Joseph G. Knotts
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View article: Characterization of an expanded set of assays for immunomodulatory proteins using targeted mass spectrometry
Characterization of an expanded set of assays for immunomodulatory proteins using targeted mass spectrometry Open
View article: A multiplexed assay for quantifying immunomodulatory proteins supports correlative studies in immunotherapy clinical trials
A multiplexed assay for quantifying immunomodulatory proteins supports correlative studies in immunotherapy clinical trials Open
Introduction Immunotherapy is an effective treatment for a subset of cancer patients, and expanding the benefits of immunotherapy to all cancer patients will require predictive biomarkers of response and immune-related adverse events (irAE…
View article: Targeted Mass Spectrometry Enables Multiplexed Quantification of Immunomodulatory Proteins in Clinical Biospecimens
Targeted Mass Spectrometry Enables Multiplexed Quantification of Immunomodulatory Proteins in Clinical Biospecimens Open
Immunotherapies are revolutionizing cancer care, producing durable responses and potentially cures in a subset of patients. However, response rates are low for most tumors, grade 3/4 toxicities are not uncommon, and our current understandi…
View article: Targeted Mass Spectrometry Enables Quantification of Novel Pharmacodynamic Biomarkers of ATM Kinase Inhibition
Targeted Mass Spectrometry Enables Quantification of Novel Pharmacodynamic Biomarkers of ATM Kinase Inhibition Open
The ATM serine/threonine kinase (HGNC: ATM) is involved in initiation of repair of DNA double-stranded breaks, and ATM inhibitors are currently being tested as anti-cancer agents in clinical trials, where pharmacodynamic (PD) assays are cr…
View article: A dataset describing a suite of novel antibody reagents for the RAS signaling network
A dataset describing a suite of novel antibody reagents for the RAS signaling network Open
RAS genes are frequently mutated in cancer and have for decades eluded effective therapeutic attack. The National Cancer Institute’s RAS Initiative has a focus on understanding pathways and discovering therapies for RAS-driven cancers. Par…
View article: Western blot data
Western blot data Open
Images of Western blots from screening the monoclonal antibodies (mAbs) using recombinant proteins and cell line lysates.
View article: Results Summary Tables and Data Tables
Results Summary Tables and Data Tables Open
The Results Summary Tables and Data Tables list monoclonal antibodies that enable detection of RAS signaling network proteins using Western blotting, immunoprecipitation, protein array, immunohistochemistry, and peptide immunoaffinity enri…