Explanipedia

Aging-linked systemic lipid signature is reprogrammed by caloric restriction in rhesus monkeys Open

Salma I Abou Elhassan, Josef P. Clark, Di Kuang, Timothy W. Rhoads, Ricki J. Colman , et al. · 2025

Caloric restriction (CR) without malnutrition delays aging in diverse species, including primates, with metabolic changes implicated in this process. To facilitate exploration of CR metabolism with aging, we developed a 15-minute LC-MS/MS …

Caloric Restriction Reprograms Adipose Tissues in Rhesus Monkeys Open

Josef P. Clark, Timothy W. Rhoads, Sean J. McIlwain, Michael A. Polewski, Derek M. Pavelec , et al. · 2025

Caloric restriction (CR) is a dietary intervention that delays the onset of age‐related diseases and enhances survival in diverse organisms, and although changes in adipose tissues have been implicated in the beneficial effects of CR, the …

Metformin suppresses the mitochondrial and transcriptional response to exercise, revealing a conserved BCL6B-associated angiogenic program Open

Matthew D. Bruss, Christian J. Elliehausen, Josef P. Clark, Dennis M. Minton, Adam R. Konopka · 2025

Metformin inhibited skeletal muscle mitochondrial respiration and transcriptional adaptations to aerobic exercise training. The findings from this study suggest BCL6B as a conserved exercise-responsive transcription factor in mice and huma…

Caloric restriction reprograms adipose tissues in rhesus monkeys Open

Josef P. Clark, Timothy W. Rhoads, Sean J. McIlwain, Michael A. Polewski, Derek M. Pavelec , et al. · 2025

Caloric restriction (CR) is a dietary intervention that delays the onset of age-related diseases and enhances survival in diverse organisms, and although changes in adipose tissues have been implicated in the beneficial effects of CR the m…

Neuron-specific isoform of PGC-1α regulates neuronal metabolism and brain aging Open

Dylan C. Souder, Eric R. McGregor, Josef P. Clark, Timothy W. Rhoads, Tiaira J. Porter , et al. · 2025

The brain is a high-energy tissue, and although aging is associated with dysfunctional inflammatory and neuron-specific functional pathways, a direct connection to metabolism is not established. Here, we show that isoforms of mitochondrial…

Reversal of neuronal tau pathology via adiponectin receptor activation Open

Eric R. McGregor, Danny J. Lasky, Olivia J. Rippentrop, Josef P. Clark, Samantha Wright , et al. · 2025

Reversal of neuronal tau pathology, metabolic dysfunction, and electrophysiological defects via adiponectin pathway-dependent AMPK activation Open

Eric R. McGregor, Danny J. Lasky, Olivia J. Rippentrop, Josef P. Clark, Samantha Wright , et al. · 2024

Changes in brain mitochondrial metabolism are coincident with functional decline; however, direct links between the two have not been established. Here, we show that mitochondrial targeting via the adiponectin receptor activator AdipoRon (…

Mitochondrial regulator PGC-1a in neuronal metabolism and brain aging Open

Dylan C. Souder, Eric R. McGregor, Timothy W. Rhoads, Josef P. Clark, Tiaira J. Porter , et al. · 2023

The brain is a high energy tissue, and the cell types of which it is comprised are distinct in function and in metabolic requirements. The transcriptional co-activator PGC-1a is a master regulator of mitochondrial function and is highly ex…

Molecular and Functional Networks Linked to Sarcopenia Prevention by Caloric Restriction in Rhesus Monkeys Open

Timothy W. Rhoads, Josef P. Clark, Grace E. Gustafson, Karl N. Miller, Matthew W. Conklin , et al. · 2020

PGC‐1a integrates a metabolism and growth network linked to caloric restriction Open

Karl N. Miller, Josef P. Clark, Stephen A. Martin, Porsha R. Howell, Maggie S. Burhans , et al. · 2019

Deleterious changes in energy metabolism have been linked to aging and disease vulnerability, while activation of mitochondrial pathways has been linked to delayed aging by caloric restriction (CR). The basis for these associations is poor…

GSK3β Regulates Brain Energy Metabolism Open

Stephen A. Martin, Dylan C. Souder, Karl N. Miller, Josef P. Clark, Md Abdul Kader Sagar , et al. · 2018

Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys Open

Timothy W. Rhoads, Maggie S. Burhans, Vincent B. Chen, Paul D. Hutchins, Matthew J. P. Rush , et al. · 2018

Drosophila PAF1 Modulates PIWI/piRNA Silencing Capacity Open

Josef P. Clark, Reazur Rahman, Nachen Yang, Linda H. Yang, Nelson C. Lau · 2017

Caloric restriction impacts plasma micro<span>RNA</span>s in rhesus monkeys Open

Augusto Schneider, Joseph Dhahbi, Hani Atamna, Josef P. Clark, Ricki J. Colman , et al. · 2017

Summary Caloric restriction ( CR ) is one of the most robust interventions shown to delay aging in diverse species, including rhesus monkeys ( Macaca mulatta ). Identification of factors involved in CR brings a promise of translatability t…

Aging and caloric restriction impact adipose tissue, adiponectin, and circulating lipids Open

Karl N. Miller, Maggie S. Burhans, Josef P. Clark, Porsha R. Howell, Michael A. Polewski , et al. · 2017

Adipose tissue expansion has been associated with system-wide metabolic dysfunction and increased vulnerability to diabetes, cancer, and cardiovascular disease. A reduction in adiposity is a hallmark of caloric restriction (CR), an interve…

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