Josef Pfeilschifter
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View article: Christian Bauer—physiologist, mentor, and philosopher
Christian Bauer—physiologist, mentor, and philosopher Open
View article: Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF
Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF Open
Heart failure with preserved ejection fraction (HFpEF) presents significant treatment challenges. We assessed hydrogen sulfide (H2S) bioavailability in HFpEF patients and 2 animal models: the "2-hit" L-NAME + high-fat diet mouse…
View article: Estrogen receptor β stimulation as a possible novel therapeutic target for cutaneous T-cell lymphoma
Estrogen receptor β stimulation as a possible novel therapeutic target for cutaneous T-cell lymphoma Open
Cutaneous T-cell lymphomas (CTCLs), including mycosis fungoides (MF) and Sézary syndrome (SS), are rare hematological malignancies with limited curative treatment options. Despite early-stage responsiveness, these malignancies often relaps…
View article: The XCL1/XCR1 axis is upregulated in type 1 diabetes and aggravates its pathogenesis
The XCL1/XCR1 axis is upregulated in type 1 diabetes and aggravates its pathogenesis Open
Type 1 diabetes (T1D) is precipitated by the autoimmune destruction of the insulin-producing β cells in the pancreatic islets of Langerhans. Chemokines have been identified as major conductors of islet infiltration by autoaggressive leukoc…
View article: TRIM25: A Global Player of Cell Death Pathways and Promising Target of Tumor-Sensitizing Therapies
TRIM25: A Global Player of Cell Death Pathways and Promising Target of Tumor-Sensitizing Therapies Open
Therapy resistance still constitutes a common hurdle in the treatment of many human cancers and is a major reason for treatment failure and patient relapse, concomitantly with a dismal prognosis. In addition to “intrinsic resistance”, e.g.…
View article: Lipid signaling: facets of a versatile cell communication strategy in health and disease
Lipid signaling: facets of a versatile cell communication strategy in health and disease Open
View article: A role for plasma membrane Ca2+ ATPases in regulation of cellular Ca2+ homeostasis by sphingosine kinase-1
A role for plasma membrane Ca2+ ATPases in regulation of cellular Ca2+ homeostasis by sphingosine kinase-1 Open
View article: The contribution of the sphingosine 1-phosphate signaling pathway to chronic kidney diseases: recent findings and new perspectives
The contribution of the sphingosine 1-phosphate signaling pathway to chronic kidney diseases: recent findings and new perspectives Open
Chronic kidney disease (CKD) is a multifactorial condition with diverse etiologies, such as diabetes mellitus, hypertension, and genetic disorders, often culminating in end-stage renal disease (ESRD). A hallmark of CKD progression is kidne…
View article: Enhanced photodynamic therapy of curcumin using biodegradable PLGA coated mesoporous silica nanoparticles
Enhanced photodynamic therapy of curcumin using biodegradable PLGA coated mesoporous silica nanoparticles Open
View article: Atypical sphingosine-1-phosphate metabolites—biological implications of alkyl chain length
Atypical sphingosine-1-phosphate metabolites—biological implications of alkyl chain length Open
Sphingosine-1-phosphate (S1P) is a bioactive lipid signaling molecule with pleiotropic implications by both auto- and paracrine signaling. Signaling occurs by engaging five G protein-coupled receptors (S1P 1-5 ) or intracellular pathways. …
View article: Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF: Evidence for Synergistic Benefit with GLP-1/Glucagon Agonism
Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF: Evidence for Synergistic Benefit with GLP-1/Glucagon Agonism Open
Background Heart failure with preserved ejection fraction (HFpEF) is a significant public health concern with limited treatment options. Dysregulated nitric oxide-mediated signaling has been implicated in HFpEF pathophysiology, however, li…
View article: Blockade of neutrophil extracellular trap components ameliorates cholestatic liver disease in Mdr2 (Abcb4) knockout mice
Blockade of neutrophil extracellular trap components ameliorates cholestatic liver disease in Mdr2 (Abcb4) knockout mice Open
Primary sclerosing cholangitis (PSC) is an (auto)immune-mediated cholestatic liver disease with a yet unclear etiology. Increasing evidence points to an involvement of neutrophils in chronic liver inflammation and cirrhosis but also liver …
View article: Tribute to Andrea Huwiler (1966–2023)
Tribute to Andrea Huwiler (1966–2023) Open
View article: Cross-Regulation of the Cellular Redox System, Oxygen, and Sphingolipid Signalling
Cross-Regulation of the Cellular Redox System, Oxygen, and Sphingolipid Signalling Open
Redox-active mediators are now appreciated as powerful molecules to regulate cellular dynamics such as viability, proliferation, migration, cell contraction, and relaxation, as well as gene expression under physiological and pathophysiolog…
View article: Loss of S1P Lyase Expression in Human Podocytes Causes a Reduction in Nephrin Expression That Involves PKCδ Activation
Loss of S1P Lyase Expression in Human Podocytes Causes a Reduction in Nephrin Expression That Involves PKCδ Activation Open
Sphingosine 1-phosphate (S1P) lyase (SPL, Sgpl1) is an ER-associated enzyme that irreversibly degrades the bioactive lipid, S1P, and thereby regulates multiple cellular functions attributed to S1P. Biallelic mutations in the human Sglp1 ge…
View article: Expression of PKM2 in wound keratinocytes is coupled to angiogenesis during skin repair in vivo and in HaCaT keratinocytes in vitro
Expression of PKM2 in wound keratinocytes is coupled to angiogenesis during skin repair in vivo and in HaCaT keratinocytes in vitro Open
