Jose O. Maximo
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View article: A Longitudinal Assessment of Anterior Cingulate Cortex Gamma-aminobutyric Acid in Antipsychotic Medication-naïve First Episode Psychosis Patients
A Longitudinal Assessment of Anterior Cingulate Cortex Gamma-aminobutyric Acid in Antipsychotic Medication-naïve First Episode Psychosis Patients Open
Background and Hypothesis Converging evidence from animal and human studies has implicated gamma-aminobutyric acid (GABA)-ergic dysfunction in the pathophysiology of psychosis spectrum disorders. However, little is known about GABA’s role …
View article: Early life stress and functional connectivity in antipsychotic-naïve first episode psychosis patients
Early life stress and functional connectivity in antipsychotic-naïve first episode psychosis patients Open
View article: Changes in glutamate levels in anterior cingulate cortex following 16 weeks of antipsychotic treatment in antipsychotic-naïve first-episode psychosis patients
Changes in glutamate levels in anterior cingulate cortex following 16 weeks of antipsychotic treatment in antipsychotic-naïve first-episode psychosis patients Open
Background Previous findings in psychosis have revealed mixed findings on glutamate (Glu) levels in the dorsal anterior cingulate cortex (dACC). Factors such as illness chronicity, methodology, and medication status have impeded a more nua…
View article: A longitudinal study of hippocampal subfield volumes and hippocampal glutamate levels in antipsychotic-naïve first episode psychosis patients
A longitudinal study of hippocampal subfield volumes and hippocampal glutamate levels in antipsychotic-naïve first episode psychosis patients Open
Background Previous studies have implicated hippocampal abnormalities in the neuropathology of psychosis spectrum disorders. Reduced hippocampal volume has been reported across all illness stages, and this atrophy has been hypothesized to …
View article: Dissecting Heterogeneity in Functional Network Connectivity Aberrations in Antipsychotic Medication-Naïve First Episode Psychosis Patients – A Normative Modeling Study
Dissecting Heterogeneity in Functional Network Connectivity Aberrations in Antipsychotic Medication-Naïve First Episode Psychosis Patients – A Normative Modeling Study Open
Importance While there is a general consensus that functional connectome pathology is a key mechanism underlying psychosis spectrum disorders, the literature is plagued with inconsistencies and translation into clinical practice is non-exi…
View article: Higher-order functional brain networks and anterior cingulate glutamate + glutamine (Glx) in antipsychotic-naïve first episode psychosis patients
Higher-order functional brain networks and anterior cingulate glutamate + glutamine (Glx) in antipsychotic-naïve first episode psychosis patients Open
Human connectome studies have provided abundant data consistent with the hypothesis that functional dysconnectivity is predominant in psychosis spectrum disorders. Converging lines of evidence also suggest an interaction between dorsal ant…
View article: Hippocampal Hyperconnectivity to the Visual Cortex Predicts Treatment Response
Hippocampal Hyperconnectivity to the Visual Cortex Predicts Treatment Response Open
Background Converging lines of evidence point to hippocampal dysfunction in psychosis spectrum disorders, including altered functional connectivity. Evidence also suggests that antipsychotic medications can modulate hippocampal dysfunction…
View article: Dorsal striatal hypoconnectivity predicts antipsychotic medication treatment response in first‐episode psychosis and unmedicated patients with schizophrenia
Dorsal striatal hypoconnectivity predicts antipsychotic medication treatment response in first‐episode psychosis and unmedicated patients with schizophrenia Open
Introduction The dorsal striatum, comprised of the caudate and putamen, is implicated in the pathophysiology of psychosis spectrum disorders. Given the high concentration of dopamine receptors in the striatum, striatal dopamine imbalance i…
