Joseph C. Y. Chen
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View article: Central role for fast nociceptors in mechanical nocifensive behavior and sensitization
Central role for fast nociceptors in mechanical nocifensive behavior and sensitization Open
Nociceptors, primary afferent nerve fibers that signal noxious stimuli, are broadly divided into slowly conducting unmyelinated C fibers and fast-conducting myelinated A fibers. Whereas C-nociceptors have been extensively studied, consider…
View article: Optimal Honeypot Ratio and Convergent Fictitious-Play Learning in Signaling Games for CPS Defense
Optimal Honeypot Ratio and Convergent Fictitious-Play Learning in Signaling Games for CPS Defense Open
Cyber-Physical Systems (CPSs) are facing a fast-growing wave of attacks. To achieve effective proactive defense, this paper models honeypot deployment as a gamma-fixed signaling game in which node liveness serves as the only signal and nor…
View article: A NaV1.8FlpO mouse enabling selective intersectional targeting of low threshold C fiber mechanoreceptors and nociceptors
A NaV1.8FlpO mouse enabling selective intersectional targeting of low threshold C fiber mechanoreceptors and nociceptors Open
Genetic targeting of select populations of cells in the mouse nervous system is often hampered by a lack of selectivity, as candidate genes for such targeting are commonly expressed by multiple cell populations, also in the same region. In…
View article: 658 | RESPONSE TO EPCORITAMAB CORRELATEDS WITH HIGHER ALC/AMC RATIO: INSIGHTS FROM A REALWORLD RETROSPECTIVE ANALYSIS
658 | RESPONSE TO EPCORITAMAB CORRELATEDS WITH HIGHER ALC/AMC RATIO: INSIGHTS FROM A REALWORLD RETROSPECTIVE ANALYSIS Open
View article: Construction of a nomogram model for predicting delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage patients
Construction of a nomogram model for predicting delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage patients Open
Aneurysmal subarachnoid hemorrhage (aSAH) is a severe cerebrovascular disease.This retrospective two-center cohort study aimed to construct a nomogram model for predicting delayed cerebral ischemia (DCI) in aSAH patients using LASSO- logis…
View article: Genetic targeting of myelinated primary afferent neurons using a new NefhCreERT2 knock-in mouse
Genetic targeting of myelinated primary afferent neurons using a new NefhCreERT2 knock-in mouse Open
View article: Genetic targeting of myelinated primary afferent neurons using a new<i>Nefh<sup>CreERT2</sup></i>knock-in mouse
Genetic targeting of myelinated primary afferent neurons using a new<i>Nefh<sup>CreERT2</sup></i>knock-in mouse Open
Primary afferent neurons that convey somatosensory modalities comprise two large, heterogeneous populations: small-diameter neurons that give rise to slowly conducting unmyelinated axonal C fibers and medium-to-large diameter neurons with …
View article: A fast nociceptive subsystem mediating rapid reflexive behavior but not affective pain
A fast nociceptive subsystem mediating rapid reflexive behavior but not affective pain Open
Spinal nociceptive withdrawal reflexes are widely believed to rely on unmyelinated and thinly myelinated nociceptive fibers that also signal affective and motivational aspects of pain. Here we discover a population of myelinated mechanorec…
View article: A NaV1.8<sup>FlpO</sup>mouse enabling selective intersectional targeting of low threshold C fiber mechanoreceptors and nociceptors
A NaV1.8<sup>FlpO</sup>mouse enabling selective intersectional targeting of low threshold C fiber mechanoreceptors and nociceptors Open
Genetic targeting of select populations of cells in the mouse nervous system is often hampered by a lack of selectivity, as candidate genes for such targeting are commonly expressed by multiple cell populations, also in the same region. In…
View article: Advancing Structural Self-Healing in Green Intelligent Buildings through Bio-Based Materials
Advancing Structural Self-Healing in Green Intelligent Buildings through Bio-Based Materials Open
View article: The Temporal Brain and Temporal Processor: A Future-Oriented Cognitive and Computational Model Based on the Time Dimension
The Temporal Brain and Temporal Processor: A Future-Oriented Cognitive and Computational Model Based on the Time Dimension Open
View article: Quantum Probability Waves in Higher-Dimensional Spacetime: Deterministic Implications and Uncertainty
Quantum Probability Waves in Higher-Dimensional Spacetime: Deterministic Implications and Uncertainty Open
View article: ASDLM: A Unified Framework for Adaptive, Cross-Modal, and Self-Optimizing Artificial Intelligence
ASDLM: A Unified Framework for Adaptive, Cross-Modal, and Self-Optimizing Artificial Intelligence Open
View article: Trans-Spatiotemporal Bio-Information Fusion System: A Multidimensional Communication Framework Utilizing Quantum Entanglement, Gravitational Waves, Superluminal Particles, and Biological Networks
Trans-Spatiotemporal Bio-Information Fusion System: A Multidimensional Communication Framework Utilizing Quantum Entanglement, Gravitational Waves, Superluminal Particles, and Biological Networks Open
View article: Sclerosing pneumocytoma with rosette structure mimicking carcinoid: A diagnostic pitfall of intraoperative consultation
