Jose Manuel Martinez Manzano
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View article: Association of Estimated Plasma Volume Status With Invasive Hemodynamics and Adverse Clinical Outcomes in Patients With Pulmonary Hypertension and Chronic Kidney Disease
Association of Estimated Plasma Volume Status With Invasive Hemodynamics and Adverse Clinical Outcomes in Patients With Pulmonary Hypertension and Chronic Kidney Disease Open
Identifying noninvasive measures to assess intravascular volume status and risk stratify patients with pulmonary hypertension (PH) and chronic kidney disease (CKD) is needed. We assessed the predictive value of estimated plasma volume stat…
View article: Association of Estimated Plasma Volume Status With Invasive Hemodynamics and All‐Cause Mortality in Patients With Liver Cirrhosis
Association of Estimated Plasma Volume Status With Invasive Hemodynamics and All‐Cause Mortality in Patients With Liver Cirrhosis Open
Background Estimated plasma volume status (ePVS) correlates with intravascular congestion and prognosis in patients with heart failure. The ePVS relationship with invasive hemodynamic profiling and clinical outcomes in patients with liver …
View article: Pulmonary vasodilators in patients with advanced chronic kidney disease and pre‐capillary pulmonary hypertension—A case series
Pulmonary vasodilators in patients with advanced chronic kidney disease and pre‐capillary pulmonary hypertension—A case series Open
Pulmonary hypertension (PH) is a prevalent complication among patients with chronic kidney disease (CKD). In these patients, pulmonary vasodilators may be useful but are underused. We describe a group of patients with precapillary PH and a…
View article: Shark fin sign: A rare <scp>EKG</scp> finding in a patient with Takotsubo cardiomyopathy from influenza A infection
Shark fin sign: A rare <span>EKG</span> finding in a patient with Takotsubo cardiomyopathy from influenza A infection Open
Key Clinical Message This case demonstrated the rare “shark fin” ECG pattern, an ST‐segment elevation typically seen in acute myocardial infarction. We reported a case of takotsubo cardiomyopathy secondary to influenza A infection with mul…
View article: Association of mildly elevated pulmonary vascular resistance with major cardiovascular events in pulmonary hypertension and chronic kidney disease: A retrospective cohort analysis
Association of mildly elevated pulmonary vascular resistance with major cardiovascular events in pulmonary hypertension and chronic kidney disease: A retrospective cohort analysis Open
Pulmonary hypertension (PH) is associated with adverse outcomes in chronic kidney disease (CKD) patients. Our study suggests mildly elevated pulmonary vascular resistance ( > 2 to ≤ 3) is independently associated with major adverse cardiov…
View article: A 72-year-old man with acute lung injury and anti-melanoma differentiation-associated gene 5 antibody: A case report
A 72-year-old man with acute lung injury and anti-melanoma differentiation-associated gene 5 antibody: A case report Open
View article: Radiologic imaging utilization in the diagnosis of acute pancreatitis
Radiologic imaging utilization in the diagnosis of acute pancreatitis Open
Background and objectives: Acute pancreatitis is a major cause of hospitalizations in the United States. Imaging is often unwarranted in early, uncomplicated pancreatitis however can prove to be useful in specific clinical scenarios. This …
View article: Focal Alveolar Hemorrhage Secondary to Hydralazine-Associated Antineutrophilic Cytoplasmic Antibody Vasculitis
Focal Alveolar Hemorrhage Secondary to Hydralazine-Associated Antineutrophilic Cytoplasmic Antibody Vasculitis Open
View article: Coronavirus disease-19 infection and angioedema in African Americans: A case series
Coronavirus disease-19 infection and angioedema in African Americans: A case series Open
View article: Brain MRI abnormalities in acute ethylene glycol poisoning: a case report
Brain MRI abnormalities in acute ethylene glycol poisoning: a case report Open
Ethylene glycol (EG) is a toxic alcohol that causes central nervous system depression and multiple metabolic abnormalities including a high anion gap metabolic acidosis (HAGMA), elevated osmolal gap (OG), and acute kidney injury. Few case …
View article: Psychological impact of genetic and clinical screening for pulmonary fibrosis on asymptomatic first-degree relatives of affected individuals
Psychological impact of genetic and clinical screening for pulmonary fibrosis on asymptomatic first-degree relatives of affected individuals Open
Screening for pulmonary fibrosis may help to identify early stages of the disease. We assessed the psychological impact of screening undiagnosed first-degree relatives of patients with pulmonary fibrosis by administering two validated meas…
View article: Single Cell RNA-seq and Mass Cytometry Reveals a Novel and a Targetable Population of Macrophages in Idiopathic Pulmonary Fibrosis
Single Cell RNA-seq and Mass Cytometry Reveals a Novel and a Targetable Population of Macrophages in Idiopathic Pulmonary Fibrosis Open
In this study, we leveraged a combination of single cell RNAseq, cytometry by time of flight (CyTOF), and flow cytometry to study the biology of a unique macrophage population in pulmonary fibrosis. Using the profiling data from 312,928 ce…
View article: A Tale of Two Proteolytic Machines: Matrix Metalloproteinases and the Ubiquitin–Proteasome System in Pulmonary Fibrosis
A Tale of Two Proteolytic Machines: Matrix Metalloproteinases and the Ubiquitin–Proteasome System in Pulmonary Fibrosis Open
Pulmonary fibrosis is a chronic and progressive lung disease characterized by the activation of fibroblasts and the irreversible deposition of connective tissue matrices that leads to altered pulmonary architecture and physiology. Multiple…
View article: Interstitial Lung Disease in Relatives of Patients with Pulmonary Fibrosis
Interstitial Lung Disease in Relatives of Patients with Pulmonary Fibrosis Open
Rationale: Although relatives of patients with familial pulmonary fibrosis (FPF) are at an increased risk for interstitial lung disease (ILD), the risk among relatives of sporadic idiopathic pulmonary fibrosis (IPF) is not known.…