Joseph P. Connor
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View article: Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle
Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle Open
All coronaviruses (CoVs) encode a conserved macrodomain, termed Mac1, in non-structural protein 3 (nsp3) that binds and hydrolyzes ADP-ribose covalently attached to proteins. Mac1 is a key virulence factor that counters antiviral ADP-ribos…
View article: Expanded use of liquid plasma in non‐emergency transfusions: A single academic institution experience
Expanded use of liquid plasma in non‐emergency transfusions: A single academic institution experience Open
Background Liquid plasma (LP) is isolated from whole blood donations, never frozen, and can be immediately transfused. Its primary indication is initial treatment of patients undergoing massive transfusion. To minimize wastage of this reso…
View article: Data-driven education improves patient blood management: A pilot study
Data-driven education improves patient blood management: A pilot study Open
Introduction: We sought to increase the use of a restrictive transfusion protocol through clinician education and a standard approach to Patient Blood Management (PBM) in our gynecologic oncology service. Optimal PBM requires the consisten…
View article: Validation framework for the use of AI in healthcare: overview of the new British standard BS30440
Validation framework for the use of AI in healthcare: overview of the new British standard BS30440 Open
The British standard 'BS30440: Validation Framework for the Use of AI in Healthcare' will be published in the second quarter of 2023.[1][1] It details the evidence required by technology developers to assess and validate products using art…
View article: Red Blood Cell Exchange for a Patient with Dapsone-Induced Methemoglobinemia, Severe Methylene Blue Allergy, and Refractoriness to Intravenous Vitamin C Therapy
Red Blood Cell Exchange for a Patient with Dapsone-Induced Methemoglobinemia, Severe Methylene Blue Allergy, and Refractoriness to Intravenous Vitamin C Therapy Open
The most common cause of acquired methemoglobinemia is dapsone toxicity.There are no definitive guidelines for the management of treatment-refractory methemoglobinemia or when methylene blue therapy is contraindicated.We present a case of …
View article: Data from Fundamental Differences in Cell Cycle Deregulation in Human Papillomavirus–Positive and Human Papillomavirus–Negative Head/Neck and Cervical Cancers
Data from Fundamental Differences in Cell Cycle Deregulation in Human Papillomavirus–Positive and Human Papillomavirus–Negative Head/Neck and Cervical Cancers Open
Human papillomaviruses (HPV) are associated with nearly all cervical cancers, 20% to 30% of head and neck cancers (HNC), and other cancers. Because HNCs also arise in HPV-negative patients, this type of cancer provides unique opportunities…
View article: Supplementary Methods, Figures 1-6 from Fundamental Differences in Cell Cycle Deregulation in Human Papillomavirus–Positive and Human Papillomavirus–Negative Head/Neck and Cervical Cancers
Supplementary Methods, Figures 1-6 from Fundamental Differences in Cell Cycle Deregulation in Human Papillomavirus–Positive and Human Papillomavirus–Negative Head/Neck and Cervical Cancers Open
Supplementary Methods, Figures 1-6 from Fundamental Differences in Cell Cycle Deregulation in Human Papillomavirus–Positive and Human Papillomavirus–Negative Head/Neck and Cervical Cancers
View article: Data from Fundamental Differences in Cell Cycle Deregulation in Human Papillomavirus–Positive and Human Papillomavirus–Negative Head/Neck and Cervical Cancers
Data from Fundamental Differences in Cell Cycle Deregulation in Human Papillomavirus–Positive and Human Papillomavirus–Negative Head/Neck and Cervical Cancers Open
Human papillomaviruses (HPV) are associated with nearly all cervical cancers, 20% to 30% of head and neck cancers (HNC), and other cancers. Because HNCs also arise in HPV-negative patients, this type of cancer provides unique opportunities…
View article: Supplementary Methods, Figures 1-6 from Fundamental Differences in Cell Cycle Deregulation in Human Papillomavirus–Positive and Human Papillomavirus–Negative Head/Neck and Cervical Cancers
