Joseph J. Vitti
YOU?
Author Swipe
View article: Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever
Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever Open
View article: Three linked variants have opposing regulatory effects on isovaleryl-CoA dehydrogenase gene expression
Three linked variants have opposing regulatory effects on isovaleryl-CoA dehydrogenase gene expression Open
While genome-wide association studies (GWAS) and positive selection scans identify genomic loci driving human phenotypic diversity, functional validation is required to discover the variant(s) responsible. We dissected the IVD gene locus—w…
View article: Three linked opposing regulatory variants under selection associate with<i>IVD</i>
Three linked opposing regulatory variants under selection associate with<i>IVD</i> Open
While genome-wide association studies (GWAS) and selection scans identify genomic loci driving human phenotypic diversity, functional validation is required to discover the variant(s) responsible. We dissected the IVD locus, implicated by …
View article: Identifying and Characterizing Adaptive Regulatory Variation in Diverse Human Populations
Identifying and Characterizing Adaptive Regulatory Variation in Diverse Human Populations Open
Recently expanded efforts to catalogue genomic diversity within and among human populations offer new opportunities for understanding human history and biology. The lens of adaptive evolution is a powerful framework with which to interpret…
View article: Identifying the favored mutation in a positive selective sweep
Identifying the favored mutation in a positive selective sweep Open
View article: Fine-mapping the Favored Mutation in a Positive Selective Sweep
Fine-mapping the Favored Mutation in a Positive Selective Sweep Open
Methods to identify signatures of selective sweeps in population genomics data have been actively developed, but mostly do not identify the specific mutation favored by the selective sweep. We present a method, iSAFE, that uses a statistic…
View article: Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus
Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus Open