Josefa León
YOU?
Author Swipe
View article: MON-277 Confirmatory Diagnosis of Primary Hyperaldosteronism Using Intravenous Saline Loading Test and Bilateral Adrenal Venous Sampling With ACTH Stimulation in a Patient With Low Aldosterone Renin Ratio (ARR)
MON-277 Confirmatory Diagnosis of Primary Hyperaldosteronism Using Intravenous Saline Loading Test and Bilateral Adrenal Venous Sampling With ACTH Stimulation in a Patient With Low Aldosterone Renin Ratio (ARR) Open
Disclosure: J.P. de Leon: None. M.G. Famorcan: None. J.Z. Lacson: None. F.C. Yap: None. L.B. Mercado-Asis: None. Background: Primary aldosteronism (PA), is an endocrine disorder characterized by excessive aldosterone production leading to …
View article: SAT-462 Usefulness of Confirmatory Saline Loading Test in Diagnosing Primary Hyperaldosteronism among Patients Suspected for Cyclical or Periodic Excess Aldosterone Secretion
SAT-462 Usefulness of Confirmatory Saline Loading Test in Diagnosing Primary Hyperaldosteronism among Patients Suspected for Cyclical or Periodic Excess Aldosterone Secretion Open
Disclosure: M.G. Famorcan: None. J.P. de Leon: None. F.C. Yap: None. J.Z. Lacson: None. J.V. Chua: None. J.L. Reyes: None. J.G. Sazon: None. J.F. Robles: None. L.B. Mercado-Asis: None. Background: Primary aldosteronism (PA) is responsible …
View article: Regulation of Stemness by NR1D2 in Colorectal Cancer
Regulation of Stemness by NR1D2 in Colorectal Cancer Open
Background: Nuclear Receptor Subfamily 1 Group D Member 2 (NR1D2), a transcription factor that regulates the circadian clock, has been described as an oncogene in colorectal cancer (CRC). In several types of cancer, NR1D2 regulates cancer …
View article: New insights into the integrative effects of resistance training at moderate altitude on systemic inflammation
New insights into the integrative effects of resistance training at moderate altitude on systemic inflammation Open
Purpose To determine the effect of intermittent terrestrial hypobaric hypoxia (HH) exposure on stress and inflammatory biomarkers following a resistance training (R T ) program. Methods Twenty trained males completed an 8-week R T program …
View article: Efficacy of <scp>HA130</scp> Hemoadsorption in Removing Advanced Glycation End Products in Maintenance Hemodialysis Patients
Efficacy of <span>HA130</span> Hemoadsorption in Removing Advanced Glycation End Products in Maintenance Hemodialysis Patients Open
Background Patients on maintenance hemodialysis (HD) face complications due to the accumulation of protein‐bound uremic toxins, such as advanced glycation end products (AGEs), which contribute to inflammation, oxidative stress, and cardiov…
View article: iNOS-Produced Nitric Oxide from Cancer Cells as an Intermediate of Stemness Regulation by PARP-1 in Colorectal Cancer
iNOS-Produced Nitric Oxide from Cancer Cells as an Intermediate of Stemness Regulation by PARP-1 in Colorectal Cancer Open
PARP-1 has been linked to the progression of several types of cancer. We have recently reported that PARP-1 influences tumor progression in CRC through the regulation of CSCs in a p53-dependent manner. In this study, we propose that nitric…
View article: Integrating Genomic Data into Public Health Surveillance for Multidrug-Resistant Organisms, Washington, USA
Integrating Genomic Data into Public Health Surveillance for Multidrug-Resistant Organisms, Washington, USA Open
Mitigating antimicrobial resistance (AMR) is a public health priority to preserve antimicrobial treatment options. The Washington State Department of Health in Washington, USA, piloted a process to leverage longitudinal genomic surveillanc…
View article: “I Pink I Can” Breast Cancer Intervention Program: Its Effectiveness in Raising Knowledge among Junior High School Students of San Pablo City Integrated High School
“I Pink I Can” Breast Cancer Intervention Program: Its Effectiveness in Raising Knowledge among Junior High School Students of San Pablo City Integrated High School Open