View article: Contrasting Frontoparietal Network Connectivity in Antipsychotic Medication-Naive First-Episode Psychosis Patients Who Do and Do Not Display Features of the Deficit Syndrome
Contrasting Frontoparietal Network Connectivity in Antipsychotic Medication-Naive First-Episode Psychosis Patients Who Do and Do Not Display Features of the Deficit Syndrome Open
Background The deficit syndrome is a clinical subtype of schizophrenia that is characterized by enduring negative symptoms. Several lines of evidence point to frontoparietal involvement, but the frontoparietal control network (FPCN) and it…
View article: Structural and Functional Default Mode Network Connectivity and Antipsychotic Treatment Response in Medication-Naïve First Episode Psychosis Patients
Structural and Functional Default Mode Network Connectivity and Antipsychotic Treatment Response in Medication-Naïve First Episode Psychosis Patients Open
Introduction Only a few studies have comprehensively characterized default mode network (DMN) pathology on a structural and functional level, and definite conclusions cannot be drawn due to antipsychotic medication exposure and illness chr…
View article: Salience network glutamate and brain connectivity in medication-naïve first episode patients – A multimodal magnetic resonance spectroscopy and resting state functional connectivity MRI study
Salience network glutamate and brain connectivity in medication-naïve first episode patients – A multimodal magnetic resonance spectroscopy and resting state functional connectivity MRI study Open
View article: Hippocampal glutamate and hippocampus subfield volumes in antipsychotic-naive first episode psychosis subjects and relationships to duration of untreated psychosis
Hippocampal glutamate and hippocampus subfield volumes in antipsychotic-naive first episode psychosis subjects and relationships to duration of untreated psychosis Open
Evidence points toward a relationship between longer duration of untreated psychosis (DUP) and worse long-term outcomes in patients with first episode psychosis (FEP), but the underlying neurobiology remains poorly understood. Proton magne…
View article: Hippocampal Dysconnectivity and Altered Glutamatergic Modulation of the Default Mode Network: A Combined Resting-State Connectivity and Magnetic Resonance Spectroscopy Study in Schizophrenia
Hippocampal Dysconnectivity and Altered Glutamatergic Modulation of the Default Mode Network: A Combined Resting-State Connectivity and Magnetic Resonance Spectroscopy Study in Schizophrenia Open
View article: O2.2. EVALUATION OF THE RELATIONSHIP BETWEEN GLUTAMATE AND BRAIN CONNECTIVITY IN ANTIPSYCHOTIC-NAïVE FIRST EPISODE PATIENTS – A COMBINED MAGNETIC RESONANCE SPECTROSCOPY AND RESTING STATE FUNCTIONAL CONNECTIVITY MRI STUDY
O2.2. EVALUATION OF THE RELATIONSHIP BETWEEN GLUTAMATE AND BRAIN CONNECTIVITY IN ANTIPSYCHOTIC-NAïVE FIRST EPISODE PATIENTS – A COMBINED MAGNETIC RESONANCE SPECTROSCOPY AND RESTING STATE FUNCTIONAL CONNECTIVITY MRI STUDY Open
Background Schizophrenia is thought to be a disorder of brain dysconnectivity. An imbalance between cortical excitation/inhibition is also implicated, but the link between these abnormalities remains unclear. The present study used resting…
View article: S151. HIPPOCAMPAL CONNECTIVITY AND VOLUME AS PREDICTORS OF TREATMENT RESPONSE – A REPLICATION STUDY IN TWO PSYCHOSIS COHORTS
S151. HIPPOCAMPAL CONNECTIVITY AND VOLUME AS PREDICTORS OF TREATMENT RESPONSE – A REPLICATION STUDY IN TWO PSYCHOSIS COHORTS Open
Background Approximately 30% of patients with schizophrenia do not improve with antipsychotic drug (APD) treatment and 60% show sub-optimal response. Converging lines of evidence point to hippocampal dysfunction in schizophrenia. It is tho…
View article: Duration of Untreated Psychosis Correlates With Brain Connectivity and Morphology in Medication-Naïve Patients With First-Episode Psychosis
