article: A Window into the Brain’s Microcirculation: Retinal Optical Coherence Tomography Angiography (OCTA) as Perioperative Bedside Resuscitation Guide?
A Window into the Brain’s Microcirculation: Retinal Optical Coherence Tomography Angiography (OCTA) as Perioperative Bedside Resuscitation Guide? Open
Objective Quantifying physiological flow dynamics in the brain’s microvasculature is vital for effective resuscitation management. Traditional resuscitation approaches rely on macrocirculatory flow targets, which often poorly correlate wit…
View article: Risk factors for readmission of COVID-19 ICU survivors: A three-year follow up
Risk factors for readmission of COVID-19 ICU survivors: A three-year follow up Open
Background & objectives Evidence suggests that individuals who have been hospitalised due to COVID-19 are more susceptible to future mortality and readmission, thereby imposing a substantial strain on their quality of life. The available d…
View article: Dynamics of Ischemia/Reperfusion Injury Markers During Normothermic Liver Machine Perfusion
Dynamics of Ischemia/Reperfusion Injury Markers During Normothermic Liver Machine Perfusion Open
Background. A comprehensive mechanistic assessment of normothermic machine perfusion (NMP) is an essential step toward identifying biomarkers to assess liver viability. Although some studies have evaluated the effect of NMP on inflammation…
View article: Ibero-American Consensus for the Management of Peritoneal Sarcomatosis: Updated Review and Clinical Recommendations
Ibero-American Consensus for the Management of Peritoneal Sarcomatosis: Updated Review and Clinical Recommendations Open
Peritoneal sarcomatosis is a rare malignant disease with a poor prognosis, secondary to peritoneal dissemination of abdominopelvic soft tissue sarcomas. Its rarity, together with the characteristic histological heterogeneity and the histor…
View article: Internal and external validation of indocyanine green plasma disappearance rate to discard liver grafts before procurement
Internal and external validation of indocyanine green plasma disappearance rate to discard liver grafts before procurement Open
ICG clearance test performed in DBD was internally and externally validated to predict liver graft discard. It could be used as a screening tool before donation to avoid unnecessary costs of travel and human resources.
View article: Circumferential Inferior Vena Cavectomy Without Caval Replacement in the Management of Renal Cell Carcinoma with Tumor Thrombus
Circumferential Inferior Vena Cavectomy Without Caval Replacement in the Management of Renal Cell Carcinoma with Tumor Thrombus Open
Purpose of Review Renal cell carcinoma presents a unique proclivity for vascular involvement giving rise to a peculiar form of locally advanced disease so-called tumor thrombus. To date, the only curative strategy for these cases remains s…
View article: Feasibility and Short-Term Outcomes in Liver-First Approach: A Spanish Snapshot Study (the RENACI Project)
Feasibility and Short-Term Outcomes in Liver-First Approach: A Spanish Snapshot Study (the RENACI Project) Open
(1) Background: The liver-first approach may be indicated for colorectal cancer patients with synchronous liver metastases to whom preoperative chemotherapy opens a potential window in which liver resection may be undertaken. This study ai…
View article: Textbook outcomes in the liver-first approach for colorectal liver metastases: prospective multicentre analysis
Textbook outcomes in the liver-first approach for colorectal liver metastases: prospective multicentre analysis Open
Background Textbook outcome is a valuable tool for assessing surgical outcomes. The aim of this study was to analyse textbook-outcome rates in the prospective Spanish National Registry of the Liver-First Approach (RENACI Project) and the f…
View article: Recent advances in gastrointestinal stromal tumors: where are we going?
