Joseph A. Anuka
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View article: oxicological effects of artemether-nevirapine coadministration on serum biochemistry and some organs of Wistar rats
oxicological effects of artemether-nevirapine coadministration on serum biochemistry and some organs of Wistar rats Open
This study investigated toxicological effects of 5 and/or 10 mg/kg artemether (ART5 or ART10) and nevirapine (NVP) co-administration on serum biochemistry and some organs of Wistar rats. Drugs were administered intraperitoneally to 6 group…
View article: MODULATORY EFFECT OF PENTAZOCINE AND PETHIDINE ON ANTICONVULSANT ACTIVITY OF PHENOBARBITONE IN 4-AMINOPYRIDINE-INDUCED SEIZURES IN MICE
MODULATORY EFFECT OF PENTAZOCINE AND PETHIDINE ON ANTICONVULSANT ACTIVITY OF PHENOBARBITONE IN 4-AMINOPYRIDINE-INDUCED SEIZURES IN MICE Open
Management of epilepsy involved the use of many drugs, which sometimes include analgesics. Opioid analgesics being the second most commonly used drugs in insured epileptic patients are associated with neuro-excitation, ranging from nystagm…
View article: Dichloro-substituted phenyl amino propanamides exhibit anticonvulsant effect and reduce inward sodium ion current (Na<sub>V</sub>1.6)
Dichloro-substituted phenyl amino propanamides exhibit anticonvulsant effect and reduce inward sodium ion current (Na<sub>V</sub>1.6) Open
This research studied the anticonvulsant properties of three synthesized isomers of dichloro-substituted phenyl amino propanamides in rodents and determined their effects on votage-gated sodium channels (NaV1.6) stably expressed in Human E…
View article: Analgesic and Anti-inflammatory Activities of the Ethylacetate Extract of Mitracarpus villosus Leaves in Rodents
Analgesic and Anti-inflammatory Activities of the Ethylacetate Extract of Mitracarpus villosus Leaves in Rodents Open
Aims:To investigate the effects of the ethylacetate extract of Mitracarpus villosus leaves using various in-vivo models of pain, inflammation and pyrexia.Study Design: This study was designed to investigate the possible analgesic, anti-inf…