José Román Escudero
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View article: Differential Expression Analyses on Human Aortic Tissue Reveal Novel Genes and Pathways Associated With Abdominal Aortic Aneurysm Onset and Progression
Differential Expression Analyses on Human Aortic Tissue Reveal Novel Genes and Pathways Associated With Abdominal Aortic Aneurysm Onset and Progression Open
Background Abdominal aortic aneurysms (AAAs) are focal dilatations of the abdominal aorta that expand progressively, increasing their risk of rupture. Rupture of an AAA is associated with high mortality rates, but the mechanisms underlying…
View article: Differential expression analyses on aortic tissue reveal novel genes and pathways associated with abdominal aortic aneurysm onset and progression
Differential expression analyses on aortic tissue reveal novel genes and pathways associated with abdominal aortic aneurysm onset and progression Open
Background Abdominal aortic aneurysms (AAA) are focal dilatations of the abdominal aorta. They are normally asymptomatic and progressively expand, increasing their risk of rupture. Rupture of an AAA is associated with high mortality rates,…
View article: Differential Expression Analyses on Aortic Tissue reveal Novel Genes and Pathways Associated with Abdominal Aortic Aneurysm Onset and Progression
Differential Expression Analyses on Aortic Tissue reveal Novel Genes and Pathways Associated with Abdominal Aortic Aneurysm Onset and Progression Open
Background: Abdominal aortic aneurysms (AAA) are focal dilatations of the abdominal aorta. They are normally asymptomatic and expand progressively, increasing their risk of rupture. Rupture of an AAA is associated with high mortality rates…
View article: Targeting Tyrosine Hydroxylase for Abdominal Aortic Aneurysm: Impact on Inflammation, Oxidative Stress, and Vascular Remodeling
Targeting Tyrosine Hydroxylase for Abdominal Aortic Aneurysm: Impact on Inflammation, Oxidative Stress, and Vascular Remodeling Open
Pharmacological treatments for preventing abdominal aortic aneurysm (AAA) rupture or slowing aneurysm progression remain a challenge. It is increasingly recognized that sympathetic activity might play a role in the pathogenesis of AAA; how…
View article: Cord blood-derived platelet concentrates as starting material for new therapeutic blood components prepared in a public cord blood bank: from product development to clinical application.
Cord blood-derived platelet concentrates as starting material for new therapeutic blood components prepared in a public cord blood bank: from product development to clinical application. Open
We designed and validated a highly reproducible, closed system method to manufacture high quality CBPC suitable for clinical applications using CB units not suitable for transplantation in a public CBB.
View article: The TAGA Study: A Study of Factors Determining Aortic Diameter in Families at High Risk of Abdominal Aortic Aneurysm Reveal Two New Candidate Genes
The TAGA Study: A Study of Factors Determining Aortic Diameter in Families at High Risk of Abdominal Aortic Aneurysm Reveal Two New Candidate Genes Open
A variety of disorders are known to be related with aortic geometry, among them abdominal aortic aneurysm (AAA). This work aims to present the main determinants of abdominal aortic diameter in a new cohort of families at high risk of AAA. …
View article: Enhanced endoplasmic reticulum and mitochondrial stress in abdominal aortic aneurysm
Enhanced endoplasmic reticulum and mitochondrial stress in abdominal aortic aneurysm Open
Abdominal aortic aneurysm (AAA) is a degenerative vascular disease with a complex aetiology that remains to be fully elucidated. Clinical management of AAA is limited to surgical repair, while an effective pharmacotherapy is still awaited.…
View article: <p>Variation in the choice of elective surgical procedure for abdominal aortic aneurysm in Spain</p>
Variation in the choice of elective surgical procedure for abdominal aortic aneurysm in Spain Open
This study reveals high variability in the surgical treatment of unruptured AAA across Spanish hospitals. The number of interventions has increased in recent years, with EVAR accounting for a growing percentage of these surgical procedures…
View article: Anemia en pacientes sometidos a cirugía vascular, factor predictor de amputación y muerte
Anemia en pacientes sometidos a cirugía vascular, factor predictor de amputación y muerte Open
View article: Circulating CCL20 as a New Biomarker of Abdominal Aortic Aneurysm
Circulating CCL20 as a New Biomarker of Abdominal Aortic Aneurysm Open
View article: Increased Peak Wall Stress, but Not Maximum Diameter, Is Associated with Symptomatic Abdominal Aortic Aneurysm
Increased Peak Wall Stress, but Not Maximum Diameter, Is Associated with Symptomatic Abdominal Aortic Aneurysm Open
View article: Down-regulation of Fibulin-5 is associated with aortic dilation: role of inflammation and epigenetics
Down-regulation of Fibulin-5 is associated with aortic dilation: role of inflammation and epigenetics Open
We evidence the deregulation of FBLN5 in human AAA and identify a SOX9/HDAC-dependent mechanism involved in the down-regulation of FBLN5 by inflammation. HDAC inhibitors or pharmacological approaches that aimed to preserve FBLN5 could be u…
View article: Clinical guidelines for the prevention, diagnosis and treatment of venous thromboembolism in sport
Clinical guidelines for the prevention, diagnosis and treatment of venous thromboembolism in sport Open
The term venous thromboembolism refers to various pathological processes among which deep vein thrombosis, pulmonary embolism, chronic thromboembolic pulmonary hypertension and the thrombotic syndrome. The importance in sports activities i…