Josefin Kenrick
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View article: A human pan-disease blood atlas of the circulating proteome
A human pan-disease blood atlas of the circulating proteome Open
The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. In this study, we present a pan-disease resource to enable the study of diverse disease phenotypes within a …
View article: Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease
Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease Open
Preclinical efficacy and safety data in mice provide support for ex vivo β-globin gene correction to treat patients with sickle cell disease.
View article: Ku70 suppresses alternative end joining in G1-arrested progenitor B cells
Ku70 suppresses alternative end joining in G1-arrested progenitor B cells Open
Significance Alternative end joining (A-EJ) is implicated in oncogenic translocations and mediating DNA double-strand-break (DSB) repair in cycling cells when classical nonhomologous end-joining (C-NHEJ) factors of the C-NHEJ ligase comple…
View article: Ku70 suppresses alternative end-joining in G1-arrested progenitor B cells
Ku70 suppresses alternative end-joining in G1-arrested progenitor B cells Open
Classical nonhomologous end-joining (C-NHEJ) repairs DNA double-stranded breaks (DSBs) throughout interphase but predominates in G1-phase when homologous recombination is unavailable. Complexes containing the Ku70/80 (“Ku”) and XRCC4/Ligas…
View article: Expanding the editable genome and CRISPR–Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking
Expanding the editable genome and CRISPR–Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking Open
Genome editing typically involves recombination between donor nucleic acids and acceptor genomic sequences subjected to double-stranded DNA breaks (DSBs) made by programmable nucleases (e.g. CRISPR–Cas9). Yet, nucleases yield off-target mu…