José Trincão
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View article: Multicrystal data collection at the VMXm beamline at Diamond Light Source
Multicrystal data collection at the VMXm beamline at Diamond Light Source Open
Determining the structure of a protein is essential for understanding its function. However, X-ray crystallography becomes increasingly difficult as the diffracting power of crystals decreases with a decrease in crystal size. This challeng…
View article: A comparison of an electron diffraction and an X-ray diffraction experiment from a single protein microcrystal lamella
A comparison of an electron diffraction and an X-ray diffraction experiment from a single protein microcrystal lamella Open
X-ray diffraction (XRD) of microcrystals is signal-to-noise limited by the inherently weak diffraction. As such, Electron diffraction (ED) is increasingly used to measure diffraction data from submicron crystals, or those deemed too small …
View article: VMXm – A sub-micron focus macromolecular crystallography beamline at Diamond Light Source
VMXm – A sub-micron focus macromolecular crystallography beamline at Diamond Light Source Open
VMXm joins the suite of operational macromolecular crystallography beamlines at Diamond Light Source. It has been designed to optimize rotation data collections from protein crystals less than 10 µm and down to below 1 µm in size. The beam…
View article: CCDC 968640: Experimental Crystal Structure Determination
CCDC 968640: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 968641: Experimental Crystal Structure Determination
CCDC 968641: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 968645: Experimental Crystal Structure Determination
CCDC 968645: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 968642: Experimental Crystal Structure Determination
CCDC 968642: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 968647: Experimental Crystal Structure Determination
CCDC 968647: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 968648: Experimental Crystal Structure Determination
CCDC 968648: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 968654: Experimental Crystal Structure Determination
CCDC 968654: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 968649: Experimental Crystal Structure Determination
CCDC 968649: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 968638: Experimental Crystal Structure Determination
CCDC 968638: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 968637: Experimental Crystal Structure Determination
CCDC 968637: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 968651: Experimental Crystal Structure Determination
CCDC 968651: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 968653: Experimental Crystal Structure Determination
CCDC 968653: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 968644: Experimental Crystal Structure Determination
CCDC 968644: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 968639: Experimental Crystal Structure Determination
CCDC 968639: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 968646: Experimental Crystal Structure Determination
CCDC 968646: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 968643: Experimental Crystal Structure Determination
CCDC 968643: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 968652: Experimental Crystal Structure Determination
CCDC 968652: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 968650: Experimental Crystal Structure Determination
CCDC 968650: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine Open
Nirmatrelvir (PF-07321332) is a nitrile-bearing small-molecule inhibitor that, in combination with ritonavir, is used to treat infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Nirmatrelvir interrupts the viral li…
View article: A Sample Preparation Pipeline for Microcrystals at the VMXm Beamline
A Sample Preparation Pipeline for Microcrystals at the VMXm Beamline Open
The mounting of microcrystals (1 . Further improvements in data quality will be gained through improvements in sample environment and sample preparation. Microcrystals inherently generate weaker diffraction, therefore improving the signal-…
View article: Scanning electron microscopy as a method for sample visualization in protein X-ray crystallography
Scanning electron microscopy as a method for sample visualization in protein X-ray crystallography Open
Developing methods to determine high-resolution structures from micrometre- or even submicrometre-sized protein crystals has become increasingly important in recent years. This applies to both large protein complexes and membrane proteins,…
View article: Optical elements for dynamically broadening the focus of micro-focus optics at synchrotron x-ray sources
Optical elements for dynamically broadening the focus of micro-focus optics at synchrotron x-ray sources Open
Third generation synchrotron radiation sources offer the possibility of using high demagnification ratio optics to achieve a micro-focused X-ray beam profile of size less than one micrometre size. This is highly advantageous for a variety …