As incidence rates rise from one in ten women to one in eight by 2023, breast cancer continues to be a serious worldwide health concern. Regardless of its rarity in men, this study included men in addition to women who frequently get breas…
View article: Exploring the Impact of Resistance Training at Moderate Altitude on Metabolic Cytokines in Humans: Implications for Adipose Tissue Dynamics
Exploring the Impact of Resistance Training at Moderate Altitude on Metabolic Cytokines in Humans: Implications for Adipose Tissue Dynamics Open
Hypobaric hypoxia (HH) limits oxygen supply to tissues and increases metabolic demands, especially during exercise. We studied the influence of HH exposure on the subcutaneous adipose tissue (SAT) thickness and circulating metabolic-relate…
View article: Eosinophils in Colorectal Cancer: Emerging Insights into Anti-Tumoral Mechanisms and Clinical Implications
Eosinophils in Colorectal Cancer: Emerging Insights into Anti-Tumoral Mechanisms and Clinical Implications Open
Eosinophils are myeloid effector cells whose main homing is the gastrointestinal tract. There, they take part in type I and type II immune responses. They also contribute to other non-immunological homeostatic functions like mucus producti…
View article: Serum Phthalate Concentrations and Biomarkers of Oxidative Stress in Adipose Tissue in a Spanish Adult Cohort
Serum Phthalate Concentrations and Biomarkers of Oxidative Stress in Adipose Tissue in a Spanish Adult Cohort Open
The relationship between phthalates, a group of chemical pollutants classified as endocrine disruptors, and oxidative stress is not fully understood. The aim of the present hospital-based study was to explore the associations between circu…
View article: Environmental Exposure to Persistent Organic Pollutants and Its Association with Endometriosis Risk: Implications in the Epithelial–Mesenchymal Transition Process
Environmental Exposure to Persistent Organic Pollutants and Its Association with Endometriosis Risk: Implications in the Epithelial–Mesenchymal Transition Process Open
We aimed to explore the relationship of adipose tissue concentrations of some persistent organic pollutants (POPs) with the risk of endometriosis and the endometriotic tissue expression profile of genes related to the endometriosis-related…
View article: Expression Profiles of Genes Related to Development and Progression of Endometriosis and Their Association with Paraben and Benzophenone Exposure
Expression Profiles of Genes Related to Development and Progression of Endometriosis and Their Association with Paraben and Benzophenone Exposure Open
Increasing evidence has been published over recent years on the implication of endocrine-disrupting chemicals (EDCs), including parabens and benzophenones in the pathogenesis and pathophysiology of endometriosis. However, to the best of ou…
View article: Human adipose tissue as a major reservoir of cytomegalovirus-reactive T cells
Human adipose tissue as a major reservoir of cytomegalovirus-reactive T cells Open
Introduction Cytomegalovirus (CMV) is a common herpesvirus with a high prevalence worldwide. After the acute infection phase, CMV can remain latent in several tissues. CD8 T cells in the lungs and salivary glands mainly control its reactiv…
View article: Effect of a resistance exercise at acute moderate altitude on muscle health biomarkers
Effect of a resistance exercise at acute moderate altitude on muscle health biomarkers Open
The intensification of the stress response during resistance training (R T ) under hypoxia conditions could trigger unwanted effects that compromise muscle health and, therefore, the ability of the muscle to adapt to longer training period…
View article: β-Conglutins’ Unique Mobile Arm Is a Key Structural Domain Involved in Molecular Nutraceutical Properties of Narrow-Leafed Lupin (Lupinus angustifolius L.)