Supplementary Methods, Figures 1-6 from Fundamental Differences in Cell Cycle Deregulation in Human Papillomavirus–Positive and Human Papillomavirus–Negative Head/Neck and Cervical Cancers Open
Supplementary Methods, Figures 1-6 from Fundamental Differences in Cell Cycle Deregulation in Human Papillomavirus–Positive and Human Papillomavirus–Negative Head/Neck and Cervical Cancers
View article: Pre-operative anemia and peri-operative transfusion are associated with poor oncologic outcomes in cancers of the esophagus: potential impact of patient blood management on cancer outcomes
Pre-operative anemia and peri-operative transfusion are associated with poor oncologic outcomes in cancers of the esophagus: potential impact of patient blood management on cancer outcomes Open
Background Both Red Blood Cell (RBC) transfusion and anemia are thought to negatively impact cancer survival. These effects have been reported with mixed findings in cancer of the esophagus. The potential impact of the application of restr…
View article: UCL MotionInput: Touchless computing interactions in clinical training, radiology and operating theatres
UCL MotionInput: Touchless computing interactions in clinical training, radiology and operating theatres Open
View article: Blood products and liver transplantation: A strategy to balance optimal preparation with effective blood stewardship
Blood products and liver transplantation: A strategy to balance optimal preparation with effective blood stewardship Open
Background Unanticipated transfusion requirements during liver transplantation can delay lifesaving intraoperative resuscitation and strain blood bank resources. Risk‐stratified preoperative blood preparation can mitigate these deleterious…
View article: Efficacy and safety of a restrictive blood transfusion protocol in gynecologic surgical patients
Efficacy and safety of a restrictive blood transfusion protocol in gynecologic surgical patients Open
View article: Anti-SARS-CoV-2 IgG and IgA antibodies in COVID-19 convalescent plasma do not enhance viral infection
Anti-SARS-CoV-2 IgG and IgA antibodies in COVID-19 convalescent plasma do not enhance viral infection Open
The novel coronavirus, SARS-CoV-2 that causes COVID-19 has resulted in the death of nearly 4 million people within the last 18 months. While preventive vaccination, and monoclonal antibody therapies have been rapidly developed and deployed…
View article: Author Index
Author Index Open
View article: Efficacy and safety of institution-wide restrictive blood transfusion protocol in gynecologic surgical patients
Efficacy and safety of institution-wide restrictive blood transfusion protocol in gynecologic surgical patients Open
View article: Anti-SARS-CoV-2 IgG and IgA antibodies in COVID-19 convalescent plasma do not enhance viral infection
Anti-SARS-CoV-2 IgG and IgA antibodies in COVID-19 convalescent plasma do not enhance viral infection Open
The novel coronavirus, SARS-CoV-2 that causes COVID-19 has resulted in the death of nearly 4 million people within the last 18 months. While preventive vaccination, and monoclonal antibody therapies have been rapidly developed and deployed…
View article: Anti-SARS-CoV-2 IgG and IgA antibodies in COVID-19 convalescent plasma do not facilitate antibody-dependent enhance of viral infection
Anti-SARS-CoV-2 IgG and IgA antibodies in COVID-19 convalescent plasma do not facilitate antibody-dependent enhance of viral infection Open
The novel coronavirus SARS-CoV2, which causes COVID-19, has resulted in the death of nearly 4 million people within the last 18 months. While preventive vaccination and monoclonal antibody therapies have been rapidly developed and deployed…
View article: Predicting the efficacy of COVID-19 convalescent plasma donor units with the Lumit Dx anti-receptor binding domain assay
Predicting the efficacy of COVID-19 convalescent plasma donor units with the Lumit Dx anti-receptor binding domain assay Open
Background The novel coronavirus SARS-CoV2 that causes COVID-19 has resulted in the death of more than 2.5 million people, but no cure exists. Although passive immunization with COVID-19 convalescent plasma (CCP) provides a safe and viable…