Recent advances in gastrointestinal stromal tumors: where are we going? Open
Gastrointestinal Stromal Sarcomas (GIST) are mesenchymal neoplasms whose incidence accounts for 1-2% of digestive tumors, being located in the stomach (55-60%) and small intestine (30%).The most important advances in recent years are focus…
View article: Evaluation of the validated intraoperative bleeding scale in liver surgery: study protocol for a multicenter prospective study
Evaluation of the validated intraoperative bleeding scale in liver surgery: study protocol for a multicenter prospective study Open
Background Surgical hemostasis has become one of the key principles in the advancement of surgery. Hemostatic agents are commonly administered in many surgical specialties, although the lack of consensus on the definition of intraoperative…
View article: Updated Review and Clinical Recommendations for the Diagnosis and Treatment of Patients with Retroperitoneal Sarcoma by the Spanish Sarcoma Research Group (GEIS)
Updated Review and Clinical Recommendations for the Diagnosis and Treatment of Patients with Retroperitoneal Sarcoma by the Spanish Sarcoma Research Group (GEIS) Open
Soft tissue sarcomas (STS) are an uncommon and biologically heterogeneous group of tumors arising from mesenchymal cells. The incidence is estimated at five cases per 100,000 people per year. Retroperitoneal sarcomas (RPS) account for 10–1…
View article: Rectal and esophageal gastrointestinal stromal tumors—how to deal with it?—technical approach and role of neoadjuvant treatment
Rectal and esophageal gastrointestinal stromal tumors—how to deal with it?—technical approach and role of neoadjuvant treatment Open
Rectal and esophageal gastrointestinal stromal tumors (GISTs) are rare entities that require evaluation at specialized centers. The primary goal of surgical treatment is complete tumor resection. A thorough anatomical assessment is crucial…
View article: 2023 GEIS Guidelines for gastrointestinal stromal tumors
2023 GEIS Guidelines for gastrointestinal stromal tumors Open
Gastrointestinal stromal tumor (GIST) is the most common malignant neoplasm of mesenchymal origin. GIST spans a wide clinical spectrum that ranges from tumors with essentially no metastatic potential to malignant and life-threatening sprea…
View article: Neoadjuvant therapy impact in early pancreatic cancer: “bioborderline” vs. “non-bioborderline”
Neoadjuvant therapy impact in early pancreatic cancer: “bioborderline” vs. “non-bioborderline” Open
A neoadjuvant strategy seemed to improve local control and the survival of patients with early pancreatic cancer, both those with elevated CA19-9 and normal marker levels.
View article: Clinical feasibility of combining intraoperative electron radiation therapy with minimally invasive surgery: a potential for electron-FLASH clinical development
Clinical feasibility of combining intraoperative electron radiation therapy with minimally invasive surgery: a potential for electron-FLASH clinical development Open
Background Local cancer therapy by combining real-time surgical exploration and resection with delivery of a single dose of high-energy electron irradiation entails a very precise and effective local therapeutic approach. Integrating the b…
View article: Surgical Principles of Primary Retroperitoneal Sarcoma in the Era of Personalized Treatment: A Review of the Frontline Extended Surgery
Surgical Principles of Primary Retroperitoneal Sarcoma in the Era of Personalized Treatment: A Review of the Frontline Extended Surgery Open
Surgery is the key treatment in retroperitoneal sarcoma (RPS), as completeness of resection is the most important prognostic factor related to treatment. Compartmental surgery/frontline extended approach is based on soft-tissue sarcoma sur…
View article: Intra-Operative Electron Radiation Therapy: An Update of the Evidence Collected in 40 Years to Search for Models for Electron-FLASH Studies
Intra-Operative Electron Radiation Therapy: An Update of the Evidence Collected in 40 Years to Search for Models for Electron-FLASH Studies Open
Introduction: The clinical practice and outcome results of intraoperative electron radiation therapy (IOeRT) in cancer patients have been extensively reported over 4 decades. Electron beams can be delivered in the promising FLASH dose rate…
View article: Advances in neoadjuvant therapy for resectable pancreatic cancer over the past two decades
Advances in neoadjuvant therapy for resectable pancreatic cancer over the past two decades Open
In the last two decades, pancreatic cancer has been undergoing important changes in its perioperative management due to the great interest in multidisciplinary management and preoperative multimodal therapy, which in numerous studies have …
View article: ESTRO/ACROP IORT recommendations for intraoperative radiation therapy in primary locally advanced rectal cancer
ESTRO/ACROP IORT recommendations for intraoperative radiation therapy in primary locally advanced rectal cancer Open
Carcinoma of the rectum is a heterogeneous disease. The clinical spectrum identifies a subset of patients with locally advanced tumours that are close to or involve adjoining structures, such as the sacrum, pelvic sidewalls, prostate or bl…
View article: ESTRO IORT Task Force/ACROP recommendations for intraoperative radiation therapy in borderline-resected pancreatic cancer
ESTRO IORT Task Force/ACROP recommendations for intraoperative radiation therapy in borderline-resected pancreatic cancer Open
Radiation therapy (RT) is a valuable component of multimodal treatment for localized pancreatic cancer. Intraoperative radiation therapy (IORT) is a very precise RT modality to intensify the irradiation effect for cancer involving upper ab…