Joseph Kwan
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View article: Development and Validation of the IC3: An Online Remote Assessment Technology for Deep Phenotyping and Monitoring of Cognitive Impairment After Stroke
Development and Validation of the IC3: An Online Remote Assessment Technology for Deep Phenotyping and Monitoring of Cognitive Impairment After Stroke Open
Automated cognitive assessments tailored to specific clinical scenarios have the potential to revolutionize health care and clinical research. Stroke survivors experience significant burden from underdiagnosed cognitive deficits. To addres…
View article: Mitigating the impact of motor impairment on self-administered digital tests: a longitudinal cohort study in stroke
Mitigating the impact of motor impairment on self-administered digital tests: a longitudinal cohort study in stroke Open
View article: Frailty, Fitness, and Quality of Life Outcomes of a Healthy and Productive Aging Program (GrandMove) for Older Adults With Frailty or Prefrailty: Cluster Randomized Controlled Trial
Frailty, Fitness, and Quality of Life Outcomes of a Healthy and Productive Aging Program (GrandMove) for Older Adults With Frailty or Prefrailty: Cluster Randomized Controlled Trial Open
Background Exercise interventions can reverse frailty. However, their scalability and sustainability are limited by manpower, which is reducing due to population aging. GrandMove is a program that combines healthy and productive aging stra…
View article: The prevalence of binge eating and binge eating disorder in adults seeking obesity treatment
The prevalence of binge eating and binge eating disorder in adults seeking obesity treatment Open
Adults living with obesity have a higher risk of eating disorders and disordered eating behaviours such as binge eating (1,2) . However, the prevalence of disordered eating/eating disorders in adults presenting for obesity treatment is unk…
View article: Mitigating the impact of motor impairment on self-administered digital tests in patients with neurological disorders
Mitigating the impact of motor impairment on self-administered digital tests in patients with neurological disorders Open
Introduction Cognitive impairments are prevalent in many neurological disorders and remain underdiagnosed and poorly studied longitudinally. Unsupervised remote cognitive testing is an accessible, scalable, and cost-effective solution, how…
View article: Management of Acute Ischemic Stroke Following Transcatheter Aortic Valve Implantation: A Systematic Review and Multidisciplinary Treatment Recommendations
Management of Acute Ischemic Stroke Following Transcatheter Aortic Valve Implantation: A Systematic Review and Multidisciplinary Treatment Recommendations Open
Background/Objectives: Acute ischemic stroke is an uncommon but potentially devastating complication of Transcatheter Aortic Valve Implantation (TAVI). Despite improvements in device technology and procedural techniques, stroke rates have …
View article: How does lighting and visual task affect gait performance in patients with severe peripheral visual field loss?
How does lighting and visual task affect gait performance in patients with severe peripheral visual field loss? Open
How does lighting and visual task affect gait performance in patients with severe peripheral visual field loss?
View article: Cardiovascular Autonomic Dysfunction in Hospitalized Patients with a Bacterial Infection: A Longitudinal Observational Pilot Study in the UK
Cardiovascular Autonomic Dysfunction in Hospitalized Patients with a Bacterial Infection: A Longitudinal Observational Pilot Study in the UK Open
Purpose: A temporal reduction in the cardiovascular autonomic responses predisposes patients to cardiovascular instability after a viral infection and therefore increases the risk of associated complications. These findings have not been r…
View article: Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality
Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality Open
This corrects the article "Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality" in Volume 24 on page 256.
