Jill M. Brown
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View article: Genicular Artery Embolization: A Technical Review of Anatomy, Pathophysiology, Current Experiences, and Future Directions
Genicular Artery Embolization: A Technical Review of Anatomy, Pathophysiology, Current Experiences, and Future Directions Open
Genicular artery embolization (GAE) is an emerging minimally invasive procedure for managing knee osteoarthritis (OA), a condition affecting 365 million individuals globally. Initially developed to treat hemarthrosis, GAE selectively embol…
View article: Genicular Artery Embolization: A Technical Review of Anatomy, Pathophysiology, Current Experiences and Future Directions
Genicular Artery Embolization: A Technical Review of Anatomy, Pathophysiology, Current Experiences and Future Directions Open
Genicular artery embolization (GAE) is an emerging minimally invasive procedure for managing knee osteoarthritis (OA), a condition affecting 365 million individuals globally. Initially developed to treat hemarthrosis, GAE selectively embol…
View article: On-microscope staging of live cells reveals changes in the dynamics of transcriptional bursting during differentiation
On-microscope staging of live cells reveals changes in the dynamics of transcriptional bursting during differentiation Open
Determining the mechanisms by which genes are switched on and off during development and differentiation is a key aim of current biomedical research. Gene transcription has been widely observed to occur in a discontinuous fashion, with sho…
View article: Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus
Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus Open
The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) disease (COVID-19) pandemic has caused millions of deaths worldwide. Genome-wide association studies identified the 3p21.31 region as conferring a twofold increased risk of r…
View article: Examination of wheat kernels for the presence of Fusarium damage and mycotoxins using near-infrared hyperspectral imaging
Examination of wheat kernels for the presence of Fusarium damage and mycotoxins using near-infrared hyperspectral imaging Open
The agriculture industry experiences severe economic losses each year due to infection of cereal crops with Fusarium, often leading to contamination with the secondary metabolite mycotoxin Deoxynivalenol (DON). Timely detection of Fusarium…
View article: Brown Nat Protocols Fig 2a
Brown Nat Protocols Fig 2a Open
Figure 2 | Comparison of hybridization strategies. a, Hybridization efficiencies plotted as the percentage of signal scored (mean with SD) in C127 cells for probes pEx and pCx34 (red and green respectively). As a lack of hybridization sign…
View article: Recapitulation of erythropoiesis in congenital dyserythropoietic anemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalities
Recapitulation of erythropoiesis in congenital dyserythropoietic anemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalities Open
The investigation of inherited disorders of erythropoiesis has elucidated many of the principles underlying the production of normal red blood cells and how this is perturbed in human disease. Congenital dyserythropoietic anemia type 1 (CD…
View article: Chromatin arranges in chains of mesoscale domains with nanoscale functional topography independent of cohesin
Chromatin arranges in chains of mesoscale domains with nanoscale functional topography independent of cohesin Open
Advanced FIB-SEM and 3D-SIM imaging uncover cohesin-independent chromatin arrangement into structural and functional modules.
View article: Fluorescence Microscopy Data for Cellular Detection using Object Detection Networks.
Fluorescence Microscopy Data for Cellular Detection using Object Detection Networks. Open
This data accompanies work from the paper entitled: Object Detection Networks and Augmented Reality for Cellular Detection in Fluorescence Microscopy Acquisition and Analysis. Waithe D1*,2,, Brown JM3, Reglinski K4,6,7, Diez-Sevilla I5, R…
View article: Fluorescence Microscopy Data for Cellular Detection using Object Detection Networks.
