Josef Šulc
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View article: Continuous cell-type diversification in mouse visual cortex development
Continuous cell-type diversification in mouse visual cortex development Open
View article: Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice
Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice Open
View article: Continuous cell type diversification throughout the embryonic and postnatal mouse visual cortex development
Continuous cell type diversification throughout the embryonic and postnatal mouse visual cortex development Open
The mammalian cortex is composed of a highly diverse set of cell types and develops through a series of temporally regulated events that build out the cell type and circuit foundation for cortical function. The mechanisms underlying the de…
View article: A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain Open
View article: Connecting single-cell transcriptomes to projectomes in mouse visual cortex
Connecting single-cell transcriptomes to projectomes in mouse visual cortex Open
The mammalian brain is composed of diverse neuron types that play different functional roles. Recent single-cell RNA sequencing approaches have led to a whole brain taxonomy of transcriptomically-defined cell types, yet cell type definitio…
View article: Transcriptomic cytoarchitecture reveals principles of human neocortex organization
Transcriptomic cytoarchitecture reveals principles of human neocortex organization Open
Variation in cytoarchitecture is the basis for the histological definition of cortical areas. We used single cell transcriptomics and performed cellular characterization of the human cortex to better understand cortical areal specializatio…
View article: Interindividual variation in human cortical cell type abundance and expression
Interindividual variation in human cortical cell type abundance and expression Open
Single-cell transcriptomic studies have identified a conserved set of neocortical cell types from small postmortem cohorts. We extended these efforts by assessing cell type variation across 75 adult individuals undergoing epilepsy and tumo…
View article: INTER-INDIVIDUAL VARIATION IN HUMAN CORTICAL CELL TYPE ABUNDANCE AND EXPRESSION
INTER-INDIVIDUAL VARIATION IN HUMAN CORTICAL CELL TYPE ABUNDANCE AND EXPRESSION Open
View article: Protein interaction network analysis of mTOR signaling reveals modular organization
Protein interaction network analysis of mTOR signaling reveals modular organization Open
The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that acts as a central mediator of translation and plays important roles in cell growth, synaptic plasticity, cancer, and a wide range of developmental disorders. The si…
View article: Protein interaction network analysis of mTOR signaling reveals modular organization
Protein interaction network analysis of mTOR signaling reveals modular organization Open
The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that acts as a central mediator of translation, and plays important roles in cell growth, synaptic plasticity, cancer, and a wide range of developmental disorders. The s…
View article: Cell-type specific molecular signatures of aging revealed in a brain-wide transcriptomic cell-type atlas
Cell-type specific molecular signatures of aging revealed in a brain-wide transcriptomic cell-type atlas Open
Biological aging can be defined as a gradual loss of homeostasis across various aspects of molecular and cellular function. Aging is a complex and dynamic process which influences distinct cell types in a myriad of ways. The cellular archi…
View article: A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain Open
The mammalian brain is composed of millions to billions of cells that are organized into numerous cell types with specific spatial distribution patterns and structural and functional properties. An essential step towards understanding brai…
View article: Transcriptomic cytoarchitecture reveals principles of human neocortex organization
Transcriptomic cytoarchitecture reveals principles of human neocortex organization Open
Variation in cortical cytoarchitecture is the basis for histology-based definition of cortical areas, such as Brodmann areas. Single cell transcriptomics enables higher-resolution characterization of cell types in human cortex, which we us…
View article: Inter-individual variation in human cortical cell type abundance and expression
Inter-individual variation in human cortical cell type abundance and expression Open
Single cell transcriptomic studies have identified a conserved set of neocortical cell types from small post-mortem cohorts. We extend these efforts by assessing cell type variation across 75 adult individuals undergoing epilepsy and tumor…
View article: Author Correction: Comparative cellular analysis of motor cortex in human, marmoset and mouse
Author Correction: Comparative cellular analysis of motor cortex in human, marmoset and mouse Open
View article: Local connectivity and synaptic dynamics in mouse and human neocortex
Local connectivity and synaptic dynamics in mouse and human neocortex Open
We present a unique, extensive, and open synaptic physiology analysis platform and dataset. Through its application, we reveal principles that relate cell type to synaptic properties and intralaminar circuit organization in the mouse and h…
View article: Author Correction: Human neocortical expansion involves glutamatergic neuron diversification
Author Correction: Human neocortical expansion involves glutamatergic neuron diversification Open
View article: Additional file 1 of Sex differences in sucrose reinforcement in Long-Evans rats
Additional file 1 of Sex differences in sucrose reinforcement in Long-Evans rats Open
Additional file 1: Additional data from Experiments 4 and 5 including body weight corrected operant sucrose intake data.
View article: Profiling PI3K-AKT-MTOR variants in focal brain malformations reveals new insights for diagnostic care
Profiling PI3K-AKT-MTOR variants in focal brain malformations reveals new insights for diagnostic care Open
Focal malformations of cortical development including focal cortical dysplasia, hemimegalencephaly and megalencephaly, are a spectrum of neurodevelopmental disorders associated with brain overgrowth, cellular and architectural dysplasia, i…
View article: A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex
A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex Open
View article: Human neocortical expansion involves glutamatergic neuron diversification
Human neocortical expansion involves glutamatergic neuron diversification Open
View article: A multimodal cell census and atlas of the mammalian primary motor cortex
A multimodal cell census and atlas of the mammalian primary motor cortex Open
Here we report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of …
View article: Comparative cellular analysis of motor cortex in human, marmoset and mouse
Comparative cellular analysis of motor cortex in human, marmoset and mouse Open
View article: Submitted as a Research Report to Biology of Sex Differences
Submitted as a Research Report to Biology of Sex Differences Open
Background: There are sex differences in addiction behaviors. To develop a pre-clinical animal model to investigate this, the present study examined sex differences in sucrose taking and seeking using LongEvans rats. Methods: Five experime…
View article: Analysis of common PI3K-AKT-MTOR mutations in pediatric surgical epilepsy by droplet digital PCR reveals novel clinical and molecular insights
Analysis of common PI3K-AKT-MTOR mutations in pediatric surgical epilepsy by droplet digital PCR reveals novel clinical and molecular insights Open
Focal malformations of cortical development (FMCD) including focal cortical dysplasia (FCD), hemimegalencephaly (HMEG) and megalencephaly (MEG), constitute a spectrum of neurodevelopmental disorders associated with brain overgrowth, cellul…
View article: A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation
A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation Open
View article: Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells
Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells Open
View article: Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neurons
Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neurons Open
The neocortex is disproportionately expanded in human compared to mouse, both in its total volume relative to subcortical structures and in the proportion occupied by supragranular layers that selectively make connections within the cortex…
View article: Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse
Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse Open
The primary motor cortex (M1) is essential for voluntary fine motor control and is functionally conserved across mammals. Using high-throughput transcriptomic and epigenomic profiling of over 450,000 single nuclei in human, marmoset monkey…
View article: A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation
A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation Open
SUMMARY The isocortex and hippocampal formation are two major structures in the mammalian brain that play critical roles in perception, cognition, emotion and learning. Both structures contain multiple regions, for many of which the cellul…