Duration of Untreated Psychosis Correlates With Brain Connectivity and Morphology in Medication-Naïve Patients With First-Episode Psychosis Open
View article: The role of mirroring and mentalizing networks in mediating action intentions in autism
The role of mirroring and mentalizing networks in mediating action intentions in autism Open
Background The ability to interpret agents’ intent from their actions is a vital skill in successful social interaction. However, individuals with autism spectrum disorders (ASD) have been found to have difficulty in attributing intentions…
View article: T89. LONGITUDINAL EVALUATION OF GLUTAMATE AND N-ACETYL-ASPARTATE IN ANTIPSYCHOTIC-NAïVE FIRST EPISODE PSYCHOSIS SUBJECTS AND RELATIONSHIPS TO DURATION OF UNTREATED PSYCHOSIS AND RESPONSE TO ANTIPSYCHOTIC MEDICATION
T89. LONGITUDINAL EVALUATION OF GLUTAMATE AND N-ACETYL-ASPARTATE IN ANTIPSYCHOTIC-NAïVE FIRST EPISODE PSYCHOSIS SUBJECTS AND RELATIONSHIPS TO DURATION OF UNTREATED PSYCHOSIS AND RESPONSE TO ANTIPSYCHOTIC MEDICATION Open
Meta-analyses have consistently identified a relationship between longer duration of untreated psychosis (DUP) and worse long-term outcomes in patients with schizophrenia. However, the neurobiology of this phenomenon and its implications f…
View article: S86. DURATION OF UNTREATED PSYCHOSIS CORRELATES WITH BRAIN CONNECTIVITY IN ANTIPSYCHOTIC-NAïVE PATIENTS WITH FIRST EPISODE PSYCHOSIS
S86. DURATION OF UNTREATED PSYCHOSIS CORRELATES WITH BRAIN CONNECTIVITY IN ANTIPSYCHOTIC-NAïVE PATIENTS WITH FIRST EPISODE PSYCHOSIS Open
The National Institute of Mental Health has deemed imperative to 1) fully understand the behavioral and brain mechanisms of individuals who experience first episode psychosis (FEP) and to 2) substantially reduce the duration of untreated p…
View article: A Longitudinal Multimodal Neuroimaging Study to Examine Relationships Between Resting State Glutamate and Task Related BOLD Response in Schizophrenia
A Longitudinal Multimodal Neuroimaging Study to Examine Relationships Between Resting State Glutamate and Task Related BOLD Response in Schizophrenia Open
Previous studies have observed impairments in both brain function and neurometabolite levels in schizophrenia. In this study, we investigated the relationship between brain activity and neurochemistry in off-medication patients with schizo…
View article: Action simulation and mirroring in children with autism spectrum disorders
Action simulation and mirroring in children with autism spectrum disorders Open
View article: From word reading to multisentence comprehension: Improvements in brain activity in children with autism after reading intervention
From word reading to multisentence comprehension: Improvements in brain activity in children with autism after reading intervention Open
View article: Network Organization Is Globally Atypical in Autism: A Graph Theory Study of Intrinsic Functional Connectivity
Network Organization Is Globally Atypical in Autism: A Graph Theory Study of Intrinsic Functional Connectivity Open
View article: Aberrant functioning of the theory-of-mind network in children and adolescents with autism
Aberrant functioning of the theory-of-mind network in children and adolescents with autism Open
Overall, the findings of this study reveal disruptions in the brain circuitry underlying ToM in ASD at multiple levels, including decreased activation and decreased functional connectivity.
View article: Changes in intrinsic connectivity of the brain's reading network following intervention in children with autism
Changes in intrinsic connectivity of the brain's reading network following intervention in children with autism Open
While task-based neuroimaging studies have identified alterations in neural circuitry underlying language processing in children with autism spectrum disorders [ASD], resting state functional magnetic resonance imaging [rsfMRI] is a promis…