José López‐Miranda
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View article: A Promising Biomarker for Predicting Cardiovascular Risk in Asymptomatic Familial Hypercholesterolemia Patients From The SAFEHEART Study
A Promising Biomarker for Predicting Cardiovascular Risk in Asymptomatic Familial Hypercholesterolemia Patients From The SAFEHEART Study Open
Background Familial hypercholesterolemia (FH) is an autosomal dominant disorder associated with a markedly increased risk of premature atherosclerotic cardiovascular disease (ASCVD). Genetic and molecular factors, including microRNAs (miRN…
View article: Longitudinal association of dietary spermidine with hepatic function indexes and cardiometabolic traits in older adults with metabolic syndrome
Longitudinal association of dietary spermidine with hepatic function indexes and cardiometabolic traits in older adults with metabolic syndrome Open
Purpose: Spermidine administration ameliorates hepatic steatosis and cardiometabolic dysfunction in animal models. However, evidence in humans remains limited. We aimed to explore the 1-year longitudinal associations between changes in die…
View article: Sex-differences in endotoxemia and trimethylamine N-oxide according to the diet and type 2 diabetes status in coronary heart disease patients: from the CORDIOPREV study
Sex-differences in endotoxemia and trimethylamine N-oxide according to the diet and type 2 diabetes status in coronary heart disease patients: from the CORDIOPREV study Open
Background Cardiovascular disease (CVD) develops in men earlier in life but CVD women have a higher risk of cardiovascular mortality than CVD men. In addition, co-occurrence with type 2 diabetes mellitus (T2DM) increases CVD risk. We aimed…
View article: Acute Type A Aortic Dissection Presenting as Ischemic Stroke: Case Report
Acute Type A Aortic Dissection Presenting as Ischemic Stroke: Case Report Open
View article: Association Between Oxidative–Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case–Control Study
Association Between Oxidative–Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case–Control Study Open
Aim: To assess oxidative–inflammatory biomarker prediction of incident CKD after 1-year follow-up in a population with overweight/obesity and metabolic syndrome. Methods: Prospective nested case–control study comprising 117 CKD incident ca…
View article: Incidence, clinical and genomic trends of hospital- and Non-hospital-onset KPC-producing Klebsiella pneumoniae infections before and during the COVID-19 era: a ten-year interrupted time series study
Incidence, clinical and genomic trends of hospital- and Non-hospital-onset KPC-producing Klebsiella pneumoniae infections before and during the COVID-19 era: a ten-year interrupted time series study Open
ASP and COVID-19 IPC measures contributed to maintaining low KPC-KP incidence. Genomic evidence underscores the role of temporal dynamics and clonal expansion in ST512/KPC-3 dissemination. Non-HOI infections are clinically significant and …
View article: Sex differences in (poly)phenol intake patterns and cardiovascular risk in Spanish adult population at high risk of cardiovascular disease: Cross-sectional findings
Sex differences in (poly)phenol intake patterns and cardiovascular risk in Spanish adult population at high risk of cardiovascular disease: Cross-sectional findings Open
The trial was registered at the International Standard Randomized Controlled Trial (ISRCTN89898870).
