Marc Ruel
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View article: Time-varying comparative effectiveness of surgical or percutaneous revascularization on patient-centred outcomes
Time-varying comparative effectiveness of surgical or percutaneous revascularization on patient-centred outcomes Open
The comparative risk of PACE after CABG versus PCI varied significantly over time. These findings provide granular data to support physicians and patients engaged in shared decision-making about revascularization strategies.
View article: MENDing Recovery: Comprehensive Perioperative Care Cuts Hospital Stay After Minimally Invasive CABG
MENDing Recovery: Comprehensive Perioperative Care Cuts Hospital Stay After Minimally Invasive CABG Open
Objective: To evaluate the impact of a novel multidisciplinary initiative, known as the Multimodal ENhanced Discharge (MEND), on length of stay (LOS) for patients undergoing minimally invasive coronary artery bypass grafting (MICS CABG). M…
View article: The Obesity Paradox in Patients Undergoing Surgical Repair of Degenerative Mitral Regurgitation
The Obesity Paradox in Patients Undergoing Surgical Repair of Degenerative Mitral Regurgitation Open
Background: The obesity paradox describes the beneficial influence of an elevated body mass index on health outcomes. Currently, few studies have evaluated BMI and its impact on survival following surgical repair of degenerative mitral reg…
View article: Miniaturized Devices for On‐the‐Spot Generation of Small‐Diameter Vascular Grafts
Miniaturized Devices for On‐the‐Spot Generation of Small‐Diameter Vascular Grafts Open
With over 17 million annual fatalities, cardiovascular disease remains the leading cause of death worldwide, with myocardial infarction (MI) leading the mortality burden. MI is characterized by reduced blood flow in one or more coronary ar…
View article: Urgent Cardiac Surgery for Endocarditis and Intracranial Hemorrhage Causing Midline Cerebral Shift
Urgent Cardiac Surgery for Endocarditis and Intracranial Hemorrhage Causing Midline Cerebral Shift Open
Intracranial hemorrhage is a rare and severe complication of infective endocarditis. Current treatment guidelines recommend 4 weeks between intracranial hemorrhage onset and cardiac surgery. However, some exceptions warrant earlier surgica…
View article: Midterm survival, clinical, and hemodynamic outcomes of a novel mechanical mitral valve prosthesis
Midterm survival, clinical, and hemodynamic outcomes of a novel mechanical mitral valve prosthesis Open
The On-X mechanical mitral valve demonstrated favorable survival, stable hemodynamics, and enhanced quality of life up to 5 years postimplantation. Derived from high-quality, rigorous randomized trial data, these findings can guide decisio…
View article: Surgical Aortic Valve Replacement For Bicuspid And Tricuspid Valve Disease: 7-Year Outcomes In >1100 Patients
Surgical Aortic Valve Replacement For Bicuspid And Tricuspid Valve Disease: 7-Year Outcomes In >1100 Patients Open
Introduction: Bicuspid aortic valve affects 0.5-2% of the population in developed countries. Given uncertainties about the best aortic valve replacement (AVR) option in this often younger, low-risk, population, it is important to understan…
View article: Longitudinal Outcomes Following Mitral Valve Repair for Infective Endocarditis
Longitudinal Outcomes Following Mitral Valve Repair for Infective Endocarditis Open
Mitral valve repair is the ideal approach in managing mitral valve infective endocarditis for patients requiring surgery. However, viable repair is influenced by the extent of valve destruction and there can be technical challenges in reco…
View article: Coronary artery bypass grafting in acute coronary syndromes: modern indications and approaches
Coronary artery bypass grafting in acute coronary syndromes: modern indications and approaches Open
Purpose of review Acute coronary syndromes (ACS) are a leading cause of morbidity and mortality worldwide, with approximately 1.2 million hospitalizations annually in the U.S. This review aims to explore the contemporary evidence regarding…
View article: Canadian Cardiovascular Society Clinical Practice Update on Contemporary Management of the Patient With Hypertrophic Cardiomyopathy
Canadian Cardiovascular Society Clinical Practice Update on Contemporary Management of the Patient With Hypertrophic Cardiomyopathy Open
Numerous guidelines on the diagnosis and management of hypertrophic cardiomyopathy (HCM) have been published, by learned societies, over the past decade. Although helpful they are often long and less adapted to nonexperts. This writing pan…
View article: Association between overweight and obesity with coronary artery bypass graft failure: an individual patient data analysis of clinical trials
Association between overweight and obesity with coronary artery bypass graft failure: an individual patient data analysis of clinical trials Open
OBJECTIVES The association between obesity and graft failure after coronary artery bypass grafting has not been previously investigated. METHODS We pooled individual patient data from randomized clinical trials with systematic postoperativ…
View article: The ROMA trial: 7 years of trial activities and the development of the ROMA trial network
The ROMA trial: 7 years of trial activities and the development of the ROMA trial network Open
Journal Article The ROMA trial: 7 years of trial activities and the development of the ROMA trial network Get access Mario Gaudino, Mario Gaudino Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA Corresponding…
View article: Multipurpose On‐the‐Spot Peptide‐Based Hydrogels for Skin, Cornea, and Heart Repair
Multipurpose On‐the‐Spot Peptide‐Based Hydrogels for Skin, Cornea, and Heart Repair Open
Bioinspired synthetic materials can be designed as reliable, cost‐effective, and fully controlled alternatives to natural biomaterials for treating damaged tissues and organs. However, several hurdles need to be overcome for clinical trans…
View article: Biomaterials for direct cardiac repair—A rapid scoping review 2012–2022
Biomaterials for direct cardiac repair—A rapid scoping review 2012–2022 Open
A plethora of biomaterials for heart repair are being tested worldwide for potential clinical application. These therapeutics aim to enhance the quality of life of patients with heart disease using various methods to improve cardiac functi…
View article: One-month DAPT with ticagrelor and aspirin for patients undergoing coronary artery bypass grafting: rationale and design of the randomised, multicentre, double-blind, placebo-controlled ODIN trial
One-month DAPT with ticagrelor and aspirin for patients undergoing coronary artery bypass grafting: rationale and design of the randomised, multicentre, double-blind, placebo-controlled ODIN trial Open
The optimal antiplatelet strategy after coronary artery bypass graft (CABG) surgery in patients with chronic coronary syndromes (CCS) is unclear. Adding the P2Y12 inhibitor, ticagrelor, to low-dose aspirin for 1 year is associated with a r…
View article: Early and long-term outcomes of less invasive approaches to coronary artery bypass surgery
Early and long-term outcomes of less invasive approaches to coronary artery bypass surgery Open
This review outlines the development of less invasive treatments for coronary artery disease, focusing primarily on minimally invasive coronary artery bypass grafting (MICS CABG). We compare conventional coronary artery bypass grafting (CA…
View article: BEaTS-β: an open-source electromechanical bioreactor for simulating human cardiac disease conditions
BEaTS-β: an open-source electromechanical bioreactor for simulating human cardiac disease conditions Open
Heart disease remains the leading cause of worldwide mortality. Although the last decades have broadened our understanding of the biology behind the pathologies of heart disease, ex vivo systems capable of mimicking disease progression and…