Josefa Macuada
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View article: <i>OPA1</i>and disease-causing mutants perturb mitochondrial nucleoid distribution
<i>OPA1</i>and disease-causing mutants perturb mitochondrial nucleoid distribution Open
Optic atrophy protein 1 (OPA1) mediates inner mitochondrial membrane (IMM) fusion and cristae organization. Mutations in OPA1 cause autosomal dominant optic atrophy (ADOA), a leading cause of blindness. Cells from ADOA patients show impair…
View article: <i>OPA1</i> disease-causing mutants have domain-specific effects on mitochondrial ultrastructure and fusion
<i>OPA1</i> disease-causing mutants have domain-specific effects on mitochondrial ultrastructure and fusion Open
Inner mitochondrial membrane fusion and cristae shape depend on optic atrophy protein 1, OPA1. Mutations in OPA1 lead to autosomal dominant optic atrophy (ADOA), an important cause of inherited blindness. The Guanosin Triphosphatase (GTPas…
View article: OPA1 Modulates Mitochondrial Ca2+ Uptake Through ER-Mitochondria Coupling
OPA1 Modulates Mitochondrial Ca2+ Uptake Through ER-Mitochondria Coupling Open
Autosomal Dominant Optic Atrophy (ADOA), a disease that causes blindness and other neurological disorders, is linked to OPA1 mutations. OPA1, dependent on its GTPase and GED domains, governs inner mitochondrial membrane (IMM) fusion and cr…