Joseph A. Prinz
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View article: Genomic variance in Yucatan pigs and detection of donor-derived cell-free DNA after heart transplantation
Genomic variance in Yucatan pigs and detection of donor-derived cell-free DNA after heart transplantation Open
Acute rejection, one of the most devastating complications that can occur following organ transplantation, is caused by antigenic differences between the organ donor and the recipient. Following cardiac transplantation, an estimated 12% of…
View article: Publisher Correction: Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes
Publisher Correction: Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes Open
View article: Type I interferon signaling and peroxisomal dysfunction contribute to enhanced inflammatory cytokine production in IRGM1-deficient macrophages
Type I interferon signaling and peroxisomal dysfunction contribute to enhanced inflammatory cytokine production in IRGM1-deficient macrophages Open
The human IRGM gene has been linked to inflammatory diseases including sepsis and Crohn's disease. Decreased expression of human IRGM, or the mouse orthologues Irgm1 and Irgm2, leads to increased production of a number of inflammatory chem…
View article: Meta-analysis of Genome wide Association Studies on Childhood ADHD Symptoms and Diagnosis Reveals 17 Novel Loci and 22 Potential Effector Genes
Meta-analysis of Genome wide Association Studies on Childhood ADHD Symptoms and Diagnosis Reveals 17 Novel Loci and 22 Potential Effector Genes Open
Attention-deficit/hyperactivity disorder (ADHD) is a heritable neurodevelopmental disorder for which genetic factors explain up to 75% of the variance. In this study, we performed a genome-wide association meta-analysis (GWAMA) of ADHD sym…
View article: Genetic changes from type I interferons and JAK inhibitors: clues to drivers of juvenile dermatomyositis
Genetic changes from type I interferons and JAK inhibitors: clues to drivers of juvenile dermatomyositis Open
Objective To better understand the pathogenesis of juvenile dermatomyositis (JDM), we examined the effect of the cytokines type I interferons (IFN I) and JAK inhibitor drugs (JAKi) on gene expression in bioengineered pediatric skeletal mus…
View article: Exome sequencing of hepatocellular carcinoma in lemurs identifies potential cancer drivers
Exome sequencing of hepatocellular carcinoma in lemurs identifies potential cancer drivers Open
Background and objectives Hepatocellular carcinoma occurs frequently in prosimians, but the cause of these liver cancers in this group is unknown. Characterizing the genetic changes associated with hepatocellular carcinoma in prosimians ma…
View article: Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course
Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course Open
View article: Genetic association study of childhood aggression across raters, instruments, and age.
Genetic association study of childhood aggression across raters, instruments, and age. Open
Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assesso…
View article: Genetic association study of childhood aggression across raters, instruments, and age
Genetic association study of childhood aggression across raters, instruments, and age Open
View article: Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction
Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction Open
View article: Association of childhood neighborhood disadvantage with young adult DNA methylation
Association of childhood neighborhood disadvantage with young adult DNA methylation Open
Importance: DNA methylation has been proposed as an epigenetic mechanism by which the childhood neighborhood environment may influence the genome to compromise adult health.Objective: To determine whether childhood neighborhood disadvantag…
View article: Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm
Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm Open
Biological aging is the gradual, progressive decline in system integrity that occurs with advancing chronological age, causing morbidity and disability. Measurements of the pace of aging are needed as surrogate endpoints in trials of thera…
View article: Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement
Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement Open
DNA methylation plays an important role in both normal human development and risk of disease. The most utilized method of assessing DNA methylation uses BeadChips, generating an epigenome-wide "snapshot" of >450,000 observations (probe mea…
View article: Author response: Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm
Author response: Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Biological aging is the gradu…
View article: From the Clinic to the Bench and Back Again in One Dog Year: How a Cross-Species Pipeline to Identify New Treatments for Sarcoma Illuminates the Path Forward in Precision Medicine
From the Clinic to the Bench and Back Again in One Dog Year: How a Cross-Species Pipeline to Identify New Treatments for Sarcoma Illuminates the Path Forward in Precision Medicine Open
Cancer drug discovery is an inefficient process, with more than 90% of newly-discovered therapies failing to gain regulatory approval. Patient-derived models of cancer offer a promising new approach to identify new treatments; however, for…
View article: Investigating the Genetic Architecture of Non-Cognitive Skills Using GWAS-by-Subtraction