View article: The E3 Ligase TRIM25 Impairs Apoptotic Cell Death in Colon Carcinoma Cells via Destabilization of Caspase-7 mRNA: A Possible Role of hnRNPH1
The E3 Ligase TRIM25 Impairs Apoptotic Cell Death in Colon Carcinoma Cells via Destabilization of Caspase-7 mRNA: A Possible Role of hnRNPH1 Open
Therapy resistance is still a major reason for treatment failure in colorectal cancer (CRC). Previously, we identified the E3 ubiquitin ligase TRIM25 as a novel suppressor of caspase-2 translation which contributes to the apoptosis resista…
View article: Hydrogen Sulfide Modulates Endothelial–Mesenchymal Transition in Heart Failure
Hydrogen Sulfide Modulates Endothelial–Mesenchymal Transition in Heart Failure Open
Background: Hydrogen sulfide is a critical endogenous signaling molecule that exerts protective effects in the setting of heart failure. Cystathionine γ-lyase (CSE), 1 of 3 hydrogen-sulfide–producing enzyme, is predominantly localized in t…
View article: Differential expression of CD8 defines phenotypically distinct cytotoxic T cells in cancer and multiple sclerosis
Differential expression of CD8 defines phenotypically distinct cytotoxic T cells in cancer and multiple sclerosis Open
Background Cytotoxic T lymphocytes take on a leading role in many immune‐related diseases. They function as key effector immune cells fighting cancer cells, but they are also considerably involved in autoimmune diseases. Common to both sit…
View article: Reciprocal abrogation of <scp>PKM</scp> isoforms: contradictory outcomes and differing impact of splicing signal on <scp>CRISPR</scp> /Cas9 mediates gene editing in keratinocytes
Reciprocal abrogation of <span>PKM</span> isoforms: contradictory outcomes and differing impact of splicing signal on <span>CRISPR</span> /Cas9 mediates gene editing in keratinocytes Open
The healing of wounded skin is a highly organized process involving a massive cell in‐ and outflux, proliferation and tissue remodelling. It is well accepted that metabolic constraints such as diabetes mellitus, overweight or anorexia impa…
View article: Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells
Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells Open
Erythropoietin (Epo) is a crucial hormone regulating red blood cell number and consequently the hematocrit. Epo is mainly produced in the kidney by interstitial fibroblast-like cells. Previously, we have shown that in cultures of the immor…
View article: The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions
The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions Open
Caspase-2 represents an evolutionary conserved caspase, which plays a role in genotoxic stress-induced apoptosis, ageing-related metabolic changes, and in deleting aneuploid cells in tumors. Genetic deletion of caspase-2 leads to increased…
View article: Impact of Moderna mRNA-1273 Booster Vaccine on Fully Vaccinated High-Risk Chronic Dialysis Patients after Loss of Humoral Response
Impact of Moderna mRNA-1273 Booster Vaccine on Fully Vaccinated High-Risk Chronic Dialysis Patients after Loss of Humoral Response Open
The long-term effect of protection by two doses of SARS-CoV-2 vaccination in patients receiving chronic intermittent hemodialysis (CIHD) is an urging question. We investigated the humoral and cellular immune response of 42 CIHD patients wh…
View article: Sphingosine 1-Phosphate Receptor 5 (S1P5) Knockout Ameliorates Adenine-Induced Nephropathy
Sphingosine 1-Phosphate Receptor 5 (S1P5) Knockout Ameliorates Adenine-Induced Nephropathy Open
S1P and its receptors have been reported to play important roles in the development of renal fibrosis. Although S1P5 has barely been investigated so far, there are indications that it can influence inflammatory and fibrotic processes. Here…
View article: The atypical sphingosine 1‐phosphate variant, d16:1 S1P, mediates CTGF induction via S1P2 activation in renal cell carcinoma
The atypical sphingosine 1‐phosphate variant, d16:1 S1P, mediates CTGF induction via S1P2 activation in renal cell carcinoma Open
Sphingosine 1‐phosphate (S1P) is a lipid mediator with numerous biological functions. The term ‘S1P’ mainly refers to the sphingolipid molecule with a long‐chain sphingoid base of 18 carbon atoms, d18:1 S1P. The enzyme serine palmitoyltran…
View article: The Pathophysiology of H2S in Renal Glomerular Diseases
The Pathophysiology of H2S in Renal Glomerular Diseases Open
Renal glomerular diseases such as glomerulosclerosis and diabetic nephropathy often result in the loss of glomerular function and consequently end-stage renal disease. The glomerulus consists of endothelial cells, mesangial cells and glome…
View article: Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile
Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile Open
Sphingosine 1 phosphate (S1P) lyase (Sgpl1) catalyses the irreversible cleavage of S1P and thereby the last step of sphingolipid degradation. Loss of Sgpl1 in humans and mice leads to accumulation of sphingolipids and multiple organ injuri…
View article: Application of pseudotyped virus particles to monitor Ebola virus and SARS-CoV-2 viral entry in human cell lines
Application of pseudotyped virus particles to monitor Ebola virus and SARS-CoV-2 viral entry in human cell lines Open
View article: Enhanced CXCR4 Expression of Human CD8Low T Lymphocytes Is Driven by S1P4
Enhanced CXCR4 Expression of Human CD8Low T Lymphocytes Is Driven by S1P4 Open
Although the human immune response to cancer is naturally potent, it can be severely disrupted as a result of an immunosuppressive tumor microenvironment. Infiltrating regulatory T lymphocytes contribute to this immunosuppression by inhibi…
View article: Recuperation of Vascular Homeostasis
Recuperation of Vascular Homeostasis Open