Joe Sexton
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View article: How to score the wrist joint by ultrasound: exploration of the most sensitive joint assessment during follow-up of early or established rheumatoid arthritis
How to score the wrist joint by ultrasound: exploration of the most sensitive joint assessment during follow-up of early or established rheumatoid arthritis Open
Background Wrist inflammation is common in patients with rheumatoid arthritis (RA), and thus there is room for debate on which joints to include in an ultrasound-based scoring of wrist synovitis in RA. This study aimed to identify the most…
View article: Acute drought desiccates highly used habitat and drives herbivores into irrigated croplands
Acute drought desiccates highly used habitat and drives herbivores into irrigated croplands Open
In arid and semiarid regions, extreme, extended droughts are becoming more frequent due to climate change. Drought is driving wildlife to seek out food or water resources where they are not as limited, such as in irrigated croplands. We co…
View article: Recognition of Glycine Versus Nonglycine Citrulline Motifs Dictating the <scp>HLA</scp> Class <scp>II</scp> Association of Anticitrullinated Protein Antibodies: Insights From Autoantibody Profiling of 6,900 Scandinavian Patients With Rheumatoid Arthritis
Recognition of Glycine Versus Nonglycine Citrulline Motifs Dictating the <span>HLA</span> Class <span>II</span> Association of Anticitrullinated Protein Antibodies: Insights From Autoantibody Profiling of 6,900 Scandinavian Patients With Rheumatoid Arthritis Open
Objective Rheumatoid arthritis (RA)–associated anticitrullinated protein antibodies (ACPAs) target various antigens by binding short citrulline amino acid motifs, resulting in heterogeneous ACPA profiles among patients. Here we analyzed AC…
View article: Predictors of 1-year mortality in a clinical cohort of hip fracture patients
Predictors of 1-year mortality in a clinical cohort of hip fracture patients Open
Purpose Knowledge about factors associated with mortality after hip fracture is important both for analytical and clinical purposes. This study aimed to assess patient risk factors and commonly used composite scores for prediction of 1-yea…
View article: Remission in gout is possible: 5-year follow-up in the NOR-Gout study
Remission in gout is possible: 5-year follow-up in the NOR-Gout study Open
Remission in gout after urate lowering therapy was seldom after 1 but high after 5 years and was highest for the simplified definition. Remission definitions showed concurrent validity for quality of life and structural changes.
View article: Development of machine learning models for predicting non-remission in early RA highlights the robust predictive importance of the RAID score-evidence from the ARCTIC study
Development of machine learning models for predicting non-remission in early RA highlights the robust predictive importance of the RAID score-evidence from the ARCTIC study Open
Introduction Achieving remission is a critical therapeutic goal in the management of rheumatoid arthritis (RA). Despite methotrexate being the cornerstone of early RA treatment, a significant proportion of patients fail to achieve remissio…
View article: Toward the quantification of the climate co-benefits of invasive mammal eradication on islands: a scalable framework for restoration monitoring
Toward the quantification of the climate co-benefits of invasive mammal eradication on islands: a scalable framework for restoration monitoring Open
Islands are hotspots of biological and cultural diversity that face growing threats from invasive species and climate change. Invasive mammal eradication on islands is a proven conservation intervention that prevents biodiversity loss and …
View article: Non-adherence to urate lowering therapy in gout after 5 years is related to poor outcomes: results from the NOR-Gout study
Non-adherence to urate lowering therapy in gout after 5 years is related to poor outcomes: results from the NOR-Gout study Open
Objectives Patients with gout need to adhere to medication over time to achieve good outcomes. We assessed self-reported adherence to medication with urate lowering therapy (ULT) 5 years after a treat-to-target intervention and studied how…
View article: Interstitial Lung Disease in Patients With Rheumatoid Arthritis or Psoriatic Arthritis Initiating Biologics and Controls: Data From 5 Nordic Registries
Interstitial Lung Disease in Patients With Rheumatoid Arthritis or Psoriatic Arthritis Initiating Biologics and Controls: Data From 5 Nordic Registries Open