Fluorescence Microscopy Data for Cellular Detection using Object Detection Networks. Open
This data accompanies work from the paper entitled: Object Detection Networks and Augmented Reality for Cellular Detection in Fluorescence Microscopy Acquisition and Analysis. Waithe D1*,2,, Brown JM3, Reglinski K4,6,7, Diez-Sevilla I5, R…
View article: Object detection networks and augmented reality for cellular detection in fluorescence microscopy
Object detection networks and augmented reality for cellular detection in fluorescence microscopy Open
Object detection networks are high-performance algorithms famously applied to the task of identifying and localizing objects in photography images. We demonstrate their application for the classification and localization of cells in fluore…
View article: Genetic and functional insights into CDA-I prevalence and pathogenesis
Genetic and functional insights into CDA-I prevalence and pathogenesis Open
Background Congenital dyserythropoietic anaemia type I (CDA-I) is a hereditary anaemia caused by biallelic mutations in the widely expressed genes CDAN1 and C15orf41 . Little is understood about either protein and it is unclear in which ce…
View article: ATR-16 syndrome: mechanisms linking monosomy to phenotype
ATR-16 syndrome: mechanisms linking monosomy to phenotype Open
Background Deletions removing 100s–1000s kb of DNA, and variable numbers of poorly characterised genes, are often found in patients with a wide range of developmental abnormalities. In such cases, understanding the contribution of the dele…
View article: Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells
Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells Open
How chromosome organization is related to genome function remains poorly understood. Cohesin, loop extrusion, and CCCTC-binding factor (CTCF) have been proposed to create topologically associating domains (TADs) to regulate gene expression…
View article: ATR16 Syndrome: Mechanisms Linking Monosomy to Phenotype
ATR16 Syndrome: Mechanisms Linking Monosomy to Phenotype Open
Background Sporadic deletions removing 100s-1000s kb of DNA, and variable numbers of poorly characterised genes, are often found in patients with a wide range of developmental abnormalities. In such cases, understanding the contribution of…
View article: Modelling erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I)
Modelling erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I) Open
We employ and extensively characterise an ex vivo culture system to study terminal erythroid maturation of CD34 + progenitors from the peripheral blood of normal individuals and patients with Congenital Dyserythropoietic Anaemia type 1 (CD…
View article: Fluorescence Microscopy Data for Cellular Detection using Object Detection Networks.
Fluorescence Microscopy Data for Cellular Detection using Object Detection Networks. Open
This data accompanies work from the paper entitled: Object Detection Networks and Augmented Reality for Cellular Detection in Fluorescence Microscopy Acquisition and Analysis. https://www.biorxiv.org/content/10.1101/544833v1 doi: https://…
View article: Fluorescence Microscopy Data for Cellular Detection using Object Detection Networks.
Fluorescence Microscopy Data for Cellular Detection using Object Detection Networks. Open
This data accompanies work from the paper entitled: Object Detection Networks and Augmented Reality for Cellular Detection in Fluorescence Microscopy Acquisition and Analysis. https://www.biorxiv.org/content/10.1101/544833v1 doi: https://…
View article: Fluorescence Microscopy Data for Cellular Detection using Object Detection Networks.
Fluorescence Microscopy Data for Cellular Detection using Object Detection Networks. Open
This data accompanies work from the paper entitled: Object Detection Networks and Augmented Reality for Cellular Detection in Fluorescence Microscopy Acquisition and Analysis. Further details of these datasets can be found in the methods s…
View article: Robust CRISPR/Cas9 Genome Editing of the HUDEP-2 Erythroid Precursor Line Using Plasmids and Single-Stranded Oligonucleotide Donors
Robust CRISPR/Cas9 Genome Editing of the HUDEP-2 Erythroid Precursor Line Using Plasmids and Single-Stranded Oligonucleotide Donors Open
The study of cellular processes and gene regulation in terminal erythroid development has been greatly facilitated by the generation of an immortalised erythroid cell line derived from Human Umbilical Derived Erythroid Precursors, termed H…
View article: Single-cell chromatin interactions reveal regulatory hubs in dynamic compartmentalized domains
Single-cell chromatin interactions reveal regulatory hubs in dynamic compartmentalized domains Open
The promoters of mammalian genes are commonly regulated by multiple distal enhancers, which physically interact within discrete chromatin domains. How such domains form and how the regulatory elements within them interact within single cel…
View article: A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions
A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions Open
A variety of self-interacting domains, defined at different levels of resolution, have been described in mammalian genomes. These include Chromatin Compartments (A and B) 1 , Topologically Associated Domains (TADs) 2,3 , contact domains 4,…