View article: Corrigendum to “Influence of gender and menopausal status on gut microbiota” [Maturitas Vol. 116 (2018) 43-53]
Corrigendum to “Influence of gender and menopausal status on gut microbiota” [Maturitas Vol. 116 (2018) 43-53] Open
View article: Corrigendum to Lipoprotein particle profile in the presence of peripheral artery disease among patients with coronary heart disease: Data from the CORDIOPREV study, Journal of Clinical Lipidology 19 (2025) 256–266
Corrigendum to Lipoprotein particle profile in the presence of peripheral artery disease among patients with coronary heart disease: Data from the CORDIOPREV study, Journal of Clinical Lipidology 19 (2025) 256–266 Open
View article: Dietary vitamin D intake and 2-year changes in cognitive function in older adults with overweight or obesity and metabolic syndrome
Dietary vitamin D intake and 2-year changes in cognitive function in older adults with overweight or obesity and metabolic syndrome Open
The protective role of dietary vitamin D intake on cognitive function is of interest, but evidence remains inconsistent. We aimed to evaluate the association between dietary vitamin D intake and 2-year cognitive changes in older adults at …
View article: Shotgun metagenomics data from faecal samples of 47 patients with mild cognitive impairment: Insights from the memoir study
Shotgun metagenomics data from faecal samples of 47 patients with mild cognitive impairment: Insights from the memoir study Open
This Data Note describes the MEMOIR dataset, consisting of shotgun metagenomics data from faecal samples of 47 individuals over the age of 65 diagnosed with mild cognitive impairment (MCI). The dataset was generated to investigate the rela…
View article: A microbiota pattern associated with cardiovascular events in secondary prevention: the CORDIOPREV study
A microbiota pattern associated with cardiovascular events in secondary prevention: the CORDIOPREV study Open
Background and Aims Preventing new cardiovascular events in patients with established cardiovascular disease (CVD) is a daunting task for clinicians. Intestinal microbiota may help identify patients at risk, thus improving the strategies o…
View article: Effect of long-term Mediterranean versus low-fat diet on neutrophil count, and type 2 diabetes mellitus remission in patients with coronary heart disease: results from the CORDIOPREV study
Effect of long-term Mediterranean versus low-fat diet on neutrophil count, and type 2 diabetes mellitus remission in patients with coronary heart disease: results from the CORDIOPREV study Open
View article: Cellular composition and transcriptomics of subcutaneous adipose tissue linked to blood glycated haemoglobin
Cellular composition and transcriptomics of subcutaneous adipose tissue linked to blood glycated haemoglobin Open
Objective Despite growing evidence, the mechanisms connecting adipose tissue (AT) function to type 2 diabetes (T2DM) remain incompletely understood. A detailed analysis of AT transcriptomes could offer valuable insights into this relations…
View article: MiRNAs as biomarkers of nutritional therapy to achieve T2DM remission in patients with coronary heart disease: from the CORDIOPREV study
MiRNAs as biomarkers of nutritional therapy to achieve T2DM remission in patients with coronary heart disease: from the CORDIOPREV study Open
View article: Deep Learning Model Approach to Predict Diabetes Type 2 Based on Clinical, Biochemical, and Gut Microbiota Profiles
Deep Learning Model Approach to Predict Diabetes Type 2 Based on Clinical, Biochemical, and Gut Microbiota Profiles Open
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease. Gut microbiota plays a key role in metabolic homeostasis and the development of T2DM and its complications. With the advance of artificial intelligence (AI), it is possible to…
View article: Gut Microbiota Interacts with Dietary Habits in Screenings for Early Detection of Colorectal Cancer
Gut Microbiota Interacts with Dietary Habits in Screenings for Early Detection of Colorectal Cancer Open
Background/Objectives: Gut microbiota interacts with nutrients, which may be relevant to assigning a microbial signature to colorectal cancer (CRC). We aim to evaluate the potential of gut microbiota combined with dietary habits in the ear…
View article: Dietary Lipid Quantity and Quality Modulate the Postprandial Metabolomic Profile in Patients with Metabolic Syndrome
Dietary Lipid Quantity and Quality Modulate the Postprandial Metabolomic Profile in Patients with Metabolic Syndrome Open
The literature on the postprandial metabolic changes in individuals with Metabolic Syndrome (MetS) remains limited, despite the fact that postprandial states represent the most common physiological condition in Western societies. Backgroun…
View article: Mediterranean diet, neutrophil count, and carotid intima-media thickness in secondary prevention: the CORDIOPREV study
Mediterranean diet, neutrophil count, and carotid intima-media thickness in secondary prevention: the CORDIOPREV study Open
