Josè Starvaggi
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View article: Microwave-Assisted Organic Synthesis: An Eco-Friendly Method of Green Chemistry
Microwave-Assisted Organic Synthesis: An Eco-Friendly Method of Green Chemistry Open
The name Green Chemistry was coined in 1996 to point out the development of chemical substances and sustainable processes that reduce the formation of toxic products for the environment and humans. The urgent need to bring down the negativ…
View article: Microwave-Assisted Organic Synthesis: An Eco-Friendly Method of Green Chemistry
Microwave-Assisted Organic Synthesis: An Eco-Friendly Method of Green Chemistry Open
The name Green Chemistry was coined in 1996 to point out the development of chemical substances and sustainable processes that reduce the formation of toxic products for the environment and humans. The urgent need to bring down the negativ…
View article: The Role of Nutraceuticals in Age-Related Ocular Diseases
The Role of Nutraceuticals in Age-Related Ocular Diseases Open
Although conventional medicine has seen substantial progress in recent years, there is a growing interest in nutraceuticals, bioactive compounds derived from natural sources such as plants, fruits, and cereals, due to their potential thera…
View article: Synthesis and Combination Studies of Novel Dipeptide Nitriles with Curcumin for a Potent Synergistic Action Against Rhodesain, Cysteine Protease of Trypanosoma brucei rhodesiense
Synthesis and Combination Studies of Novel Dipeptide Nitriles with Curcumin for a Potent Synergistic Action Against Rhodesain, Cysteine Protease of Trypanosoma brucei rhodesiense Open
Background/Objectives: Rhodesain is a cysteine protease crucial for the life cycle of Trypanosoma brucei rhodesiense, a parasite that causes the lethal form of human African trypanosomiasis. For these reasons, rhodesain is considered an im…
View article: Drug Combination Studies of Isoquinolinone AM12 with Curcumin or Quercetin: A New Combination Strategy to Synergistically Inhibit 20S Proteasome
Drug Combination Studies of Isoquinolinone AM12 with Curcumin or Quercetin: A New Combination Strategy to Synergistically Inhibit 20S Proteasome Open
In the eukaryotic cells, the ubiquitin–proteasome system (UPS) plays a crucial role in the intracellular protein turnover. It is involved in several cellular functions such as the control of the regular cell cycle progression, the immune s…
View article: Development of Novel Peptidyl Nitriles Targeting Rhodesain and Falcipain-2 for the Treatment of Sleeping Sickness and Malaria
Development of Novel Peptidyl Nitriles Targeting Rhodesain and Falcipain-2 for the Treatment of Sleeping Sickness and Malaria Open
In recent decades, neglected tropical diseases and poverty-related diseases have become a serious health problem worldwide. Among these pathologies, human African trypanosomiasis, and malaria present therapeutic problems due to the onset o…
View article: The Inhibition of NS2B/NS3 Protease: A New Therapeutic Opportunity to Treat Dengue and Zika Virus Infection
The Inhibition of NS2B/NS3 Protease: A New Therapeutic Opportunity to Treat Dengue and Zika Virus Infection Open
In the global pandemic scenario, dengue and zika viruses (DENV and ZIKV, respectively), both mosquito-borne members of the flaviviridae family, represent a serious health problem, and considering the absence of specific antiviral drugs and…