View article: Predicting the Efficacy of COVID-19 Convalescent Plasma Donor Units with the Lumit Dx anti-Receptor Binding Domain Assay
Predicting the Efficacy of COVID-19 Convalescent Plasma Donor Units with the Lumit Dx anti-Receptor Binding Domain Assay Open
Background The novel coronavirus SARS-CoV2 that causes COVID-19 has resulted in the death of more than 2.5 million people, but no cure exists. Although passive immunization with COVID-19 convalescent plasma (CCP) provides a safe and viable…
View article: Donor Anti-Spike Immunity is Related to Recipient Recovery and Can Predict the Efficacy of Convalescent Plasma Units
Donor Anti-Spike Immunity is Related to Recipient Recovery and Can Predict the Efficacy of Convalescent Plasma Units Open
Background The novel coronavirus, SARS-CoV2 that causes COVID-19 has resulted in the death of more than 2.31 million people within the last year and yet no cure exists. Whereas passive immunization with COVID-19 convalescent plasma (CCP) p…
View article: Response to Convalescent Plasma is not Influenced by Patient Blood Type
Response to Convalescent Plasma is not Influenced by Patient Blood Type Open
Background: SARS-CoV2 virus is associated with 580,000 deaths and 32.5 million cases of COVID-19 infection in the United States. Data exist suggesting a correlation between blood type and disease acquisition and severity. No such data exis…
View article: Hospitalized COVID-19 patients treated with convalescent plasma in a mid-size city in the Midwest
Hospitalized COVID-19 patients treated with convalescent plasma in a mid-size city in the Midwest Open
View article: Unusual Cardiac Presentation of COVID-19 and Use of Convalescent Plasma
Unusual Cardiac Presentation of COVID-19 and Use of Convalescent Plasma Open
COVID-19 infection caused by the SARS-CoV-2 virus has been associated with cardiac abnormalities, including conduction abnormalities. Convalescent plasma is emerging as a potentially safe and effective treatment option for patients severel…
View article: Hospitalized COVID-19 Patients treated with Convalescent Plasma in a Mid-size City in the Midwest
Hospitalized COVID-19 Patients treated with Convalescent Plasma in a Mid-size City in the Midwest Open
BackgroundSARS-CoV-2 and its associated disease, COVID-19, has infected over seven million people world-wide, including two million people in the United States. While many people recover from the virus uneventfully, a subset of patients wi…
View article: Hospitalized COVID-19 Patients Treated With Convalescent Plasma in a Mid-size City in The Mid West
Hospitalized COVID-19 Patients Treated With Convalescent Plasma in a Mid-size City in The Mid West Open
View article: Hospitalized COVID-19 Patients treated with Convalescent Plasma in a Mid-size City in the Midwest
Hospitalized COVID-19 Patients treated with Convalescent Plasma in a Mid-size City in the Midwest Open
View article: Hospitalized COVID-19 Patients treated with Convalescent Plasma in a Mid-size City in the Midwest
Hospitalized COVID-19 Patients treated with Convalescent Plasma in a Mid-size City in the Midwest Open
Background SARS-CoV-2 and its associated disease, COVID-19, has infected over seven million people world-wide, including two million people in the United States. While many people recover from the virus uneventfully, a subset of patients w…
View article: Persistent viral <scp>RNA</scp> shedding after <scp>COVID</scp> ‐19 symptom resolution in older convalescent plasma donors
Persistent viral <span>RNA</span> shedding after <span>COVID</span> ‐19 symptom resolution in older convalescent plasma donors Open
Introduction The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is responsible for a worldwide pandemic. While the medical community understands the mode of viral transmission, less is known about how long…
View article: Prolonged viral RNA shedding after COVID-19 symptom resolution in older convalescent plasma donors
Prolonged viral RNA shedding after COVID-19 symptom resolution in older convalescent plasma donors Open
Importance The novel coronavirus, SARS-CoV-2, is responsible for a world-wide pandemic. While the medical community understands the mode of viral transmission, less is known about how long viral shedding occurs once viral symptoms have res…