Josef Anrather
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View article: Gut microbiota promote immune tolerance at the maternal-fetal interface 3952
Gut microbiota promote immune tolerance at the maternal-fetal interface 3952 Open
Description Immune tolerance at the maternal-fetal interface is required for fetal development. Excessive maternal interferon gamma (IFNγ) and interleukin-17 (IL-17) responses is linked to adverse effects on fetal growth, but the regulatio…
View article: Neutrophil stalling does not mediate the increase in tau phosphorylation and the cognitive impairment associated with high salt diet
Neutrophil stalling does not mediate the increase in tau phosphorylation and the cognitive impairment associated with high salt diet Open
Aims High dietary salt intake has powerful effects on cerebral blood vessels and has emerged as a risk factor for stroke and cognitive impairment. In mice, a high salt diet (HSD) leads to reduced cerebral blood flow (CBF), tau hyperphospho…
View article: Assessing post-stroke cognition in pre-clinical models: lessons and recommendations from a multi-center study
Assessing post-stroke cognition in pre-clinical models: lessons and recommendations from a multi-center study Open
Cognitive decline is a significant long-term consequence of stroke and has no available treatments. To aid in therapy development, we sought to achieve robust detection of cognitive performance after stroke in a multi-site design. Ischemic…
View article: Hypertension-Induced Neurovascular and Cognitive Dysfunction at Single-Cell Resolution
Hypertension-Induced Neurovascular and Cognitive Dysfunction at Single-Cell Resolution Open
Arterial hypertension is a leading cause of cognitive impairment, attributed to cerebrovascular insufficiency, blood-brain barrier disruption, and white matter damage. However, the molecular mechanisms by which hypertension affects brain c…
View article: Neutrophil stalling does not mediate the increase in tau phosphorylation and the cognitive impairment associated with high salt diet
Neutrophil stalling does not mediate the increase in tau phosphorylation and the cognitive impairment associated with high salt diet Open
High dietary salt intake has powerful effects on cerebral blood vessels and has emerged as a risk factor for stroke and cognitive impairment. In mice, high salt diet (HSD) leads to reduced cerebral blood flow (CBF), tau hyperphosphorylatio…
View article: Molecular and Functional Alterations in the Cerebral Microvasculature in an Optimized Mouse Model of Sepsis-Associated Cognitive Dysfunction
Molecular and Functional Alterations in the Cerebral Microvasculature in an Optimized Mouse Model of Sepsis-Associated Cognitive Dysfunction Open
Systemic inflammation has been implicated in the development and progression of neurodegenerative conditions such as cognitive impairment and dementia. Recent clinical studies indicate an association between sepsis, endothelial dysfunction…
View article: A minimally invasive thrombotic stroke model to study circadian rhythm in awake mice
A minimally invasive thrombotic stroke model to study circadian rhythm in awake mice Open
Experimental stroke models in rodents are essential for mechanistic studies and therapeutic development. However, these models have several limitations negatively impacting their translational relevance. Here we aimed to develop a minimall…
View article: Molecular and functional alterations in the cerebral microvasculature in an optimized mouse model of sepsis-associated cognitive dysfunction
Molecular and functional alterations in the cerebral microvasculature in an optimized mouse model of sepsis-associated cognitive dysfunction Open
Systemic inflammation has been implicated in the development and progression of neurodegenerative conditions such as cognitive impairment and dementia. Recent clinical studies indicate an association between sepsis, endothelial dysfunction…
View article: Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress Open
Background Cerebral amyloid angiopathy (CAA) is a devastating condition common in patients with Alzheimer’s disease but also observed in the general population. Vascular oxidative stress and neurovascular dysfunction have been implicated i…
View article: Comparative multi-omic analyses of cardiac mitochondrial stress in three mouse models of frataxin deficiency
Comparative multi-omic analyses of cardiac mitochondrial stress in three mouse models of frataxin deficiency Open
Cardiomyopathy is often fatal in Friedreich ataxia (FA). However, FA hearts maintain adequate function until advanced disease stages, suggesting initial adaptation to the loss of frataxin (FXN). Conditional cardiac knockout mouse models of…