View article: Introducing the IC3 study - Deep cognitive phenotyping of patients with cerebrovascular disease in relation to novel plasma and MRI brain biomarkers
Introducing the IC3 study - Deep cognitive phenotyping of patients with cerebrovascular disease in relation to novel plasma and MRI brain biomarkers Open
Introduction: Cerebrovascular disease is a leading cause of death and disability worldwide. Identification and treatment of cognitive impairment following cerebrovascular disease (such as following stroke) remains a large unmet need. There…
View article: Outcomes of mechanical thrombectomy in acute stroke patients with atrial fibrillation detected after stroke versus known atrial fibrillation
Outcomes of mechanical thrombectomy in acute stroke patients with atrial fibrillation detected after stroke versus known atrial fibrillation Open
View article: Safety and outcomes of different endovascular treatment techniques for anterior circulation ischaemic stroke in the elderly: data from the Imperial College Thrombectomy Registry
Safety and outcomes of different endovascular treatment techniques for anterior circulation ischaemic stroke in the elderly: data from the Imperial College Thrombectomy Registry Open
View article: IC3 protocol: a longitudinal observational study of cognition after stroke using novel digital health technology
IC3 protocol: a longitudinal observational study of cognition after stroke using novel digital health technology Open
Introduction Stroke is a major cause of death and disability worldwide, frequently resulting in persistent cognitive deficits among survivors. These deficits negatively impact recovery and therapy engagement, and their treatment is consist…
View article: Inflammatory Cytokines Are Associated with Cognitive Dysfunction and Depressive State during Acute Bacterial Infections and the Recovery Phase
Inflammatory Cytokines Are Associated with Cognitive Dysfunction and Depressive State during Acute Bacterial Infections and the Recovery Phase Open
During a bacterial infection, individuals may present with behavioral changes referred to as sickness behavior, which has been suggested is induced by the inflammatory markers that are released because of the infective immunological challe…
View article: IC3 Protocol – A novel digital health method for monitoring cognition after stroke
IC3 Protocol – A novel digital health method for monitoring cognition after stroke Open
Introduction Stroke is a major cause of death and disability worldwide, frequently resulting in persistent cognitive deficits among survivors. These deficits negatively impact recovery and therapy engagement, and their treatment is consist…
View article: Outcomes of mechanical thrombectomy in orally anticoagulated patients with anterior circulation large vessel occlusion: a propensity-matched analysis of the Imperial College Thrombectomy Registry
Outcomes of mechanical thrombectomy in orally anticoagulated patients with anterior circulation large vessel occlusion: a propensity-matched analysis of the Imperial College Thrombectomy Registry Open
View article: Advances in mechanical thrombectomy for acute ischaemic stroke
Advances in mechanical thrombectomy for acute ischaemic stroke Open
Mechanical thrombectomy is a ground breaking treatment for acute ischaemic stroke caused by occlusion of a large vessel. Its efficacy over intravenous thrombolysis has been proven in multiple trials with a lower number needed to treat than…
View article: Barriers and Facilitators of People with and without Disabilities before and after Autonomous Shuttle Exposure
Barriers and Facilitators of People with and without Disabilities before and after Autonomous Shuttle Exposure Open
The deployment of autonomous shuttles (ASs) holds health and safety benefits for people with and without disabilities. Transportation is critical in helping people with disabilities (PWDs) access health care, services, and jobs, but the cu…
View article: Multiple Roads to Success: A Latent Class Analysis on Successful Aging in Hong Kong Near-Centenarians and Centenarians (NCC) Amidst COVID-19
Multiple Roads to Success: A Latent Class Analysis on Successful Aging in Hong Kong Near-Centenarians and Centenarians (NCC) Amidst COVID-19 Open
Background: Notwithstanding successful aging being a multidimensional construct, measuring successful aging in adults of advanced age, such as nonagenarians and centenarians, has often been challenging. First, over reliance on physical hea…
View article: Endovascular Thrombectomy with or without Intravenous Thrombolysis for Anterior Circulation Large Vessel Occlusion in the Imperial College London Thrombectomy Registry