Investigating the Genetic Architecture of Non-Cognitive Skills Using GWAS-by-Subtraction Open
Educational attainment (EA) is influenced by cognitive abilities and by other characteristics and traits. However little is known about the genetic architecture of these “non-cognitive” contributions to EA. Here, we use Genomic Structural …
View article: Genetic Association Study of Childhood Aggression across raters, instruments and age
Genetic Association Study of Childhood Aggression across raters, instruments and age Open
Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assesso…
View article: Using DNA From Mothers and Children to Study Parental Investment in Children’s Educational Attainment
Using DNA From Mothers and Children to Study Parental Investment in Children’s Educational Attainment Open
This study tested implications of new genetic discoveries for understanding the association between parental investment and children’s educational attainment. A novel design matched genetic data from 860 British mothers and their children …
View article: Establishing a generalized polyepigenetic biomarker for tobacco smoking
Establishing a generalized polyepigenetic biomarker for tobacco smoking Open
View article: From the clinic to the bench and back again in one dog year: identifying new treatments for sarcoma using a cross-species personalized medicine pipeline
From the clinic to the bench and back again in one dog year: identifying new treatments for sarcoma using a cross-species personalized medicine pipeline Open
Cancer drug discovery is an inefficient process, with more than 90% of newly-discovered therapies failing to gain regulatory approval. Patient-derived models of cancer offer a promising new approach to identifying personalized treatments; …
View article: Using DNA from mothers and children to study parental investment in children's educational attainment
Using DNA from mothers and children to study parental investment in children's educational attainment Open
This study tested implications of new genetic discoveries for understanding the association between parental investment and children's educational attainment. A novel design matched genetic data from 860 British mothers and their children …
View article: A Polygenic Score for Higher Educational Attainment is Associated with Larger Brains
A Polygenic Score for Higher Educational Attainment is Associated with Larger Brains Open
People who score higher on intelligence tests tend to have larger brains. Twin studies suggest the same genetic factors influence both brain size and intelligence. This has led to the hypothesis that genetics influence intelligence partly …
View article: Genetics & the Geography of Health, Behavior, and Attainment
Genetics & the Geography of Health, Behavior, and Attainment Open
People’s life chances can be predicted by their neighborhoods. This observation is driving efforts to improve lives by changing neighborhoods. Some neighborhood effects may be causal, supporting neighborhood-level interventions. Other neig…
View article: A Polygenic Score for Higher Educational Attainment is Associated with Larger Brains
A Polygenic Score for Higher Educational Attainment is Associated with Larger Brains Open
People who score higher on intelligence tests tend to have larger brains. Twin studies suggest the same genetic factors influence both brain size and intelligence. This has led to the hypothesis that genetics influence intelligence partly …
View article: Genetics and Crime: Integrating New Genomic Discoveries Into Psychological Research About Antisocial Behavior
Genetics and Crime: Integrating New Genomic Discoveries Into Psychological Research About Antisocial Behavior Open
Drawing on psychological and sociological theories of crime causation, we tested the hypothesis that genetic risk for low educational attainment (assessed via a genome-wide polygenic score) is associated with criminal offending. We further…
View article: Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing?
Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing? Open
The geroscience hypothesis posits that therapies to slow biological processes of aging can prevent disease and extend healthy years of life. To test such "geroprotective" therapies in humans, outcome measures are needed that can assess ext…
View article: Table of Contents
Table of Contents Open
View article: Telomere, epigenetic clock, and biomarker-composite quantifications of biological aging: Do they measure the same thing?
Telomere, epigenetic clock, and biomarker-composite quantifications of biological aging: Do they measure the same thing? Open
The geroscience hypothesis posits that therapies to retard biological processes of aging can prevent disease. To test such “geroprotective” therapies in humans, surrogate endpoints are needed for extension of disease-free lifespan. Methods…
View article: Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate
Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate Open
The DNA replication checkpoint (DRC) monitors and responds to stalled replication forks to prevent genomic instability. How core replication factors integrate into this phosphorylation cascade is incompletely understood. Here, through anal…
View article: Dynamic loading and redistribution of the Mcm2‐7 helicase complex through the cell cycle
Dynamic loading and redistribution of the Mcm2‐7 helicase complex through the cell cycle Open