View article: Calcium transients in nNOS neurons underlie distinct phases of the neurovascular response to barrel cortex activation in awake mice
Calcium transients in nNOS neurons underlie distinct phases of the neurovascular response to barrel cortex activation in awake mice Open
Neuronal nitric oxide (NO) synthase (nNOS), a Ca 2+ dependent enzyme, is expressed by distinct populations of neocortical neurons. Although neuronal NO is well known to contribute to the blood flow increase evoked by neural activity, the r…
View article: Immune compartments at the brain’s borders in health and neurovascular diseases
Immune compartments at the brain’s borders in health and neurovascular diseases Open
Recent evidence implicates cranial border immune compartments in the meninges, choroid plexus, circumventricular organs, and skull bone marrow in several neuroinflammatory and neoplastic diseases. Their pathogenic importance has also been …
View article: Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress Open
Background: Cerebral amyloid angiopathy (CAA) is a devastating condition common in patients with Alzheimer’s disease but also observed in the general population. Vascular oxidative stress and neurovascular dysfunction have been implicated …
View article: Brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke
Brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke Open
Summary Cerebral ischemia triggers a powerful inflammatory reaction involving both peripheral leukocytes and brain resident cells. Recent evidence indicates that their differentiation into a variety of functional phenotypes contributes to …
View article: The Neurovasculome: Key Roles in Brain Health and Cognitive Impairment: A Scientific Statement From the American Heart Association/American Stroke Association
The Neurovasculome: Key Roles in Brain Health and Cognitive Impairment: A Scientific Statement From the American Heart Association/American Stroke Association Open
Background: Preservation of brain health has emerged as a leading public health priority for the aging world population. Advances in neurovascular biology have revealed an intricate relationship among brain cells, meninges, and the hematic…
View article: A preclinical randomized controlled multi-centre trial of anti-interleukin-17A treatment for acute ischaemic stroke
A preclinical randomized controlled multi-centre trial of anti-interleukin-17A treatment for acute ischaemic stroke Open
Multiple consensus statements have called for preclinical randomized controlled trials to improve translation in stroke research. We investigated the efficacy of an interleukin-17A neutralizing antibody in a multi-centre preclinical random…
View article: Comparative multi-omics analyses of cardiac mitochondrial stress in three mouse models of frataxin deficiency
Comparative multi-omics analyses of cardiac mitochondrial stress in three mouse models of frataxin deficiency Open
Cardiomyopathy is often fatal in Friedreich Ataxia (FA). However, the FA heart maintains adequate function until disease end stage, suggesting that it can initially adapt to the loss of frataxin (FXN). Conditional knockout mouse models wit…
View article: DNA damage independent inhibition of NF-κB transcription by anthracyclines
DNA damage independent inhibition of NF-κB transcription by anthracyclines Open
Anthracyclines are among the most used and effective anticancer drugs. Their activity has been attributed to DNA double-strand breaks resulting from topoisomerase II poisoning and to eviction of histones from select sites in the genome. He…
View article: Calcium transients in nNOS neurons underlie distinct phases of the neurovascular response to barrel cortex activation in awake mice
Calcium transients in nNOS neurons underlie distinct phases of the neurovascular response to barrel cortex activation in awake mice Open
Neuronal nitric oxide (NO) synthase (nNOS), a Ca 2+ dependent enzyme, is expressed by distinct populations of neocortical neurons. Although neuronal NO is well known to contribute to the blood flow increase evoked by neural activity, the r…
View article: A preclinical randomized multicenter trial of anti-IL-17A treatment for acute ischemic stroke
A preclinical randomized multicenter trial of anti-IL-17A treatment for acute ischemic stroke Open
Multiple consensus statements have called for preclinical randomized controlled trials (pRCT) to improve translation in stroke research. Here, we investigated the efficacy of IL-17A neutralizing antibodies in a multicentric pRCT using a mu…