Endovascular Thrombectomy with or without Intravenous Thrombolysis for Anterior Circulation Large Vessel Occlusion in the Imperial College London Thrombectomy Registry Open
Background and purpose. Mechanical thrombectomy (MT) is the standard of care for eligible patients with a large vessel occlusion (LVO) acute ischemic stroke. Among patients undergoing MT there has been uncertainty regarding the role of int…
View article: Comparison of Drip‐and‐Ship Versus Mothership Delivery Models of Mechanical Thrombectomy Delivery
Comparison of Drip‐and‐Ship Versus Mothership Delivery Models of Mechanical Thrombectomy Delivery Open
Background It remains uncertain whether the drip‐and‐ship (DS) strategy (transport to the nearest primary stroke centers) or the mothership (MS) model (direct transportation to the comprehensive stroke center) is the organizational stroke …
View article: Correction: Mechanical thrombectomy in acute basilar artery stroke: a systematic review and Meta-analysis of randomized controlled trials
Correction: Mechanical thrombectomy in acute basilar artery stroke: a systematic review and Meta-analysis of randomized controlled trials Open
View article: Mechanical thrombectomy in acute basilar artery stroke: a systematic review and Meta-analysis of randomized controlled trials
Mechanical thrombectomy in acute basilar artery stroke: a systematic review and Meta-analysis of randomized controlled trials Open
View article: Predictors of Simulator Sickness Provocation in a Driving Simulator Operating in Autonomous Mode
Predictors of Simulator Sickness Provocation in a Driving Simulator Operating in Autonomous Mode Open
Highly autonomous vehicles (HAV) have the potential of improving road safety and providing alternative transportation options. Given the novelty of HAVs, high-fidelity driving simulators operating in an autonomous mode are a great way to e…
View article: COMPARING SUCCESSFUL AGING OF NEAR-CENTENARIANS AND CENTENARIANS: FINDINGS FROM 2011 AND 2021/22
COMPARING SUCCESSFUL AGING OF NEAR-CENTENARIANS AND CENTENARIANS: FINDINGS FROM 2011 AND 2021/22 Open
Successful aging (SA) was proposed by Robert J Havighurst in 1961 to capture how older adults add “lives onto (their) years.” While there is a consensus regarding the multidimensionality of the concept, the set of criteria that should be a…
View article: SURVIVAL OF THE FITTEST OR FRAILEST? COMPARING THE HEALTH OF CENTENARIANS OVER A 10-YEAR PERIOD
SURVIVAL OF THE FITTEST OR FRAILEST? COMPARING THE HEALTH OF CENTENARIANS OVER A 10-YEAR PERIOD Open
The first centenarian study in Hong Kong was conducted in 2011 and examined the multidimensional health of adults aged 95 or older. The 2011 study found that, among a population of about 3,000 centenarians, a significant proportion enjoyed…
View article: Barriers & Facilitators of People With Disabilities in Accepting & Adopting Autonomous Shared Mobility Services (Project A5)
Barriers & Facilitators of People With Disabilities in Accepting & Adopting Autonomous Shared Mobility Services (Project A5) Open
Enclosed you will find the data collected during our STRIDE Phase II Extension research project (A5) and a data dictionary.
View article: Barriers & Facilitators of People With Disabilities in Accepting & Adopting Autonomous Shared Mobility Services (Project A5)
Barriers & Facilitators of People With Disabilities in Accepting & Adopting Autonomous Shared Mobility Services (Project A5) Open
Enclosed you will find the data collected during our STRIDE Phase II Extension research project (A5) and a data dictionary.
View article: Transcranial direct current stimulation over the primary motor cortex improves speech production in post-stroke dysarthric speakers: A randomized pilot study
Transcranial direct current stimulation over the primary motor cortex improves speech production in post-stroke dysarthric speakers: A randomized pilot study Open
Purpose The current study investigated the therapeutic potential of transcranial direct current stimulation (tDCS) on speech intelligibility, speech-related physiological and vocal functions among post-stroke dysarthric patients. Method Ni…
View article: Level of Amyloid-β (Aβ) Binding Leading to Differential Effects on Resting State Functional Connectivity in Major Brain Networks
Level of Amyloid-β (Aβ) Binding Leading to Differential Effects on Resting State Functional Connectivity in Major Brain Networks Open
Introduction: Amyloid-β protein (Aβ) is one of the biomarkers for Alzheimer’s disease (AD). The recent application of interhemispheric functional connectivity (IFC) in resting-state fMRI has been used as a non-invasive diagnostic tool for …