Sclerosing pneumocytoma with rosette structure mimicking carcinoid: A diagnostic pitfall of intraoperative consultation Open
View article: Beyond regulatory compliance: evaluating radiology artificial intelligence applications in deployment
Beyond regulatory compliance: evaluating radiology artificial intelligence applications in deployment Open
The implementation of artificial intelligence (AI) applications in routine practice, following regulatory approval, is currently limited by practical concerns around reliability, accountability, trust, safety, and governance, in addition t…
View article: Retraction Note: Fuzzy C-means robust algorithm for nonlinear systems
Retraction Note: Fuzzy C-means robust algorithm for nonlinear systems Open
View article: Retraction Note: An Intelligent Algorithm Optimum for Building Design of Fuzzy Structures
Retraction Note: An Intelligent Algorithm Optimum for Building Design of Fuzzy Structures Open
View article: The use of 99mTc-PYP SPECT/CT in monitoring therapeutic changes of eplontersen in patients with hereditary transthyretin cardiomyopathy
The use of 99mTc-PYP SPECT/CT in monitoring therapeutic changes of eplontersen in patients with hereditary transthyretin cardiomyopathy Open
Objective Hereditary transthyretin amyloid cardiomyopathy (hATTR-CM) is a progressive and fatal disease. Emerging data suggests the potential role of technetium-99m (99mTc)-pyrophosphate (PYP) scintigraphy to monitor the efficacy of ATTR-C…
View article: PB1081 Identification of Related Molecular Biological Effects on Two Novel Point Mutations in Inherited Antithrombin Deficiency
PB1081 Identification of Related Molecular Biological Effects on Two Novel Point Mutations in Inherited Antithrombin Deficiency Open
View article: A-140 Evaluating the Performance of Various Lupus Anticoagulants Tests Among Different Coagulation Platforms
A-140 Evaluating the Performance of Various Lupus Anticoagulants Tests Among Different Coagulation Platforms Open
Background Lupus Anticoagulants (LAs), one of the antiphospholipid antibodies, are risk factors for arterial or venous thrombosis with complications such as stroke, acquired thrombophilia, and pregnancy loss. Detection of LAs is challengin…
View article: Retraction Note: A New Viewpoint on Control Algorithms for Anthropomorphic Robotic Arms
Retraction Note: A New Viewpoint on Control Algorithms for Anthropomorphic Robotic Arms Open
View article: P-119 HGCSG 1803: Single-arm phase Ⅱ study evaluating efficacy of oxaliplatin, irinotecan and S-1 combination therapy (OX-IRIS) in metastatic pancreatic cancer as first-line treatment
P-119 HGCSG 1803: Single-arm phase Ⅱ study evaluating efficacy of oxaliplatin, irinotecan and S-1 combination therapy (OX-IRIS) in metastatic pancreatic cancer as first-line treatment Open
View article: Supplementary Material for: Patient-reported Outcomes in Young Adults with Myeloproliferative Neoplasms
Supplementary Material for: Patient-reported Outcomes in Young Adults with Myeloproliferative Neoplasms Open
Introduction Genetic landscape, disease characteristics and clinical outcomes of young adults with myeloproliferative neoplasms (MPNs) were reported. However, data on patient-reported outcomes (PROs) in young adults with MPNs were rare. Me…
View article: Detection Analysis of Perioperative Plasma and CSF Reveals Risk Biomarkers of Postoperative Delirium of Parkinson&rsquo;s Disease Patients Undergoing Deep Brain Stimulation of the Subthalamic Nuclei
Detection Analysis of Perioperative Plasma and CSF Reveals Risk Biomarkers of Postoperative Delirium of Parkinson’s Disease Patients Undergoing Deep Brain Stimulation of the Subthalamic Nuclei Open
Yongde Zhou,1 Yu Ma,2 Cuiping Yu,1 Yao Chen,1 Jian Ding,1 Jianfeng Yu,1 Rongsong Zhou,2 Xiaoxiao Wang,3 Ting Fan,1 Chengmei Shi4 1Department of Anesthesiology, Tsinghua University Yuquan Hospital, Beijing, People’s Republic of China; 2Depa…
View article: Issue Information
Issue Information Open
View article: Now open: Evolving insights to the roles of lysine acetylation in chromatin organization and function
Now open: Evolving insights to the roles of lysine acetylation in chromatin organization and function Open
View article: Usp22 Overexpression Leads to Aberrant Signal Transduction of Cancer-Related Pathways but Is Not Sufficient to Drive Tumor Formation in Mice
Usp22 Overexpression Leads to Aberrant Signal Transduction of Cancer-Related Pathways but Is Not Sufficient to Drive Tumor Formation in Mice Open
Usp22 overexpression is observed in several human cancers and is correlated with poor patient outcomes. The molecular basis underlying this correlation is not clear. Usp22 is the catalytic subunit of the deubiquitylation module in the SAGA…
View article: Conservation and diversity of the eukaryotic SAGA coactivator complex across kingdoms
Conservation and diversity of the eukaryotic SAGA coactivator complex across kingdoms Open
The SAGA complex is an evolutionarily conserved transcriptional coactivator that regulates gene expression through its histone acetyltransferase and deubiquitylase activities, recognition of specific histone modifications, and interactions…
View article: P21.12 An Observational Study of Treatment Outcome in Stage III Lung Cancer Patients in Taiwan: KINDLE study
P21.12 An Observational Study of Treatment Outcome in Stage III Lung Cancer Patients in Taiwan: KINDLE study Open