Objective Interstitial lung disease (ILD) is one of the most common pulmonary manifestations of rheumatoid arthritis (RA), but its prevalence has not been investigated in psoriatic arthritis (PsA). The role of methotrexate (MTX) in ILD dev…
View article: Agreement between patient-reported flares and clinically significant flare status in patients with rheumatoid arthritis in sustained remission: data from the ARCTIC REWIND trials
Agreement between patient-reported flares and clinically significant flare status in patients with rheumatoid arthritis in sustained remission: data from the ARCTIC REWIND trials Open
Objectives To explore the agreement between patient-reported flare status and clinically significant flare status in patients with rheumatoid arthritis (RA) in sustained remission. Method Patients with RA in remission for ≥12 months on sta…
View article: Biological material for biomarker research in spondyloarthritis: mapping the availability in European rheumatology registries
Biological material for biomarker research in spondyloarthritis: mapping the availability in European rheumatology registries Open
Dear Editor, Psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) are chronic inflammatory diseases involving peripheral and axial joints and entheses. They are characterized by chronic inflammation and progressive structural dama…
View article: Improving Consistency and Accuracy: A Novel C. auris Colonization Screening Strategy Using a Nares + Hands Composite Swab
Improving Consistency and Accuracy: A Novel C. auris Colonization Screening Strategy Using a Nares + Hands Composite Swab Open
Background: Candida auris is often identified in healthcare settings through bilateral composite of axilla/groin skin swabs screening. Re-screening the same patient has demonstrated inconsistent results over time, complicating the understa…
View article: Beliefs about medicines in gout patients: results from the NOR-Gout 2-year study
Beliefs about medicines in gout patients: results from the NOR-Gout 2-year study Open
ACTRN12618001372279.
View article: Calprotectin, a sensitive marker of inflammation, is robustly assessed in plasma from patients with early or established rheumatoid arthritis by use of different laboratory methods
Calprotectin, a sensitive marker of inflammation, is robustly assessed in plasma from patients with early or established rheumatoid arthritis by use of different laboratory methods Open
Calprotectin (S100A8/S100A9, MRP8/MRP14) is a major leukocyte protein found to be more sensitive than C-Reactive Protein (CRP) and Erythrocyte Sedimentation Rate (ESR) as a marker of inflammation in patients with rheumatoid arthritis (RA).…
View article: Patterns of regional site index across a North American boreal forest gradient
Patterns of regional site index across a North American boreal forest gradient Open
Forest structure—the height, cover, vertical complexity, and spatial patterns of trees—is a key indicator of productivity variation across forested extents. During the 2017 and 2019 growing seasons, NASA’s Arctic-Boreal Vulnerability Exper…
View article: Investigation of the first cluster of <i>Candida auris</i> cases among pediatric patients in the United States―Nevada, May 2022
Investigation of the first cluster of <i>Candida auris</i> cases among pediatric patients in the United States―Nevada, May 2022 Open
Background: Candida auris is a frequently drug-resistant yeast that can cause invasive disease and is easily transmitted in healthcare settings. Pediatric cases are rare in the United States, with <10 reported before 2022. In August 2021, …
View article: POS0345 ADALIMUMAB SERUM DRUG LEVELS AND ANTI-DRUG ANTIBODIES: ASSOCIATION TO DISEASE ACTIVITY AND DRUG SURVIVAL IN INFLAMMATORY ARTHRITIS PATIENTS
POS0345 ADALIMUMAB SERUM DRUG LEVELS AND ANTI-DRUG ANTIBODIES: ASSOCIATION TO DISEASE ACTIVITY AND DRUG SURVIVAL IN INFLAMMATORY ARTHRITIS PATIENTS Open
Background Lack of response to TNF-inhibitors (TNFi) can be caused by subtherapeutic drug levels and anti-drug antibodies (ADAb). Therapeutic-drug-monitoring (TDM) can help clinicians tailor treatment and may improve effectiveness, safety …
View article: POS0252 DIFFERENCES IN SERUM DRUG LEVELS AND ANTI-DRUG ANTIBODIES IN PATIENTS WITH INFLAMMATORY ARTHRITIS TREATED WITH ORIGINATOR VS BIOSIMILAR ADALIMUMAB
POS0252 DIFFERENCES IN SERUM DRUG LEVELS AND ANTI-DRUG ANTIBODIES IN PATIENTS WITH INFLAMMATORY ARTHRITIS TREATED WITH ORIGINATOR VS BIOSIMILAR ADALIMUMAB Open
Background Serum drug levels and anti-drug antibodies (ADAb) impact the therapeutic effectiveness of most TNF-inhibitors. Possible differences in immunogenicity profile and pharmacokinetics across biosimilar and originator TNFi are still t…