José Manuel Benítez del Castillo
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View article: A narrative literature review about alpha‐lipoic acid role in dry eye and ocular surface disease
A narrative literature review about alpha‐lipoic acid role in dry eye and ocular surface disease Open
Ocular surface diseases (OSD) include various conditions that affect the eye's surface, causing discomfort and pain. One such condition, dry eye disease (DED), is a multifactorial disorder that significantly impacts patients' quality of li…
View article: IMPULSE Study: Impact of COVID-19 in the present of ophthalmology focusing on ocular surface and future trends
IMPULSE Study: Impact of COVID-19 in the present of ophthalmology focusing on ocular surface and future trends Open
During the pandemic, an increase in the incidence of certain ocular surface diseases has been perceived. The telematic follow-up of chronic or mild pathologies of the ocular surface entails the need to provide specific training for both th…
View article: Estudio IMPULSO: impacto de la COVID-19 en el presente de la oftalmología centrada en superficie ocular y tendencias de futuro
Estudio IMPULSO: impacto de la COVID-19 en el presente de la oftalmología centrada en superficie ocular y tendencias de futuro Open
View article: Long-Term Effects of Adipose-Derived Stem Cells for the Treatment of Bilateral Limbal Stem Cell Deficiency
Long-Term Effects of Adipose-Derived Stem Cells for the Treatment of Bilateral Limbal Stem Cell Deficiency Open
To determine the safety and feasibility of human autologous adipose tissue-derived adult mesenchymal stem cells (ASCs) for ocular surface regeneration in patients with bilateral limbal stem-cell deficiency (LSCD). A phase IIa clinical tria…
View article: Management of inflammation in dry eye disease: Recommendations from a European panel of experts
Management of inflammation in dry eye disease: Recommendations from a European panel of experts Open
Introduction Early initiation of anti-inflammatory therapies is recommended for dry eye disease (DED) to break the vicious cycle of pathophysiology. However, there is limited guidance on how to implement topical ciclosporin (CsA) and corti…
View article: Therapeutic Response After Immunosuppressive Drug Prescription in Non-infectious Uveitis: A Survival Analysis
Therapeutic Response After Immunosuppressive Drug Prescription in Non-infectious Uveitis: A Survival Analysis Open
Factors associated with GTR to ISDs may help to identify patients with NIUs who could benefit from a thorough follow-up.
View article: Hypochlorous acid as an antiseptic in the care of patients with suspected COVID-19 infection
Hypochlorous acid as an antiseptic in the care of patients with suspected COVID-19 infection Open
View article: Association of Dry Eye with Laryngopharyngeal Reflux in Clinical Practice
Association of Dry Eye with Laryngopharyngeal Reflux in Clinical Practice Open
Patients with DED are at eight times higher risk for having pathological RSI than NEG patients. Moreover, pathological RSI was associated with more severe ocular symptoms both in DED and non-DED patients. The role of LPR in definite DED pa…
View article: The ocular microbiome and microbiota and their effects on ocular surface pathophysiology and disorders
The ocular microbiome and microbiota and their effects on ocular surface pathophysiology and disorders Open
View article: Tear <sup>1</sup>H Nuclear Magnetic Resonance-Based Metabolomics Application to the Molecular Diagnosis of Aqueous Tear Deficiency and Meibomian Gland Dysfunction
Tear <sup>1</sup>H Nuclear Magnetic Resonance-Based Metabolomics Application to the Molecular Diagnosis of Aqueous Tear Deficiency and Meibomian Gland Dysfunction Open
Purpose: Meibomian gland dysfunction (MGD) is a major cause of signs and symptoms related to dry eyes (DE) and eyelid inflammation. We investigated the composition of human tears by metabolomic approaches in patients with aqu…
View article: Correction to: Heredity and in vivo confocal microscopy of punctiform and polychromatic pre-Descemet dystrophy
Correction to: Heredity and in vivo confocal microscopy of punctiform and polychromatic pre-Descemet dystrophy Open
View article: Reconsidering the central role of mucins in dry eye and ocular surface diseases
Reconsidering the central role of mucins in dry eye and ocular surface diseases Open
View article: Artificial tear with in situ gelling properties for the treatment of dry eye disease
Artificial tear with in situ gelling properties for the treatment of dry eye disease Open
View article: Can artificial tears prevent Acanthamoeba keratitis? An in vitro approach
Can artificial tears prevent Acanthamoeba keratitis? An in vitro approach Open
The present study uses, for the first time, CTC stain analyzed by flow cytometry to establish Acanthamoeba viability demonstrating its usefulness and complementarity with the traditional stain, Trypan Blue. Artelac® Splash, with no preserv…
View article: NEW REGENERATING AGENTS FOR OCULAR SURFACE: A NEUROTROPHIC KERATITIS CASE SERIES.
NEW REGENERATING AGENTS FOR OCULAR SURFACE: A NEUROTROPHIC KERATITIS CASE SERIES. Open
View article: Results of clinical trials with a novel RNA-based therapy (SYL1001) to treat patients with ocular pain associated to dry eye disease
Results of clinical trials with a novel RNA-based therapy (SYL1001) to treat patients with ocular pain associated to dry eye disease Open
View article: Treatment of Acanthamoeba neurotrophic corneal ulcer with topical matrix therapy
Treatment of Acanthamoeba neurotrophic corneal ulcer with topical matrix therapy Open