Joseph C. Mays
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View article: C/EBPβ-mediated PARP1 Suppression Drives Tumor Progression of Aneuploid Cells
C/EBPβ-mediated PARP1 Suppression Drives Tumor Progression of Aneuploid Cells Open
Summary Aneuploidy—defined as gains and losses of chromosomes—is frequently observed in cancer and has been implicated in promoting tumor progression and metastasis. However, the molecular mechanisms underlying this phenomenon remain poorl…
View article: KaryoTap Enables Aneuploidy Detection in Thousands of Single Human Cells
KaryoTap Enables Aneuploidy Detection in Thousands of Single Human Cells Open
Output of Tapestri Pipeline for experiments used in Mays et al., 2023 publication.
View article: KaryoTap Enables Aneuploidy Detection in Thousands of Single Human Cells
KaryoTap Enables Aneuploidy Detection in Thousands of Single Human Cells Open
Investigating chromosomal instability and aneuploidy within tumors is essential for understanding tumorigenesis and developing diagnostic and therapeutic strategies. Single-cell DNA sequencing technologies have enabled such analyses, revea…
View article: KaryoTap Enables Aneuploidy Detection in Thousands of Single Human Cells
KaryoTap Enables Aneuploidy Detection in Thousands of Single Human Cells Open
Output of Tapestri Pipeline for experiments used in Mays et al., 2023 publication.
View article: KaryoCreate: A CRISPR-based technology to study chromosome-specific aneuploidy by targeting human centromeres
KaryoCreate: A CRISPR-based technology to study chromosome-specific aneuploidy by targeting human centromeres Open
View article: KaryoCreate: a new CRISPR-based technology to generate chromosome-specific aneuploidy by targeting human centromeres
KaryoCreate: a new CRISPR-based technology to generate chromosome-specific aneuploidy by targeting human centromeres Open
SUMMARY Aneuploidy, the presence of chromosome gains or losses, is a hallmark of cancer and congenital syndromes. Here, we describe KaryoCreate ( Karyo type CR ISPR E ngineered A neuploidy Te chnology), a system that enables generation of …
View article: Proteogenomic analysis of cancer aneuploidy and normal tissues reveals divergent modes of gene regulation across cellular pathways
Proteogenomic analysis of cancer aneuploidy and normal tissues reveals divergent modes of gene regulation across cellular pathways Open
How cells control gene expression is a fundamental question. The relative contribution of protein-level and RNA-level regulation to this process remains unclear. Here, we perform a proteogenomic analysis of tumors and untransformed cells c…
View article: Author response: Proteogenomic analysis of cancer aneuploidy and normal tissues reveals divergent modes of gene regulation across cellular pathways
Author response: Proteogenomic analysis of cancer aneuploidy and normal tissues reveals divergent modes of gene regulation across cellular pathways Open
View article: Characterization of the development of the mouse cochlear epithelium at the single cell level
Characterization of the development of the mouse cochlear epithelium at the single cell level Open
Mammalian hearing requires the development of the organ of Corti, a sensory epithelium comprising unique cell types. The limited number of each of these cell types, combined with their close proximity, has prevented characterization of ind…
View article: Not all cancers are created equal: Tissue specificity in cancer genes and pathways
Not all cancers are created equal: Tissue specificity in cancer genes and pathways Open
View article: Single Cell Sequencing of the Pineal Gland: The Next Chapter
Single Cell Sequencing of the Pineal Gland: The Next Chapter Open
The analysis of pineal cell biology has undergone remarkable development as techniques have become available which allow for sequencing of entire transcriptomes and, most recently, the sequencing of the transcriptome of individual cells. I…
View article: Single-cell RNA sequencing of the mammalian pineal gland identifies two pinealocyte subtypes and cell type-specific daily patterns of gene expression
Single-cell RNA sequencing of the mammalian pineal gland identifies two pinealocyte subtypes and cell type-specific daily patterns of gene expression Open
The vertebrate pineal gland is dedicated to the production of the hormone melatonin, which increases at night to influence circadian and seasonal rhythms. This increase is associated with dramatic changes in the pineal transcriptome. Here,…