Background and Aims Several studies have supported the role of innate immune system as a key factor in the sterile inflammation underlying the pathophysiology of atherosclerosis in mice. However, its involvement in humans remains unclear. …
View article: Differences in splicing factors may predict type 2 diabetes remission in the CORDIOPREV study
Differences in splicing factors may predict type 2 diabetes remission in the CORDIOPREV study Open
View article: DNA methylation and gene expression trajectories of human postprandial metabolism
DNA methylation and gene expression trajectories of human postprandial metabolism Open
Human postprandial metabolism is characterised by a highly individualised response to food that is predictive of cardiometabolic health and underexplored at the molecular level. We profiled blood DNA methylation (DNAm) and gene expression …
View article: Eficacia, beneficio y seguridad de inclisiran
Eficacia, beneficio y seguridad de inclisiran Open
Hypercholesterolemia is a causal factor of atherosclerotic cardiovascular disease (ASCVD), which is one of the main causes of morbidity and mortality in Spain. The reduction of LDL cholesterol (LDL-C) decreases the risk of ASCVD and advers…
View article: Modulation of circulating levels of advanced glycation end products and its impact on intima-media thickness of both common carotid arteries: CORDIOPREV randomised controlled trial
Modulation of circulating levels of advanced glycation end products and its impact on intima-media thickness of both common carotid arteries: CORDIOPREV randomised controlled trial Open
Our results suggest that an improvement in modulation of AGE metabolism, which facilitates better management of circulating AGE levels, may be one of the mechanisms through which the Mediterranean diet, compared to a low-fat diet, reduces …
View article: Multiomics of the intestine-liver-adipose axis in multiple studies unveils a consistent link of the gut microbiota and the antiviral response with systemic glucose metabolism
Multiomics of the intestine-liver-adipose axis in multiple studies unveils a consistent link of the gut microbiota and the antiviral response with systemic glucose metabolism Open
Background The microbiota is emerging as a key factor in the predisposition to insulin resistance and obesity. Objective To understand the interplay among gut microbiota and insulin sensitivity in multiple tissues. Design Integrative multi…
View article: Trimethylamine Oxidation into the Proatherogenic Trimethylamine N-Oxide Is Higher in Coronary Heart Disease Men: From the CORDIOPREV Study
Trimethylamine Oxidation into the Proatherogenic Trimethylamine N-Oxide Is Higher in Coronary Heart Disease Men: From the CORDIOPREV Study Open
Our results suggest that CHD men have augmented TMAO levels compared with CHD women, presumably as a consequence of higher rate of TMA to TMAO oxidation, which could be associated with CVD, as these sex differences are not observed in a no…
View article: Sex-specific dietary patterns and their association with metabolic syndrome: Insights from a cross-sectional analysis
Sex-specific dietary patterns and their association with metabolic syndrome: Insights from a cross-sectional analysis Open
View article: Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study
Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study Open
Background Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressi…
View article: Desired weight loss and its association with health, health behaviors and perceptions in an adult population with weight excess: One-year follow-up
Desired weight loss and its association with health, health behaviors and perceptions in an adult population with weight excess: One-year follow-up Open
Background: Metabolic syndrome (MetS) worsens quality of life and increases mortality. Dissatisfaction with weight in patients with MetS may modify the effect of lifestyle interventions to achieve changes in health-related…
View article: Mediterranean, DASH, and MIND Dietary Patterns and Cognitive Function: The 2-Year Longitudinal Changes in an Older Spanish Cohort
Mediterranean, DASH, and MIND Dietary Patterns and Cognitive Function: The 2-Year Longitudinal Changes in an Older Spanish Cohort Open
Background and Aims: Plant-forward dietary patterns have been associated with cardiometabolic health benefits, which, in turn, have been related to cognitive performance with inconsistent findings. The objective of this st…
View article: Desired weight loss and its association with health, health behaviors and perceptions in an adult population with weight excess: One-year follow-up
Desired weight loss and its association with health, health behaviors and perceptions in an adult population with weight excess: One-year follow-up Open
Background: Metabolic syndrome (MetS) worsens quality of life and increases mortality. Dissatisfaction with weight in patients with MetS may modify the effect of lifestyle interventions to achieve changes in health-related…