Joseph K. McLaughlin
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View article: Senescence Signatures Predict Hospitalization Risk and Severity in COVID-19 Patients
Senescence Signatures Predict Hospitalization Risk and Severity in COVID-19 Patients Open
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic associated with substantial morbidity and mortality worldwide, with a particular risk for severe…
View article: Potential Plasma Proteins (LGALS9, LAMP3, PRSS8 and AGRN) as Predictors of Hospitalisation Risk in COVID-19 Patients
Potential Plasma Proteins (LGALS9, LAMP3, PRSS8 and AGRN) as Predictors of Hospitalisation Risk in COVID-19 Patients Open
Background: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has posed unprecedented challenges to healthcare systems worldwide. Here, we have identified proteomic and genetic signatures for improved prognosis which is vi…
View article: LGALS9, LAMP3, PRSS8 and AGRN Predict Hospitalisation Risk in COVID-19 Patients
LGALS9, LAMP3, PRSS8 and AGRN Predict Hospitalisation Risk in COVID-19 Patients Open
Background: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2 has posed unprecedented challenges to healthcare systems worldwide. Here, we have identified proteomic and genetic signatures for improved prognosis which is vit…
View article: Temporally Associated Invasive Pneumococcal Disease and SARS-CoV-2 Infection, Alaska, USA, 2020–2021
Temporally Associated Invasive Pneumococcal Disease and SARS-CoV-2 Infection, Alaska, USA, 2020–2021 Open
Streptococcus pneumoniae can co-infect persons who have viral respiratory tract infections. However, research on S. pneumoniae infections that are temporally associated with SARS-CoV-2 infections is limited. We described the epidemiology a…
View article: An assessment of the impact of Raman based glucose feedback control on <scp>CHO</scp> cell bioreactor process development
An assessment of the impact of Raman based glucose feedback control on <span>CHO</span> cell bioreactor process development Open
Process analytical technology (PAT) tools such as Raman Spectroscopy have become established tools for real time measurement of CHO cell bioreactor process variables and are aligned with the QbD approach to manufacturing. These tools can h…
View article: Table S1. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer
Table S1. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer Open
Lung cancer cohorts description.
View article: Figure S4. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer
Figure S4. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer Open
Modulation of PD-L1, IDO-1 and B7-H4 levels by cytokines in lung adenocarcinoma cells.
View article: Figure S2. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer
Figure S2. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer Open
Association between PD-L1, IDO-1 and B7-H4 signal and survival in lung cancer.
View article: Figure S1. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer
Figure S1. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer Open
Validation of IDO-1 and B7-H4 assays.
View article: Figure S3. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer
Figure S3. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer Open
Simultaneous detection of PD-L1, IDO-1 and B7-H4 in lung cancer.
View article: Figure S3. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer
Figure S3. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer Open
Simultaneous detection of PD-L1, IDO-1 and B7-H4 in lung cancer.
View article: Figure S1. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer
Figure S1. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer Open
Validation of IDO-1 and B7-H4 assays.
View article: Figure S2. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer
Figure S2. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer Open
Association between PD-L1, IDO-1 and B7-H4 signal and survival in lung cancer.
View article: Figure S4. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer
Figure S4. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer Open
Modulation of PD-L1, IDO-1 and B7-H4 levels by cytokines in lung adenocarcinoma cells.
View article: Data from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer
Data from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer Open
Purpose: To determine the expression level, associations, and biological role of PD-L1, IDO-1, and B7-H4 in non–small cell lung cancer (NSCLC).Experimental Design: Using multiplexed quantitative immunofluorescence (QIF), we measured the le…
View article: Table S1. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer
Table S1. from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer Open
Lung cancer cohorts description.
View article: Data from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer
Data from Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer Open
Purpose: To determine the expression level, associations, and biological role of PD-L1, IDO-1, and B7-H4 in non–small cell lung cancer (NSCLC).Experimental Design: Using multiplexed quantitative immunofluorescence (QIF), we measured the le…
View article: Increased Mortality Among Persons With Symptomatic Coronavirus Disease 2019 (COVID-19) During the Period of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) B.1.617.2 (Delta Variant) Predominance: Alaska, November 2020–October 2021
Increased Mortality Among Persons With Symptomatic Coronavirus Disease 2019 (COVID-19) During the Period of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) B.1.617.2 (Delta Variant) Predominance: Alaska, November 2020–October 2021 Open
We compared the mortality risk in Alaska among persons with symptomatic coronavirus disease 2019 (COVID-19) during the period the Delta variant was predominant to the risk among those with symptomatic COVID-19 before Delta predominance. Th…
View article: Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice
Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice Open
Upon oral dosing in mice, HC-070 achieves exposure levels in the brain and plasma deemed sufficient to test behavioral activity. Treatment with HC-070 attenuates the anxiogenic effect of CCK-4 in the elevated plus maze (EPM). The compound …
View article: Correction: Corrigendum: Determining crystal structures through crowdsourcing and coursework
Correction: Corrigendum: Determining crystal structures through crowdsourcing and coursework Open
Nature Communications 7: Article number:12549 (2016); Published 16 September 2016; Updated 25 October 2016 The original version of this Article contained an error in the spelling of a member of the University of Michigan students Consortiu…