Joseph H. Friedman
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View article: Developing Medical Cannabis Competencies
Developing Medical Cannabis Competencies Open
Importance The use of medical cannabis continues to expand rapidly across the US, yet most health care practitioners and trainees report feeling unprepared to counsel patients or integrate cannabis into care. Despite its clinical relevance…
View article: What Does ’Polysubstance’ Really Mean? Comparing Drug-Involved Deaths in Los Angeles in CDC Records vs. Detailed Medical Examiner Data
What Does ’Polysubstance’ Really Mean? Comparing Drug-Involved Deaths in Los Angeles in CDC Records vs. Detailed Medical Examiner Data Open
Introduction The ongoing overdose crisis in the United States is increasingly characterized by polysubstance involvement, shifting beyond single-drug fatalities to complex combinations that present novel public health challenges. However, …
View article: Episodic Coma in Lewy Body Disorders: An Observational Report
Episodic Coma in Lewy Body Disorders: An Observational Report Open
Background and Purpose: Episodes of unresponsiveness are one of several criteria used to diagnose dementia with Lewy bodies and are also seen in people with Parkinson’s disease dementia. Patients examined during episodes of coma, whose eva…
View article: Pathologically Confirmed Alzheimer's Disease Presenting as Clinical Parkinson's Disease, A Case Report
Pathologically Confirmed Alzheimer's Disease Presenting as Clinical Parkinson's Disease, A Case Report Open
Background It is well known that rare cases of Alzheimer's disease (AD) pathology may cause corticobasal or posterior cortical atrophy syndromes, and that cases with advanced AD may develop parkinsonism. However, reports of parkinsonism as…
View article: P587 Development and Characterization of a Novel Extended Half-life Monoclonal Antibody Drug Candidate Targeting Integrin ɑ4β7 for the Treatment of IBD
P587 Development and Characterization of a Novel Extended Half-life Monoclonal Antibody Drug Candidate Targeting Integrin ɑ4β7 for the Treatment of IBD Open
Background Antagonism of the interaction between the cellular adhesion integrin ɑ4β7 and endothelial ligand mucosal addressin cell-adhesion molecule-1 (MAdCAM-1) is a safe and effective mechanism to treat Crohn’s disease (CD) and ulcerativ…
View article: Endovascular management of colic artery pseudoaneurysm: A case report of successful intervention in a 59-year-old male with abdominal hematoma
Endovascular management of colic artery pseudoaneurysm: A case report of successful intervention in a 59-year-old male with abdominal hematoma Open
Visceral artery pseudoaneurysms, including inferior mesenteric artery pseudoaneurysms, are rare, occurring at an estimated incidence of 0.01%-0.2%. The literature reports only around 60 cases of inferior mesenteric pseudoaneurysm to date. …
View article: Reliability of the Clinician’s Tardive Inventory (CTI)
Reliability of the Clinician’s Tardive Inventory (CTI) Open
Objectives Currently utilized clinician-rated symptom scales for tardive dyskinesia (TD) have not kept up with the expanding spectrum of TD phenomenology. The objective of this study was to develop and test the reliability of a new instrum…
View article: Inpatient Mortality in Parkinson’s Disease
Inpatient Mortality in Parkinson’s Disease Open
Introduction Although a majority of the American public prefer to die at home, a large percentage of Parkinson’s disease patients die in acute care hospitals. We examine trends in the clinical and demographic characteristics of Parkinson’s…
View article: Calcification in Thoracic Splenosis
Calcification in Thoracic Splenosis Open
Splenosis is a rare condition described as the implantation of ectopic splenic tissue, usually after a splenic rupture. Thoracic splenosis refers to acquired ectopic splenic tissue found within the thoracic cavity, often caused by thoracoa…
View article: Clozapine Is Severely Underused in Parkinson's Disease Patients
Clozapine Is Severely Underused in Parkinson's Disease Patients Open
Clozapine is a unique drug for people with Parkinson's disease (PD). It was the first drug shown to be an effective antipsychotic that did not worsen motor function.1, 2 It was the first drug shown in a double-blind, placebo-controlled tri…
View article: Immediate-release/extended-release amantadine (OS320) to treat Parkinson's disease with levodopa-induced dyskinesia: Analysis of the randomized, controlled ALLAY-LID studies
Immediate-release/extended-release amantadine (OS320) to treat Parkinson's disease with levodopa-induced dyskinesia: Analysis of the randomized, controlled ALLAY-LID studies Open
BackgroundImmediate-release (IR) amantadine has been used for treatment of levodopa induced dyskinesia (LID). The immediate-release/extended-release (IR/ER) amantadine formulation OS320 (OSMOLEX ER®) contains an IR outer layer and ER core …
View article: Evaluating Oculomotor Tests before and after Vestibular Rehabilitation in Patients with Parkinson’s Disease: A Pilot Pre‐Post Study
Evaluating Oculomotor Tests before and after Vestibular Rehabilitation in Patients with Parkinson’s Disease: A Pilot Pre‐Post Study Open
Introduction . The elderly population is commonly affected by balance and gait disorders that increase the risk of falls. Pivotal systems for efficient postural control are sensory, motor, visual, vestibular, and cognitive. Disruption in a…
View article: Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression
Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression Open
ClinicalTrials.gov Identifier: NCT02642393.
View article: Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3
Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3 Open
As clinical trials for SCA3 advance, urine polyQ ATXN3 protein has potential to be a useful, non-invasive and inexpensive biomarker for SCA3.
View article: Non-Motor Symptoms and Associated Factors in Parkinson’s Disease Patients in Addis Ababa, Ethiopia: A Multicenter Cross-Sectional Study
Non-Motor Symptoms and Associated Factors in Parkinson’s Disease Patients in Addis Ababa, Ethiopia: A Multicenter Cross-Sectional Study Open
BACKGROUND: Non-motor symptoms (NMSs) of Parkinson’s disease (PD) were often overlooked and less studied. Little is known about NMSs in Ethiopia. The aim of the study was to determine the prevalence of NMSs and associated factors.METHODS: …
View article: Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3
Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3 Open
PolyQ ATXN3 is a pharmacodynamic marker for SCA3, and a SNP associated with the expanded allele may serve to specifically target mutant ATXN3 .
View article: Effects of Vestibular Rehabilitation on Fatigue and Activities of Daily Living in People with Parkinson’s Disease: A Pilot Randomized Controlled Trial Study
Effects of Vestibular Rehabilitation on Fatigue and Activities of Daily Living in People with Parkinson’s Disease: A Pilot Randomized Controlled Trial Study Open
One of the most disabling nonmotor symptoms in persons with Parkinson’s disease is fatigue, which can decrease the quality of life by restricting the function and activities of daily living (ADL). Nonetheless, sufficient evidence for treat…
View article: Sleep disturbances in Parkinson’s disease: beyond a regional perspective. Time to do something about it
Sleep disturbances in Parkinson’s disease: beyond a regional perspective. Time to do something about it Open
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