β-Conglutins’ Unique Mobile Arm Is a Key Structural Domain Involved in Molecular Nutraceutical Properties of Narrow-Leafed Lupin (Lupinus angustifolius L.) Open
Narrow-leafed lupin (NLL; Lupinus angustifolius L.) has multiple nutraceutical properties that may result from unique structural features of β-conglutin proteins, such as the mobile arm at the N-terminal, a structural domain rich in α-heli…
View article: Agomelatine, a Melatonin-Derived Drug, as a New Strategy for the Treatment of Colorectal Cancer
Agomelatine, a Melatonin-Derived Drug, as a New Strategy for the Treatment of Colorectal Cancer Open
The potential use of agomelatine as an alternative treatment for colorectal cancer is evaluated in this work. The effect of agomelatine was studied in an in vitro model using two cell lines with different p53 statuses (HCT-116, wild-type p…
View article: Cell cycle, apoptosis, cell differentiation, and lipid metabolism gene expression in endometriotic tissue and exposure to parabens and benzophenones
Cell cycle, apoptosis, cell differentiation, and lipid metabolism gene expression in endometriotic tissue and exposure to parabens and benzophenones Open
Our findings suggest that women exposure to cosmetic and PCP-released chemicals might be associated with the promotion of cell cycle and cell differentiation as well as with lipid metabolism disruption in endometriotic tissue, three crucia…
View article: PARP-1 Expression Influences Cancer Stem Cell Phenotype in Colorectal Cancer Depending on p53
PARP-1 Expression Influences Cancer Stem Cell Phenotype in Colorectal Cancer Depending on p53 Open
Poly(ADP-ribose) polymerase-1 (PARP-1) is a protein involved in multiple physiological processes. Elevated PARP-1 expression has been found in several tumours, being associated with stemness and tumorigenesis. In colorectal cancer (CRC), s…
View article: Narrow Leafed Lupin (Lupinus angustifolius L.) β-Conglutin Seed Proteins as a New Natural Cytotoxic Agents against Breast Cancer Cells
Narrow Leafed Lupin (Lupinus angustifolius L.) β-Conglutin Seed Proteins as a New Natural Cytotoxic Agents against Breast Cancer Cells Open
Breast cancer (BC) is the most widespread tumor in women and the second type of most common cancer worldwide. Despite all the technical and medical advances in existing therapies, between 30 and 50% of patients with BC will develop metasta…
View article: Associations of circulating levels of phthalate metabolites with cytokines and acute phase reactants in a Spanish human cohort
Associations of circulating levels of phthalate metabolites with cytokines and acute phase reactants in a Spanish human cohort Open
The associations between human phthalate exposure and the onset of chronic diseases with an immunological component (e.g., metabolic syndrome, cancer) remain unclear, partly due to the uncertainties in the underlying mechanisms. This study…
View article: In Obese Patients With Type 2 Diabetes, Mast Cells in Omental Adipose Tissue Decrease the Surface Expression of CD45, CD117, CD203c, and FcϵRI
In Obese Patients With Type 2 Diabetes, Mast Cells in Omental Adipose Tissue Decrease the Surface Expression of CD45, CD117, CD203c, and FcϵRI Open
The paradigm of mast cells in type 2 diabetes is changing. Although they were first considered deleterious inflammatory cells, now they seem to be important players driving adipose tissue homeostasis. Here we have employed a flow cytometry…
View article: Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal Cancer
Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal Cancer Open
Colorectal cancer (CRC) is one of the most common tumours in developed countries. Although its incidence and mortality rates have decreased, its prognosis has not changed, and a high percentage of patients with CRC develop relapse (metachr…
View article: Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer
Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer Open
We aimed to assess the relationships among the adipose tissue's (AT) oxidative microenvironment, in situ accumulated persistent organic pollutant (POP) concentrations, and cancer development. POP and oxidative stress levels were quantified…
View article: Endothelin-1 as a Mediator of Heme Oxygenase-1-Induced Stemness in Colorectal Cancer: Influence of p53
Endothelin-1 as a Mediator of Heme Oxygenase-1-Induced Stemness in Colorectal Cancer: Influence of p53 Open
Heme oxygenase-1 (HO-1) is an antioxidant protein implicated in tumor progression, metastasis, and resistance to therapy. Elevated HO-1 expression is associated with stemness in several types of cancer, although this aspect has not yet bee…
View article: In Patients With Obesity, the Number of Adipose Tissue Mast Cells Is Significantly Lower in Subjects With Type 2 Diabetes
In Patients With Obesity, the Number of Adipose Tissue Mast Cells Is Significantly Lower in Subjects With Type 2 Diabetes Open
Type 2 diabetes (T2D) is a rising global health problem mainly caused by obesity and a sedentary lifestyle. In healthy individuals, white adipose tissue (WAT) has a relevant homeostatic role in glucose metabolism, energy storage, and endoc…
View article: Current Advances Research in Nutraceutical Compounds of Legumes, Pseudocereals and Cereals
Current Advances Research in Nutraceutical Compounds of Legumes, Pseudocereals and Cereals Open
The increase of the Western-type diet and life-style, with high content of highly processed fats, salt and sugar, as well as sedentary life, is directly linked to an increasing incidence of chronic diseases such as diabetes and obesity, ca…
View article: Hormonal and Inflammatory Responses to Hypertrophy-Oriented Resistance Training at Acute Moderate Altitude
Hormonal and Inflammatory Responses to Hypertrophy-Oriented Resistance Training at Acute Moderate Altitude Open
This study investigated the effect of a traditional hypertrophy-oriented resistance training (RT) session at acute terrestrial hypoxia on inflammatory, hormonal, and the expression of miR-378 responses associated with muscular gains. In a …