José Pedro Sequeira
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View article: Methylation‐Specific Droplet Digital PCR: Testing a Novel Triage Tool for HrHPV‐Positive Women in the Cervical Cancer Screening Program of Northern Portugal
Methylation‐Specific Droplet Digital PCR: Testing a Novel Triage Tool for HrHPV‐Positive Women in the Cervical Cancer Screening Program of Northern Portugal Open
View article: Binary Superposition Algebra: A HyperComplex, Commutative, and Associative Product
Binary Superposition Algebra: A HyperComplex, Commutative, and Associative Product Open
In this article, we present a novel hyper-complex algebra grounded in a binary superposition algebras. We demonstrate this consistency through a structured binary formalism. This new product framework. Each algebraic element is represented…
View article: Improved recovery of urinary small extracellular vesicles by differential ultracentrifugation
Improved recovery of urinary small extracellular vesicles by differential ultracentrifugation Open
View article: Preliminary outcomes of the Cervical Cancer Screening Program of Northern Portugal: A snapshot
Preliminary outcomes of the Cervical Cancer Screening Program of Northern Portugal: A snapshot Open
Our study confirmed the reliability and effectiveness of first line HrHPV genotyping in the Cervical Cancer Screening Program of Northern Portugal. Nonetheless, it also raised concerns about excessive referral to colposcopy, with the inher…
View article: Biomarkers for Pre-Treatment Risk Stratification of Prostate Cancer Patients: A Systematic Review
Biomarkers for Pre-Treatment Risk Stratification of Prostate Cancer Patients: A Systematic Review Open
Background: Prostate cancer (PCa) is one of the most frequently occurring malignancies. Although most cases are not life-threatening, approximately 20% endure an unfavorable outcome. PSA-based screening reduced mortality but at the cost of…
View article: Urinary extracellular vesicles isolation: Improving the differential ultracentrifugation method for biomarker research
Urinary extracellular vesicles isolation: Improving the differential ultracentrifugation method for biomarker research Open
View article: OncoUroMiR: Circulating miRNAs for Detection and Discrimination of the Main Urological Cancers Using a ddPCR-Based Approach
OncoUroMiR: Circulating miRNAs for Detection and Discrimination of the Main Urological Cancers Using a ddPCR-Based Approach Open
The three most common genitourinary malignancies (prostate/kidney/bladder cancers) constitute a substantial proportion of all cancer cases, mainly in the elderly population. Early detection is key to maximizing the patients’ survival, but …
View article: DigiMir Test: Establishing a Novel Pipeline for MiR-371a Quantification Using Droplet Digital PCR in Liquid Biopsies From Testicular Germ Cell Tumor Patients
DigiMir Test: Establishing a Novel Pipeline for MiR-371a Quantification Using Droplet Digital PCR in Liquid Biopsies From Testicular Germ Cell Tumor Patients Open
Testicular germ cell tumors (TGCTs) are the most common cancers in young-adult male patients aged between 15 and 39 years. Hsa-miR-371a-3p is currently the most reliable biomarker for diagnosis and monitoring of these patients non-invasive…
View article: LiKidMiRs: A ddPCR-Based Panel of 4 Circulating miRNAs for Detection of Renal Cell Carcinoma
LiKidMiRs: A ddPCR-Based Panel of 4 Circulating miRNAs for Detection of Renal Cell Carcinoma Open
Background: Decreased renal cell cancer-related mortality is an important societal goal, embodied by efforts to develop effective biomarkers enabling early detection and increasing the likelihood of curative treatment. Herein, we sought to…
View article: Downregulation of m <sup>6</sup> A writer complex member METTL14 in bladder urothelial carcinoma suppresses tumor aggressiveness
Downregulation of m <sup>6</sup> A writer complex member METTL14 in bladder urothelial carcinoma suppresses tumor aggressiveness Open
N6‐methyladenosine (m 6 A) and its regulatory proteins have been associated with tumorigenesis in several cancer types. However, knowledge on the mechanistic network related to m 6 A in bladder cancer (BlCa) is rather limited, requiring fu…
View article: Prognostic Value of Histone Modifying Enzyme EZH2 in RCHOP-Treated Diffuse Large B-Cell Lymphoma and High Grade B-Cell Lymphoma
Prognostic Value of Histone Modifying Enzyme EZH2 in RCHOP-Treated Diffuse Large B-Cell Lymphoma and High Grade B-Cell Lymphoma Open
Background: DLBCL represent a heterogeneous group of aggressive diseases. High grade B-cell lymphomas (HGBCL) were recently individualized from DLBCL as a discrete diagnostic entity due to their worse prognosis. Currently, although most pa…
View article: Unveiling the World of Circulating and Exosomal microRNAs in Renal Cell Carcinoma
Unveiling the World of Circulating and Exosomal microRNAs in Renal Cell Carcinoma Open
Renal cell carcinoma is the third most common urological cancer. Despite recent advances, late diagnosis and poor prognosis of advanced-stage disease remain a major problem, entailing the need for novel early diagnosis tools. Liquid biopsi…
View article: Promoter methylation of DNA homologous recombination genes is predictive of the responsiveness to PARP inhibitor treatment in testicular germ cell tumors
Promoter methylation of DNA homologous recombination genes is predictive of the responsiveness to PARP inhibitor treatment in testicular germ cell tumors Open
Testicular germ cell tumors (TGCTs) are the most common cancers in men aged 15–39 years and are divided into two major groups, seminomas and nonseminomas. Novel treatment options are required for these patients, to limit side effects of ch…
View article: Plasma Extracellular Vesicle-Derived TIMP-1 mRNA as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma: A Pilot Study
Plasma Extracellular Vesicle-Derived TIMP-1 mRNA as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma: A Pilot Study Open
The tumor microenvironment has gained a lot of attention from the scientific community since it has a proven impact in the development of tumor progression and metastasis. Extracellular vesicles (EVs) are now considered one of the key play…
View article: Extracellular Vesicles Enriched in hsa-miR-301a-3p and hsa-miR-1293 Dynamics in Clear Cell Renal Cell Carcinoma Patients: Potential Biomarkers of Metastatic Disease
Extracellular Vesicles Enriched in hsa-miR-301a-3p and hsa-miR-1293 Dynamics in Clear Cell Renal Cell Carcinoma Patients: Potential Biomarkers of Metastatic Disease Open
Clear cell renal cell carcinoma (ccRCC) is the most aggressive subtype of kidney cancer and up to 40% of patients submitted to surgery with a curative intent will relapse. Thus, the aim of this study was to analyze the applicability of an …